Peter Deplazes
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View article: Comprehensive Survival Analysis of Alveolar Echinococcosis Patients, University Hospital Zurich, Zurich, Switzerland, 1973–2022
Comprehensive Survival Analysis of Alveolar Echinococcosis Patients, University Hospital Zurich, Zurich, Switzerland, 1973–2022 Open
Alveolar echinococcosis (AE) is a zoonotic disease of increasing concern worldwide. Before benzimidazole drug therapy, 10-year death rates were 90% without surgical resection. In unresectable patients, long-term benzimidazole therapy is hi…
View article: Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of Echinococcus multilocularis
Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of Echinococcus multilocularis Open
Alveolar echinococcosis (AE) caused by Echinococcus multilocularis , is a severe zoonotic disease in humans. One of the major metacestode antigens of E. multilocularis is the Em2 or Em2(G11) native purified antigen. The Em2 antigen is used…
View article: The burden and distribution of cystic echinococcosis in Bhutan: a retrospective study
The burden and distribution of cystic echinococcosis in Bhutan: a retrospective study Open
Cystic echinococcosis (CE), caused by Echinococcus granulosus s.l. is a neglected zoonosis posing a significant public health challenge. Little is known about human CE in Bhutan. This study was conducted to gain an understanding of the bur…
View article: Environmental contamination with feces of free-roaming dogs and the risk of transmission of Echinococcus and Taenia species in urban regions of southeastern Iran
Environmental contamination with feces of free-roaming dogs and the risk of transmission of Echinococcus and Taenia species in urban regions of southeastern Iran Open
Background Dogs are the most important definitive hosts of zoonotic taeniid helminths worldwide. Different Echinococcus and Taenia species of domestic and wild carnivores pose a potential risk to human population. High populations of free-…
View article: Histopathological assessment of the viability of hepatic alveolar echinococcosis
Histopathological assessment of the viability of hepatic alveolar echinococcosis Open
Aims Infections by the larval stage of the tape worms Echinococcus multilocularis and Echinococcus granulosus s.l . are potentially fatal zoonoses affecting humans as dead‐end hosts. Histopathological evaluation of hepatic echinococcosis i…
View article: Detection of<i>Echinococcus</i>spp. and other taeniid species in lettuces and berries: two international multicenter studies from the MEmE project
Detection of<i>Echinococcus</i>spp. and other taeniid species in lettuces and berries: two international multicenter studies from the MEmE project Open
Cystic and alveolar echinococcosis are severe zoonotic diseases characterized by long asymptomatic periods lasting months or years. Viable Echinococcus eggs released into the environment through the feces of canids can infect humans throug…
View article: Immunohistochemistry as a Reliable Tool for the Diagnosis of Cystic Echinococcosis in Patients from Sardinia, Italy—A Confirmatory Study
Immunohistochemistry as a Reliable Tool for the Diagnosis of Cystic Echinococcosis in Patients from Sardinia, Italy—A Confirmatory Study Open
Cystic Echinococcosis (CE) is a zoonotic disease caused by the larval stage of the tapeworm Echinococcus granulosus sensu lato (s.l.). This study aims to investigate the use of two monoclonal antibodies (mAbEmG3 and mAbEm2G11) by immunohis…
View article: Environmental distribution of <i>Echinococcus</i>- and <i>Taenia</i> spp.-contaminated dog feces in Kyrgyzstan
Environmental distribution of <i>Echinococcus</i>- and <i>Taenia</i> spp.-contaminated dog feces in Kyrgyzstan Open
Recently, there have been epidemics of human cystic echinococcosis (CE) and alveolar echinococcosis (AE) in Kyrgyzstan. This study investigated 2 districts for the presence of Echinococcus granulosus s.l. and Echinococcus multilocularis eg…
View article: Management of biliary obstruction in patients with newly diagnosed alveolar echinococcosis: a Swiss retrospective cohort study
Management of biliary obstruction in patients with newly diagnosed alveolar echinococcosis: a Swiss retrospective cohort study Open
BACKGROUND AND STUDY AIMS: Alveolar echinococcosis, an orphan zoonosis affecting the liver, is of increasing concern worldwide. Most symptomatic cases present at an advanced and inoperable stage, sometimes with biliary obstruction promptin…
View article: First isolation of <i>Echinococcus granulosus sensu lato</i> genotype 7 in the archipelago of Cape Verde
First isolation of <i>Echinococcus granulosus sensu lato</i> genotype 7 in the archipelago of Cape Verde Open
There are no scientific data available on the occurrence of the Echinococcus granulosus sensu lato ( s.l. ) cluster in definitive hosts (domestic dogs), intermediate hosts (domestic livestock) nor humans in Cape Verde. In this pilot study,…
