Peter C. Doherty
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View article: HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes
HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes Open
Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in n…
View article: Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan
Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan Open
Central memory CD8 + T cells (T cm ) represent the prominent memory T cell subset in human blood, yet the persistence of T cell receptor (TCR) clonotypic and transcriptional features of epitope-specific T cm pools across the human lifespan…
View article: NSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1)
NSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1) Open
We report on the observation and measurement of astrometry, photometry, morphology, and activity of the interstellar object 3I/ATLAS, also designated C/2025 N1 (ATLAS), with the NSF-DOE Vera C. Rubin Observatory. The third interstellar obj…
View article: Ending nuclear weapons, before they end us
Ending nuclear weapons, before they end us Open
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View article: Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors Open
Cross-reactive αβ T cell receptors (TCRs) recognizing multiple peptide variants can provide effective control of rapidly evolving viruses yet remain understudied. By screening 12 naturally occurring influenza-derived HLA-B*35:01–restricted…
View article: SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years
SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years Open
Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-Co…
View article: Killer T Cells: Immune System Heroes
Killer T Cells: Immune System Heroes Open
This article is based on an interview between the two authors. The human body is like a jungle, with trillions of fascinating things happening inside it every second, most of which occur without our awareness. In this article, we will zoom…
View article: Immunology and innovation: Peter Doherty’s life in science
Immunology and innovation: Peter Doherty’s life in science Open
In 1996, over two decades after their discovery of how killer T cells recognise virusinfected cells, Peter Doherty and Rolf M Zinkernagel were awarded a Nobel Prize for their contribution to the field of immunology.Now Doherty, the author …
View article: The Edge of Life: Controversies and challenges in human health
The Edge of Life: Controversies and challenges in human health Open
View article: Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians
Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians Open
Significance Indigenous populations worldwide are highly susceptible to influenza virus infections. Vaccination with inactivated virus is highly recommended to protect Indigenous populations, including Indigenous Australians. There is no s…
View article: The origins of SARS-CoV-2: A critical review
The origins of SARS-CoV-2: A critical review Open
Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2…
View article: Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells.
Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells. Open
The lysosomal storage disorder galactosialidosis results from a primary deficiency of the protective protein/cathepsin A (PPCA), which in turn affects the activities of beta-galactosidase and neuraminidase. Mice homozygous for a null mutat…
View article: About the Master
About the Master Open
in 1990 and to St. Jude in 2005.His research has focused on the process of active cell death and cell survival, extending from the role of cell death in the regulation of cancer and immune responses in the whole organism to the fundamental…
View article: In-concert immune dynamics during natural influenza virus infection and recovery in acute hospitalized patients
In-concert immune dynamics during natural influenza virus infection and recovery in acute hospitalized patients Open
We report in-concert dynamics of 18 key immune parameters, related to clinical, genetic and virological factors, in patients hospitalized with influenza across different severity levels. Influenza disease was associated with correlated inc…
View article: Suboptimal SARS-CoV-2−specific CD8 <sup>+</sup> T cell response associated with the prominent HLA-A*02:01 phenotype
Suboptimal SARS-CoV-2−specific CD8 <sup>+</sup> T cell response associated with the prominent HLA-A*02:01 phenotype Open
Significance As the recall of CD8 + T cell memory promotes rapid recovery in, for example, influenza, we investigated circulating SARS-CoV-2−specific CD8 + T cells from COVID-19 patients. For two HLA-A*02:01 SARS-CoV-2−specific CD8 + T cel…
View article: Suboptimal SARS-CoV-2-specific CD8<sup>+</sup> T-cell response associated with the prominent HLA-A*02:01 phenotype
Suboptimal SARS-CoV-2-specific CD8<sup>+</sup> T-cell response associated with the prominent HLA-A*02:01 phenotype Open
An improved understanding of human T-cell-mediated immunity in COVID-19 is important if we are to optimize therapeutic and vaccine strategies. Experience with influenza shows that infection primes CD8 + T-cell memory to shared peptides pre…
View article: The Origin of COVID-19 and Why It Matters
The Origin of COVID-19 and Why It Matters Open
The COVID-19 pandemic is among the deadliest infectious diseases to have emerged in recent history. As with all past pandemics, the specific mechanism of its emergence in humans remains unknown. Nevertheless, a large body of virologic, epi…
View article: Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses
Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses Open
Persistent and durable immunological memory forms the basis of any successful vaccination protocol. Generation of pre-existing memory B cell and T cell pools is thus the key for maintaining protective immunity to seasonal, pandemic and avi…
View article: Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation
Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation Open
Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T cells…
View article: Potential killers exposed: tracking endogenous influenza‐specific CD8<sup>+</sup> T cells
Potential killers exposed: tracking endogenous influenza‐specific CD8<sup>+</sup> T cells Open
Current influenza A virus (IAV) vaccines stimulate antibody responses that are directed against variable regions of the virus, and are therefore ineffective against divergent strains. As CD8 + T cells target the highly conserved, internal …