Peter Bownes
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View article: Conformal 3D computed tomography planned endoluminal brachytherapy for the local control of esophageal cancer
Conformal 3D computed tomography planned endoluminal brachytherapy for the local control of esophageal cancer Open
3D conformal planned ELBT is safe and tolerable. Most patients exhibit an early and sustained stabilization or improvement in their swallow function and greater survival is seen with higher brachytherapy doses. Further research is required…
View article: Reirradiation Options for Previously Irradiated Prostate cancer (RO-PIP): Feasibility study investigating toxicity outcomes following reirradiation with stereotactic body radiotherapy (SBRT) versus high-dose-rate brachytherapy (HDR-BT)
Reirradiation Options for Previously Irradiated Prostate cancer (RO-PIP): Feasibility study investigating toxicity outcomes following reirradiation with stereotactic body radiotherapy (SBRT) versus high-dose-rate brachytherapy (HDR-BT) Open
Introduction Radiotherapy is the most common curative treatment for non-metastatic prostate cancer; however, up to 13% of patients will develop local recurrence within 10 years. Patients can undergo further and potentially curative treatme…
View article: UK audit of target volume and organ at risk delineation and dose optimisation for cervix radiotherapy treatments
UK audit of target volume and organ at risk delineation and dose optimisation for cervix radiotherapy treatments Open
Objective: Assessment of the extent of variation in delineations and dose optimisation performed at multiple UK centres as a result of interobserver variation and protocol differences. Methods: CT/MR images of 2 cervical cancer patients pr…
View article: Ten-year longitudinal health-related quality of life following iodine-125 brachytherapy monotherapy for localized prostate cancer
Ten-year longitudinal health-related quality of life following iodine-125 brachytherapy monotherapy for localized prostate cancer Open
Clinically mild changes in urinary, bowel, and sexual QoL are found 10 years after 125I monotherapy. The impairment in sexual function persists from treatment, but urinary and bowel symptoms are new at 10 years.
View article: A high-precision, geometric and registration accuracy full-system test method for adaptive SRS, demonstrated on Gamma Knife® Icon™.
A high-precision, geometric and registration accuracy full-system test method for adaptive SRS, demonstrated on Gamma Knife® Icon™. Open
A novel full-system test (FST) phantom and method have been developed to demonstrate and quality assure the geometric accuracy of image co-registration and overall shot delivery in the context of SRS using Gamma Knife® Icon™. The method us…
View article: Intra-fraction motion gating during frameless Gamma Knife<sup>®</sup> Icon™ therapy: The relationship between cone beam CT assessed intracranial anatomy displacement and infrared-tracked nose marker displacement.
Intra-fraction motion gating during frameless Gamma Knife<sup>®</sup> Icon™ therapy: The relationship between cone beam CT assessed intracranial anatomy displacement and infrared-tracked nose marker displacement. Open
Intracranial targets typically displace by a magnitude around half that of the nose. Novel analysis to determine the spatial variation of target-to-nose displacement ratio suggests, for our 41 targets, HDMM threshold could have been increa…
View article: A standardised method for use of the Leksell GammaPlan Inverse Planning module for metastases.
A standardised method for use of the Leksell GammaPlan Inverse Planning module for metastases. Open
The standardised method for using the optimisation module has potential for shortening treatment times and planning times.
View article: A comparison of the convolution and TMR10 treatment planning algorithms for Gamma Knife<sup>®</sup> radiosurgery.
A comparison of the convolution and TMR10 treatment planning algorithms for Gamma Knife<sup>®</sup> radiosurgery. Open
Convolution provides superior accuracy versus TMR10 in heterogeneous conditions. Implementing convolution would result in increased target doses therefore its implementation may require a revaluation of prescription doses.
View article: Importance of dynamic contrast enhanced magnetic resonance imaging for targeting biopsy and salvage treatments after prostate cancer recurrence
Importance of dynamic contrast enhanced magnetic resonance imaging for targeting biopsy and salvage treatments after prostate cancer recurrence Open
In prostate cancer patients previously treated with I-125 permanent seed implants, DCE-MRI is superior to T2W and DWI in defining areas of recurrence, and should be used to target biopsy and for treatment planning of focal salvage therapie…
View article: Quantifying the effects of positional uncertainties and estimating margins for Gamma-Knife<sup>®</sup> fractionated radiosurgery of large brain metastases.
Quantifying the effects of positional uncertainties and estimating margins for Gamma-Knife<sup>®</sup> fractionated radiosurgery of large brain metastases. Open
For fractionated GK treatment of large brain metastases prescribing to the 50% isodose minimizes the effect of random error.For conventional single fraction SRS, the effect of positional uncertainty is always systematic. However, for fract…
View article: Quantifying the trigger level of the vacuum surveillance system of the Gamma-Knife eXtend™ positioning system and evaluating the potential impact on dose delivery.
Quantifying the trigger level of the vacuum surveillance system of the Gamma-Knife eXtend™ positioning system and evaluating the potential impact on dose delivery. Open
The trigger level is sensitive and reproducible. A sudden movement by the patient, such as an attempt to get out or correct an uncomfortable position would interrupt irradiation immediately. The dominant effect for a displacement is due to…