Peter D. Sly
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View article: A Composite Epigenetic Biomarker of <i>FOXP3</i> / <i>TIGIT</i> Correlates With Regulatory T Cell Numbers in Cord Blood and Is Associated With Subsequent Food Allergy
A Composite Epigenetic Biomarker of <i>FOXP3</i> / <i>TIGIT</i> Correlates With Regulatory T Cell Numbers in Cord Blood and Is Associated With Subsequent Food Allergy Open
Background Flow cytometry studies have reported an association between lower regulatory T cells (Treg) in cord blood and subsequent food allergy. Flow cytometry, however, is a resource‐intensive technique. We therefore aimed to develop an …
View article: Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies
Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies Open
Phthalates and bisphenols may contribute to childhood allergic outcomes, but whether these are differentially associated with atopic or non-atopic phenotypes is uncertain. We investigated whether early-life exposure to these chemicals diff…
View article: The effects of bushfire smoke exposure on oxidative stress and inflammatory biomarkers: a systematic review
The effects of bushfire smoke exposure on oxidative stress and inflammatory biomarkers: a systematic review Open
Introduction Bushfire smoke (BFS) is an escalating global health concern, with increasing bushfire frequency due to climate change. Exposure to BFS significantly impacts public health due to worsening respiratory and cardiovascular conditi…
View article: Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes
Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes Open
Background In utero mechanisms related to oxidative stress response, inflammation, and extracellular matrix turnover may influence fetal lung development in the offspring of asthmatic mothers. Therefore, we aimed to determine whether level…
View article: Trends and gaps in air quality and children's health: A biblio-metric analysis using scopus and VOSviewer
Trends and gaps in air quality and children's health: A biblio-metric analysis using scopus and VOSviewer Open
Air pollution remains a critical global health issue that affects children. This bibliometric study analyses trends, research gaps, and key contributors to the literature on air pollution’s impact on children’s health, utilizing data from …
View article: Finding the optimal regimen for <i>Mycobacteroides abscessus</i> treatment (FOR<i>Ma</i>T) in people with <i>Mycobacteroides abscessus</i> pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial
Finding the optimal regimen for <i>Mycobacteroides abscessus</i> treatment (FOR<i>Ma</i>T) in people with <i>Mycobacteroides abscessus</i> pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial Open
Introduction Mycobacteroides abscessus (MABS) is within the non-tuberculous mycobacteria family. It inhabits soil and water, exhibits multi-antibiotic resistance and causes opportunistic lung infections, which may progress to symptomatic M…
View article: 579. SOCIOECONOMIC ADVERSITY, MATERNAL NUTRITION, AND THE PRENATAL PROGRAMMING OF CHILD COGNITION AND LANGUAGE AT TWO YEARS OF AGE THROUGH MATERNAL INFLAMMATION
579. SOCIOECONOMIC ADVERSITY, MATERNAL NUTRITION, AND THE PRENATAL PROGRAMMING OF CHILD COGNITION AND LANGUAGE AT TWO YEARS OF AGE THROUGH MATERNAL INFLAMMATION Open
Background The adverse effect of socioeconomic adversity on offspring cognition may be mediated through elevated prenatal maternal inflammation, but the role of modifiable antecedents such as nutrition has not been clarified. Aims & Object…
View article: Prenatal Environmental Determinants of Aromatase Brain-Promoter Methylation in Cord Blood: Chemical, Airborne, Pharmacological, and Nutritional Factors
Prenatal Environmental Determinants of Aromatase Brain-Promoter Methylation in Cord Blood: Chemical, Airborne, Pharmacological, and Nutritional Factors Open
Aromatase, an enzyme encoded by the gene CYP19A1 , plays central roles in neurodevelopment. In the brain, its function is to convert androgens into neuroestrogens, ensuring balanced hormonal signalling. Both animal experiments and human st…
View article: Phthalates, bisphenols and per-and polyfluoroalkyl substances migration from food packaging into food: a systematic review
Phthalates, bisphenols and per-and polyfluoroalkyl substances migration from food packaging into food: a systematic review Open
Endocrine-disrupting chemicals are commonly found in food due to their migration from plastic packaging. Despite their functional benefits, these additives can disrupt the endocrine system, leading to several adverse health outcomes. This …
View article: Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosis
Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosis Open
Funded by Medical Researcher Futures Fund Australia (GA89314), The University of Queensland, Wesley Research Institute, and BrAshA-T.
