Peter D. Yim
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β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation Open
This research investigates β-ionone’s potential as a therapeutic agent for bronchoconstriction. It sheds light on the mechanism of action of β-ionone’s activation of extraocular opsin-3 receptors, offering insights into dietary influences …
Light-Mediated Inhibition of Colonic Smooth Muscle Constriction and Colonic Motility via Opsin 3 Open
Opsin photoreceptors outside of the central nervous system have been shown to mediate smooth muscle photorelaxation in several organs. We hypothesized that opsin receptor activation in the colon would have a similar effect and influence co…
View article: Plasma biomarkers associated with survival and thrombosis in hospitalized COVID-19 patients
Plasma biomarkers associated with survival and thrombosis in hospitalized COVID-19 patients Open
Severe coronavirus disease-19 (COVID-19) has been associated with fibrin-mediated hypercoagulability and thromboembolic complications. To evaluate potential biomarkers of coagulopathy and disease severity in COVID-19, we measured plasma le…
Anesthetic Management for Endovascular Treatment of Stroke in Patients With Coronavirus Disease 2019: A Case Series Open
A significant number of patients with coronavirus disease 2019 develop strokes with large vessel obstructions that may require endovascular treatment for revascularization. Our series focuses on periprocedural issues and the anesthetic man…
View article: Androgen regulation of bowel function in mice and humans
Androgen regulation of bowel function in mice and humans Open
Summary Many digestive disorders have prominent sex differences in incidence, symptomatology, and treatment response that are not well understood. Irritable bowel syndrome (IBS), for example, affects approximately 10% of the population wor…
Opsin 3–G <sub>αs</sub> Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2 Open
Recently, we characterized blue light-mediated relaxation (photorelaxation) of airway smooth muscle (ASM) and implicated the involvement of opsin 3 (OPN3), an atypical opsin. In the present study, we characterized the cellular signaling me…
An isolated retrograde-perfused newborn mouse heart preparation Open
The Langendorff-perfused model is a powerful tool to study biological responses in the isolated heart in the absence of confounders. The model has been adapted recently to enable study of the isolated mouse heart and the effects of genetic…
Novel Expression of GABAA Receptors on Resistance Arteries That Modulate Myogenic Tone Open
The clinical administration of GABAergic medications leads to hypotension which has classically been attributed to the modulation of neuronal activity in the central and peripheral nervous systems. However, certain types of peripheral smoo…
Airway smooth muscle photorelaxation via opsin receptor activation Open
Nonvisual opsin (OPN) receptors have recently been implicated in blue light-mediated photorelaxation of smooth muscle in various organs. Since photorelaxation has not yet been demonstrated in airway smooth muscle (ASM) or in human tissues,…