Peter Briza
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View article: Engineering Chimeric Hypoallergens for Safer and More Effective House Dust Mite Allergy Vaccines
Engineering Chimeric Hypoallergens for Safer and More Effective House Dust Mite Allergy Vaccines Open
Summary Box Chimeric hypoallergens of Der p 1 and Blo t 1 (QBD2/QBD4) reduce IgE reactivity and airway inflammation in mice. QBD4 promotes Th1/regulatory responses, suppressing mucus and eosinophilia more effectively than QBD2.
View article: A Treatment-Resistant Severe Asthma Phenotype with Dysregulated Hippo Pathway as Shown by Sputum Transcriptomics and Proteomics
A Treatment-Resistant Severe Asthma Phenotype with Dysregulated Hippo Pathway as Shown by Sputum Transcriptomics and Proteomics Open
Severe asthma is a heterogeneous condition often resistant to conventional corticosteroid therapy, necessitating the identification of novel biomarkers and therapeutic targets. This study investigates immunological, transcriptional, and pr…
View article: Evaluation of Inhibitory Activity of Novel Monoclonal Antibodies Against Cat Allergen Fel d 7 and Their Application to Analyse Allergen Extracts
Evaluation of Inhibitory Activity of Novel Monoclonal Antibodies Against Cat Allergen Fel d 7 and Their Application to Analyse Allergen Extracts Open
Current characterisation of cat dander/hair extracts used for allergy diagnosis or allergen‐specific immunotherapy is mainly standardised towards the major allergen Fel d 1, while other allergens such as the lipocalin Fel d 7 are insuffici…
View article: A Treatment-Resistant Severe Asthma Phenotype with Dysregulated Hippo Pathway as Shown by Sputum Transcriptomics and Proteomics
A Treatment-Resistant Severe Asthma Phenotype with Dysregulated Hippo Pathway as Shown by Sputum Transcriptomics and Proteomics Open
Severe asthma is a heterogeneous condition often resistant to conventional corticosteroid therapy, necessitating the identification of novel biomarkers and therapeutic targets. This study investigates immunological, transcriptional, and pr…
View article: Deceptive <i>Ceropegia sandersonii</i> uses an arabinogalactan for trapping its fly pollinators
Deceptive <i>Ceropegia sandersonii</i> uses an arabinogalactan for trapping its fly pollinators Open
Summary Many plant species have evolved surfaces that reduce insect attachment. Among such plants are deceptive trap flowers of Ceropegia . Their gliding zones consist of convex epidermal cells, each with a bristle‐like central protuberanc…
View article: Conformational and Functional Regulation of SET by Legumain Cleavage
Conformational and Functional Regulation of SET by Legumain Cleavage Open
The cysteine protease legumain typically localizes to the endolysosomal system, where it is an important player in the immune system. However, in the context of Alzheimer's disease (AD), legumain has been shown to be translocated to the cy…
View article: Conformational and Functional Regulation of SET by Legumain Cleavage
Conformational and Functional Regulation of SET by Legumain Cleavage Open
The cysteine protease legumain typically localizes to the endolysosomal system, where it is an important player in the immune system. However, in the context of Alzheimer’s disease (AD), legumain has been shown to be translocated to the cy…
View article: Exploring Inflammatory Asthma Phenotypes: Proteomic Signatures in Serum and Induced Sputum
Exploring Inflammatory Asthma Phenotypes: Proteomic Signatures in Serum and Induced Sputum Open
Asthma drug responses may differ due to inflammatory mechanisms triggered by the immune cells in the pulmonary microenvironment. Thus, asthma phenotyping based on the local inflammatory profile may aid in treatment definition and the ident…
View article: Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress
Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress Open
Protein aggregates arise naturally under normal physiological conditions, but their formation is accelerated by age or stress-induced protein misfolding. When the stressful event dissolves, these aggregates are removed by mechanisms, such …
View article: Comparison of Antibody Responses against Two Molecules from Ascaris lumbricoides: The Allergen Asc l 5 and the Immunomodulatory Protein Al-CPI
Comparison of Antibody Responses against Two Molecules from Ascaris lumbricoides: The Allergen Asc l 5 and the Immunomodulatory Protein Al-CPI Open
Immunity to Ascaris lumbricoides influences the pathogenesis of allergic diseases. Antibody responses to its proteins have been found to be associated with asthma presentation; however, helminth products that induce immunosuppression have …
View article: Phytocystatin 6 is a context‐dependent, tight‐binding inhibitor of <i>Arabidopsis thaliana</i> legumain isoform β
Phytocystatin 6 is a context‐dependent, tight‐binding inhibitor of <i>Arabidopsis thaliana</i> legumain isoform β Open
SUMMARY Plant legumains are crucial for processing seed storage proteins and are critical regulators of plant programmed cell death. Although research on legumains boosted recently, little is known about their activity regulation. In our s…
View article: Phytocystatin 6 is a context-dependent, tight-binding inhibitor of<i>Arabidopsis thaliana</i>legumain isoform β
Phytocystatin 6 is a context-dependent, tight-binding inhibitor of<i>Arabidopsis thaliana</i>legumain isoform β Open
Plant legumains are crucial for processing seed storage proteins and are critical regulators of plant programmed cell death. Although research on legumains boosted recently, little is known about their activity regulation. In our study, we…
View article: Structural and functional studies of legumain–mycocypin complexes revealed a competitive, exosite-regulated mode of interaction
Structural and functional studies of legumain–mycocypin complexes revealed a competitive, exosite-regulated mode of interaction Open
