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Recent advances in nuclear actin research Open
Actin was first observed in the nucleus more than sixty years ago but research on nuclear actin did not receive significant attention for the next forty years. It only started to accelerate around the year 2000, when the first convincing e…
View article: Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus
Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus Open
The members of the evolutionary conserved actin-binding Ezrin, Radixin and Moesin (ERM) protein family are involved in numerous key cellular processes in the cytoplasm. In the last decades, ERM proteins, like actin and other cytoskeletal c…
A bipartite NLS motif mediates the nuclear import of Drosophila moesin Open
The ERM protein family, which consists of three closely related proteins in vertebrates, ezrin, radixin, and moesin (ERM), is an ancient and important group of cytoplasmic actin-binding and organizing proteins. With their FERM domain, ERMs…
FERM domain–containing proteins are active components of the cell nucleus Open
The FERM domain is a conserved and widespread protein module that appeared in the common ancestor of amoebae, fungi, and animals, and is therefore now found in a wide variety of species. The primary function of the FERM domain is localizin…
Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila Open
Actin, as an ancient and fundamental protein, participates in various cytoplasmic as well as nuclear functions in eukaryotic cells. Based on its manifold tasks in the nucleus, it is a reasonable assumption that the nuclear presence of acti…
The nuclear activity of the actin‐binding Moesin protein is necessary for gene expression in <i>Drosophila</i> Open
Ezrin–Radixin–Moesin (ERM) proteins play an essential role in the cytoplasm by cross‐linking actin filaments with plasma membrane proteins. Research has identified the nuclear localization of ERMs, as well as the involvement of a single Dr…