Peter Deraska
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View article: Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons Open
View article: MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity Open
To identify genes whose loss confers resistance to CHK1 inhibitors, we perform genome-wide CRISPR-Cas9 screens in non-small-cell lung cancer (NSCLC) cell lines treated with the CHK1 inhibitor prexasertib (CHK1i). Five of the top six hits o…
View article: ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells Open
View article: Additional file 3 of Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons
Additional file 3 of Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons Open
Additional file 3: Table S2. Clinical samples and results of assays for SARS-CoV-2 and human RNA.
View article: Additional file 2 of Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons
Additional file 2 of Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons Open
Additional file 2: Table S1. Oligonucleotides used in the LAMP-BEAC assay.
View article: ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells Open
The response to Poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair mechanisms and the abundance of lesions that trap PARP enzymes on chromatin. It remains unclear, however, if the establ…
View article: CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress Open
View article: LAMP-BEAC: Detection of SARS-CoV-2 RNA Using RT-LAMP and Molecular Beacons
LAMP-BEAC: Detection of SARS-CoV-2 RNA Using RT-LAMP and Molecular Beacons Open
Background Rapid spread of SARS-CoV-2 has led to a global pandemic, resulting in the need for rapid assays to allow diagnosis and prevention of transmission. Reverse Transcription-Polymerase Chain Reaction (RT-PCR) provides a gold standard…
View article: NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair
NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair Open
View article: Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer
Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer Open
View article: Circulating MicroRNA Profiling for Thoracic Radiation Therapy Biomarkers
Circulating MicroRNA Profiling for Thoracic Radiation Therapy Biomarkers Open
View article: USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1
USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1 Open
These data support the use of MCL1 expression as a predictive biomarker for USP9X inhibitors in NSCLC therapy.