View article: Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies
Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies Open
Background Exposure to plastic additives, such as phthalates and bisphenols, has been associated with a higher risk of allergic conditions, but the evidence is inconsistent for children younger than five. Objective To examine the associati…
View article: Artificial Intelligence-assisted Pixel-level Lung (APL) Scoring for Fast and Accurate Quantification in Ultra-short Echo-time MRI
Artificial Intelligence-assisted Pixel-level Lung (APL) Scoring for Fast and Accurate Quantification in Ultra-short Echo-time MRI Open
Lung magnetic resonance imaging (MRI) with ultrashort echo-time (UTE) represents a recent breakthrough in lung structure imaging, providing image resolution and quality comparable to computed tomography (CT). Due to the absence of ionising…
View article: Associations between household characteristics and environmentally persistent free radicals in house dust from two Australian locations
Associations between household characteristics and environmentally persistent free radicals in house dust from two Australian locations Open
Introduction The association between air pollution and adverse health outcomes has been extensively documented, with oxidative stress widely considered a contributing factor. However, the precise underlying mechanism(s) remains unclear. Re…
View article: Early‐life allergic sensitization and respiratory infection—Two hits on lung function?
Early‐life allergic sensitization and respiratory infection—Two hits on lung function? Open
Background Allergic sensitization and respiratory infections commonly occur in childhood. Interplay between them in asthma development is known as the ‘two‐hit’ hypothesis. There has been no previous investigation of this hypothesis on adu…
View article: Correction: Rame Hau et al. The Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-Urban Dairy Cattle Farms in Kathmandu, Nepal. Antibiotics 2025, 14, 98
Correction: Rame Hau et al. The Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-Urban Dairy Cattle Farms in Kathmandu, Nepal. Antibiotics 2025, 14, 98 Open
There were errors in the original publication [...]
View article: Household dust as a reservoir for environmentally persistent free radicals: a longitudinal study
Household dust as a reservoir for environmentally persistent free radicals: a longitudinal study Open
Epidemiological links between air pollution and adverse health outcomes are strong, but the mechanism(s) remain obscure. A newly recognised combustion by-product, environmentally persistent free radicals (EPFRs), may be the missing link. T…
View article: Phthalates, Bisphenols, and Childhood Allergic Phenotypes: Findings from Two Birth Cohort Studies
Phthalates, Bisphenols, and Childhood Allergic Phenotypes: Findings from Two Birth Cohort Studies Open
Background Phthalates and bisphenols may contribute to childhood allergic outcomes, but whether these are differentially associated with atopic or non-atopic phenotypes is uncertain. We investigated whether early-life exposure to these che…
View article: Nasal transcriptome differences preceding recurrent wheezing in infancy
Nasal transcriptome differences preceding recurrent wheezing in infancy Open
The nasal transcriptome in early infancy is associated with subsequent recurrent wheezes, indicating upregulation of immune cell chemotaxis, decreased epithelial barrier function, and altered cilium organization and mitochondrial function.…
View article: Polyphenol Intake During Pregnancy and Childhood Asthma and Atopic Disorders: A Systematic Review
Polyphenol Intake During Pregnancy and Childhood Asthma and Atopic Disorders: A Systematic Review Open
View article: Prenatal DEHP plastic chemical exposure increases the likelihood of child autism and ADHD symptoms through epigenetic programming
Prenatal DEHP plastic chemical exposure increases the likelihood of child autism and ADHD symptoms through epigenetic programming Open
Increasing evidence implicates prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP), a common endocrine-disrupting plastic chemical, in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). However, the und…
View article: Emergency department presentations related to asthma and allergic diseases in Central Queensland, Australia: a comparative analysis between First Nations Australians and Australians of other descents
