Peter C. Emmel
YOU?
Author Swipe
View article: Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells
Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells Open
The cytokine interleukin-2 (IL-2) has the potential to treat autoimmune disease but is limited by its modest specificity toward immunosuppressive regulatory T (T reg ) cells. IL-2 receptors consist of combinations of α, β, and γ chains of …
View article: Multivalent, asymmetric IL-2-Fc fusions provide optimally enhanced regulatory T cell selectivity
Multivalent, asymmetric IL-2-Fc fusions provide optimally enhanced regulatory T cell selectivity Open
The common γ-chain receptor cytokines coordinate the proliferation and function of immune cell populations. One of these cytokines, interleukin (IL)-2, has potential as a therapy in autoimmune disease but is limited in effectiveness by its…