View article: Differences in clinical aspects of human cystic echinococcosis caused by <i>Echinococcus granulosus sensu stricto</i> and the G6 genotype in Neuquén, Argentina
Differences in clinical aspects of human cystic echinococcosis caused by <i>Echinococcus granulosus sensu stricto</i> and the G6 genotype in Neuquén, Argentina Open
Most human cystic echinococcosis (CE) cases worldwide are attributed to Echinococcus granulosus sensu stricto ( s.s ), followed by the G6 and G7 genotypes. While E. granulosus s.s. has a cosmopolitan distribution, the G6 genotype is restri…
View article: Monoclonal antibody-based localization of major diagnostic antigens in metacestode tissue, excretory/secretory products, and extracellular vesicles of Echinococcus species
Monoclonal antibody-based localization of major diagnostic antigens in metacestode tissue, excretory/secretory products, and extracellular vesicles of Echinococcus species Open
Alveolar (AE) and cystic echinococcosis (CE) are severe parasitic zoonoses caused by the larval stages of Echinococcus multilocularis and E. granulosus sensu lato , respectively. A panel of 7 monoclonal antibodies (mAbs) was selected again…
View article: An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily
An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily Open
Fasciolosis is a worldwide parasitic disease of ruminants and an emerging human disease caused by the liver fluke Fasciola hepatica. The cystatin superfamily of cysteine protease inhibitors is composed of distinct families of intracellular…
View article: Serological Assays for Alveolar and Cystic Echinococcosis—A Comparative Multi-Test Study in Switzerland and Kyrgyzstan
Serological Assays for Alveolar and Cystic Echinococcosis—A Comparative Multi-Test Study in Switzerland and Kyrgyzstan Open
Both alveolar (AE) and cystic echinococcosis (CE) are lacking pathognomonic clinical signs; consequently imaging technologies and serology remain the main pillars for diagnosis. The present study included 100 confirmed treatment-naïve AE a…
View article: Characteristics and Clinical Course of Alveolar Echinococcosis in Patients with Immunosuppression-Associated Conditions: A Retrospective Cohort Study
Characteristics and Clinical Course of Alveolar Echinococcosis in Patients with Immunosuppression-Associated Conditions: A Retrospective Cohort Study Open
Objectives: Since the change in the millennium, an increase in cases of alveolar echinococcosis (AE) has been observed in endemic European countries. Previous studies indicate that a significant proportion of the new AE cases have an immun…
View article: Evaluation of a structured treatment discontinuation in patients with inoperable alveolar echinococcosis on long-term benzimidazole therapy: A retrospective cohort study
Evaluation of a structured treatment discontinuation in patients with inoperable alveolar echinococcosis on long-term benzimidazole therapy: A retrospective cohort study Open
Objectives Alveolar echinococcosis (AE) is an orphan zoonosis of increasing concern in endemic areas, including Europe. It frequently presents in an advanced, inoperable stage, that requires life-long parasitostatic benzimidazole therapy. …
View article: LAMP Assay for the Detection of Echinococcus multilocularis Eggs Isolated from Canine Faeces by a Cost-Effective NaOH-Based DNA Extraction Method
LAMP Assay for the Detection of Echinococcus multilocularis Eggs Isolated from Canine Faeces by a Cost-Effective NaOH-Based DNA Extraction Method Open
The detection of Echinococcus multilocularis in infected canids and the environment is pivotal for a better understanding of the epidemiology of alveolar echinococcosis in endemic areas. Necropsy/sedimentation and counting technique remain…
View article: Association between environmental and climatic risk factors and the spatial distribution of cystic and alveolar echinococcosis in Kyrgyzstan
Association between environmental and climatic risk factors and the spatial distribution of cystic and alveolar echinococcosis in Kyrgyzstan Open
Background Cystic and alveolar echinococcosis (CE and AE) are neglected tropical diseases caused by Echinococcus granulosus sensu lato and E . multilocularis , and are emerging zoonoses in Kyrgyzstan. In this country, the spatial distribut…
View article: Past and present of cystic echinococcosis in Bolivia
Past and present of cystic echinococcosis in Bolivia Open
Viable eggs of the canine intestinal tapeworm Echinococcus granulosus sensu lato ( s . l .) infect various intermediate hosts causing cystic echinococcosis (CE). Furthermore, CE represents a serious zoonosis causing a significant global bu…
View article: Investigation of the occurrence of <i>Angiostrongylus vasorum</i> in coyotes in southern Ontario, Canada
Investigation of the occurrence of <i>Angiostrongylus vasorum</i> in coyotes in southern Ontario, Canada Open
In North America, the only endemic focus for Angiostrongylus vasorum (French heartworm) was historically thought to occur in the southeastern part of the island of Newfoundland. However, reports of A. vasorum infection in wild canids in We…