Emergency department presentations related to asthma and allergic diseases in Central Queensland, Australia: a comparative analysis between First Nations Australians and Australians of other descents Open
Objective To examine the overall incidence rate and trends in emergency department (ED) presentations related to asthma and allergic diseases in regional Australia with a particular focus on First Nations Australians. Design A retrospectiv…
View article: Infant respiratory outcomes following asthma management and exacerbations in pregnancy
Infant respiratory outcomes following asthma management and exacerbations in pregnancy Open
Background Improved maternal asthma management in pregnancy may reduce recurrent bronchiolitis and wheeze outcomes in infancy. We assessed whether infant bronchiolitis and wheeze outcomes are influenced by inflammation-guided management in…
View article: Astaxanthin protects against environmentally persistent free radical-induced oxidative stress in well-differentiated respiratory epithelium
Astaxanthin protects against environmentally persistent free radical-induced oxidative stress in well-differentiated respiratory epithelium Open
Environmentally persistent free radicals (EPFRs) are combustion products present in substantial numbers on atmospheric particulate matter with half-lives of days to years. The mechanisms linking EPFR exposure and respiratory diseases are u…
View article: Development and clinical assessment of a novel probiotic candy in the prevention of respiratory infections in asthmatic children
Development and clinical assessment of a novel probiotic candy in the prevention of respiratory infections in asthmatic children Open
Adding spore-forming probiotic candy containing Bacillus coagulans to standard asthma treatments reduced symptomatic respiratory illnesses over two months. Further studies including longer treatment periods are needed before making …
View article: The Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-Urban Dairy Cattle Farms in Kathmandu, Nepal
The Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-Urban Dairy Cattle Farms in Kathmandu, Nepal Open
Background/Objectives: The presence of antibiotic residues (ARs) in animal products such as milk can be an important driver of antimicrobial resistance in commensal and pathogenic bacteria. Previous studies on ARs in Nepal have demonstrate…
View article: Prenatal Exposure to the Plasticizer DEHP Increases the Likelihood of Early-Life Autism and ADHD Symptoms Through Epigenetic Programming
Prenatal Exposure to the Plasticizer DEHP Increases the Likelihood of Early-Life Autism and ADHD Symptoms Through Epigenetic Programming Open
View article: Ataxia-Telangiectasia: Treating Mitochondrial Dysfunction with a Novel Form of Anaplerosis (A-TC7)
Ataxia-Telangiectasia: Treating Mitochondrial Dysfunction with a Novel Form of Anaplerosis (A-TC7) Open
View article: A pathway-based genetic score for inflammation: An indicator of vulnerability to phthalate-induced adverse neurodevelopment outcomes
A pathway-based genetic score for inflammation: An indicator of vulnerability to phthalate-induced adverse neurodevelopment outcomes Open
These findings contribute to the evidence linking gestational phthalate exposure and inflammation to adverse neurodevelopment and underscoring increased risks in children with higher genetic susceptibility to inflammation.
View article: Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-urban Dairy Cattle Farms of Kathmandu, Nepal
Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-urban Dairy Cattle Farms of Kathmandu, Nepal Open
The presence of antibiotic residues (AR) in animal products such as milk can be an important driver of antimicrobial resistance in commensal and pathogenic bacteria. Previous studies on ARs in Nepal have demonstrated the presence of ARs in…
View article: Virome assembly reveals draft genomes of native Pseudomonas phages isolated from a paediatric bronchoalveolar lavage sample
Virome assembly reveals draft genomes of native Pseudomonas phages isolated from a paediatric bronchoalveolar lavage sample Open
We present lung virome data recovered through shotgun metagenomics in bronchoalveolar lavage fluid from an infant with cystic fibrosis, who tested positive for Stenotrophomonas maltophilia infection. Using a bioinformatic pipeline for viru…