Peter Bou Dib
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View article: <i>Drosophila</i>MIC10b can polymerize into cristae-shaping filaments
<i>Drosophila</i>MIC10b can polymerize into cristae-shaping filaments Open
Cristae are invaginations of the mitochondrial inner membrane that are crucial for cellular energy metabolism. The formation of cristae requires the presence of a protein complex known as MICOS, which is conserved across eukaryotic species…
The Drosophila MIC10 orthologue has a propensity to polymerize into cristae-shaping filaments Open
Mitochondria are essential eukaryotic double-membrane organelles. The convoluted mitochondrial inner membrane forms highly organized invaginations, termed cristae, which are crucial for energy metabolism. Cristae formation requires MICOS, …
Towards a templated reaction that translates RNA in cells into a proaptotic peptide‐PNA conjugate Open
Nucleic acid‐templated chemistry opens the intriguing prospect of triggering the synthesis of drugs only in diseased cells. Herein, we explore the feasibility of using RNA‐templated chemical reactions for the activation of a known Smac pep…
ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo Open
Signs of proteostasis failure often entwine with those of metabolic stress at the cellular level. Here, we study protein sequestration during glucose deprivation-induced ATP decline in Saccharomyces cerevisiae . Using live-cell imaging, we…
Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor Open
The degeneration of dopaminergic (DA) neurons in the substantia nigra is a hallmark of Parkinson’s disease (PD). Dysregulation of developmental transcription factors is implicated in dopaminergic neurodegeneration, but the underlying molec…
View article: Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling
Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling Open
Heat-induced hormesis is a well-known conserved phenomenon in aging, traditionally attributed to the benefits conferred by increased amounts of heat shock (HS) proteins. Here we find that the key event for the HS-induced lifespan extension…
Normal mitochondrial function in Saccharomyces cerevisiae has become dependent on inefficient splicing Open
Self-splicing introns are mobile elements that have invaded a number of highly conserved genes in prokaryotic and organellar genomes. Here, we show that deletion of these selfish elements from the Saccharomyces cerevisiae mitochondrial gen…
View article: <scp>TORC</scp> 1‐mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
<span>TORC</span> 1‐mediated sensing of chaperone activity alters glucose metabolism and extends lifespan Open
Summary Protein quality control mechanisms, required for normal cellular functioning, encompass multiple functions related to protein production and maintenance. However, the existence of communication between proteostasis and metabolic ne…