Under pathophysiologic conditions such as Alzheimer's disease and cancer, the endolysosomal cysteine protease legumain was found to translocate to the cytosol, the nucleus, and the extracellular space. These noncanonical localizations dema…
View article: Eosinophilic esophagitis auxiliary diagnosis based on a peptide ligand to eosinophil cationic protein in esophageal mucus of pediatric patients
Eosinophilic esophagitis auxiliary diagnosis based on a peptide ligand to eosinophil cationic protein in esophageal mucus of pediatric patients Open
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus characterized by increased number of eosinophils. Currently, EoE diagnosis is based on endoscopic procedures for histopathological examination, eosinophils…
View article: Structural Alterations of Antigens at the Material Interface: An Early Decision Toolbox Facilitating Safe-by-Design Nanovaccine Development
Structural Alterations of Antigens at the Material Interface: An Early Decision Toolbox Facilitating Safe-by-Design Nanovaccine Development Open
Nanomaterials have found extensive interest in the development of novel vaccines, as adjuvants and/or carriers in vaccination platforms. Conjugation of protein antigens at the particle surface by non-covalent adsorption is the most widely …
View article: The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities
The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities Open
Protein modification by enzymatic breaking and forming of peptide bonds significantly expands the repertoire of genetically encoded protein sequences. The dual protease-ligase legumain exerts the two opposing activities within a single pro…
View article: Component-Resolved Diagnosis of American Cockroach (Periplaneta americana) Allergy in Patients From Different Geographical Areas
Component-Resolved Diagnosis of American Cockroach (Periplaneta americana) Allergy in Patients From Different Geographical Areas Open
Background: Manifestation of respiratory allergy to American cockroach ( Periplaneta americana ) is prominent in the subtropical and tropical areas. However, co-existing perennial indoor inhalant allergies frequently compromise clinical di…
View article: Chemical modification of ragweed extract results in an increased safety profile while maintaining immunogenicity
Chemical modification of ragweed extract results in an increased safety profile while maintaining immunogenicity Open
Short or common ragweed (Ambrosia artemisiifolia), belonging to the plant family of Asteraceae, is an annual weed with pollination peak levels in late summer. Epidemiological studies revealed a sensitization prevalence of 23%–32.8% for the…
View article: Identification and Physicochemical Characterization of a New Allergen from Ascaris lumbricoides
Identification and Physicochemical Characterization of a New Allergen from Ascaris lumbricoides Open
To analyze the impact of Ascaris lumbricoides infection on the pathogenesis and diagnosis of allergic diseases, new allergens should be identified. We report the identification of a new Ascaris lumbricoides allergen, Asc l 5. The aim of th…
View article: Identification of a new, no cross-reacting allergen from Ascaris lumbricoides
Identification of a new, no cross-reacting allergen from Ascaris lumbricoides Open
In the tropics, both ascariasis and allergic diseases are highly prevalent. To better analyze the potential impact of Ascaris infection on the pathogenesis and diagnosis of allergic diseases, it is necessary to identify and characterize ne…
View article: Peptidase PepP is a novel virulence factor of <i>Campylobacter jejuni</i> contributing to murine campylobacteriosis
Peptidase PepP is a novel virulence factor of <i>Campylobacter jejuni</i> contributing to murine campylobacteriosis Open
Mechanisms of host-pathogen interactions resulting in immunopathological responses upon human Campylobacter jejuni infection are not completely understood, but the recent availability of murine infection models mimicking key features of ca…
View article: Effect of structural stability on endolysosomal degradation and T‐cell reactivity of major shrimp allergen tropomyosin
Effect of structural stability on endolysosomal degradation and T‐cell reactivity of major shrimp allergen tropomyosin Open
Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross‐reactivity. Despite sequence similarities, their allergenicity varies greatly between ingested and inhaled inve…
View article: A hybrid of two major <i>Blomia tropicalis</i> allergens as an allergy vaccine candidate
A hybrid of two major <i>Blomia tropicalis</i> allergens as an allergy vaccine candidate Open
Introduction Allergen‐specific immunotherapy (AIT) represents a curative approach for treating allergies. In the tropical and subtropical regions of the world, Blomia tropicalis (Blo t 5 and Blo t 21) is the likely dominant source of indoo…
View article: Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin
Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin Open
Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross-reactivity. Despite structural similarities, their allergenicity varies greatly between ingested and inhaled in…
View article: Similar Allergenicity to Different Artemisia Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules
Similar Allergenicity to Different Artemisia Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules Open
Background and objectives: Pollens of weeds are relevant elicitors of type I allergies. While many Artemisia species occur worldwide, allergy research so far has only focused on Artemisia vulgaris. We aimed to characterize other prevalent …
View article: Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity
Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity Open
Background Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has been identified as the major birch pollen allergen. However, the molecular mechanisms of birch allergic sensitization, including the roles of Bet v …