Explanipedia

Quantitative Structure Use Relationships: Highlights from a technical summit meeting Open

Rosemary Zaleski, Andreas Ahrens, Jon A. Arnot, Richard A. Becker, Mark Bonnell , et al. · 2023

Cutting-edge computational chemical exposure research at the U.S. Environmental Protection Agency Open

Timothy J. Buckley, Peter Egeghy, Kristin Isaacs, Ann M. Richard, Caroline Ring , et al. · 2023

The chemical landscape of high-throughput new approach methodologies for exposure Open

Kristin Isaacs, Peter Egeghy, Kathie L. Dionisio, Katherine A. Phillips, Angelika Zidek , et al. · 2022

Exposure Prioritization (Ex Priori): A Screening-Level High-Throughput Chemical Prioritization Tool Open

Heidi Hubbard, Caroline Ring, Tao Hong, Cara Henning, Daniel A. Vallero , et al. · 2022

To estimate potential chemical risk, tools are needed to prioritize potential exposures for chemicals with minimal data. Consumer product exposures are a key pathway, and variability in consumer use patterns is an important factor. We desi…

Pilot study of consumer product chemicals measured using silicone wristband monitors Open

Peter Egeghy, Timothy J. Buckley, Daniel M. Stout, Kyla W. Taylor, Steven E. Prince , et al. · 2022

Presentation to ISEE in Athens Greece on Sept 18-21, 2022 Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&da…

Inadvertently Generated PCBs in Consumer Products: Concentrations, Fate and Transport, and Preliminary Exposure Assessment Open

Xiaoyu Liu, Michelle R. Mullin, Peter Egeghy, Katherine A. Woodward, Kathleen C. Compton , et al. · 2022

Although commercial polychlorinated biphenyl (PCB) production was banned in 1979 under the Toxics Substance Control Act, inadvertent generation of PCBs through a variety of chemical production processes continues to contaminate products an…

Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies Open

Kelly Lowe, Jeffrey L. Dawson, Katherine A. Phillips, Jeffrey M. Minucci, John F. Wambaugh , et al. · 2021

Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment Open

Yu‐Mei Tan, Hugh A. Barton, Alan R. Boobis, Rachel Brunner, Harvey J. Clewell , et al. · 2021

Integrating Personal Air Sensor and GPS to Determine Microenvironment-Specific Exposures to Volatile Organic Compounds Open

Michael S. Breen, Vlad Isakov, Steven E. Prince, Kennedy L McGuinness, Peter Egeghy , et al. · 2021

Personal exposure to volatile organic compounds (VOCs) from indoor sources including consumer products is an understudied public health concern. To develop and evaluate methods for monitoring personal VOC exposures, we performed a pilot st…

Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model Open

Alexander W East, Peter Egeghy, Elaine A. Cohen Hubal, Rachel Slover, Daniel A. Vallero · 2021

The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure Open

Juei-Chuan Kang-Sickel, Mary Ann Butler, Lynn T. Frame, Berrin Serdar, Yi‐Chun Chao , et al. · 2021

We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and…

Ex Priori: A Screening-Level Chemical Prioritization Dashboard for Consumer Exposures Open

Michael‐Rock Goldsmith, Caroline Ring, Heidi Hubbard, Tao Hong, Daniel A. Vallero , et al. · 2021

Presentation to the Society of Toxicology annual meeting March 2021, March 12-26, 2021

Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers Open

Yi-Chun E. Chao, Lawrence L. Kupper, Berrin Serdar, Peter Egeghy, Stephen M. Rappaport , et al. · 2020

Jet propulsion fuel 8 (JP-8) is the major jet fuel used worldwide and has been recognized as a major source of chemical exposure, both inhalation and dermal, for fuel-cell maintenance workers. We investigated the contributions of dermal an…

Toward setting public health guidelines for chemicals in indoor settled dust? Open

Philippe Glorennec, Derek G. Shendell, Pat E. Rasmussen, Roger Waeber, Peter Egeghy , et al. · 2020

Indoor settled dust may result in substantial human exposure to chemicals, especially by ingestion following hand-to-mouth or hand-to-object-to-mouth contact. As with other environmental media related to exposure, dust may thus be subject …

Computational Exposure Science at the Environmental Protection Agency’s Office of Research & Development Open

Peter Egeghy · 2020

Presentation given to the American Chemistry Council’s Long Range Initiative Strategic Science Team virtual meeting June 2020

Enhancing life cycle chemical exposure assessment through ontology modeling Open

David E. Meyer, Sidney C. Bailin, Daniel A. Vallero, Peter Egeghy, Shi V. Liu , et al. · 2019

Establishing a system of consumer product use categories to support rapid modeling of human exposure Open

Kristin Isaacs, Kathie L. Dionisio, Katherine A. Phillips, Charles Bevington, Peter Egeghy , et al. · 2019

Integrating exposure to chemicals in building materials during use stage Open

Lei Huang, Nicholas D. Anastas, Peter Egeghy, Daniel A. Vallero, Olivier Jolliet , et al. · 2018

Qualitative Approach to Comparative Exposure in Alternatives Assessment Open

William Greggs, Thomas Burns, Peter Egeghy, Michelle R. Embry, Peter Fantke , et al. · 2018

Most alternatives assessments (AAs) published to date are largely hazard-based rankings, thereby ignoring potential differences in human and/or ecosystem exposures; as such, they may not represent a fully informed consideration of the adva…

Advances on a Decision Analytic Approach to Exposure‐Based Chemical Prioritization Open

Matthew D. Wood, Kenton Plourde, Sabrina Larkin, Peter Egeghy, Antony Williams , et al. · 2018

The volume and variety of manufactured chemicals is increasing, although little is known about the risks associated with the frequency and extent of human exposure to most chemicals. The EPA and the recent signing of the Lautenberg Act hav…

Aggregate exposure pathways in support of risk assessment Open

Yu‐Mei Tan, Jeremy A. Leonard, Stephen W. Edwards, Justin Teeguarden, Alicia Paini , et al. · 2018

Refining the aggregate exposure pathway Open

Yu‐Mei Tan, Jeremy A. Leonard, Stephen W. Edwards, Justin Teeguarden, Peter Egeghy · 2018

The elements of the aggregate exposure pathway have been refined to better facilitate organization, integration, and dissemination of exposure data.

Using exposure bands for rapid decision making in the RISK21 tiered exposure assessment Open

Michael Dellarco, Rosemary Zaleski, Bonnie Gaborek, Hua Qian, Cheryl A. Bellin , et al. · 2017

The ILSI Health and Environmental Sciences Institute (HESI) Risk Assessment in the Twenty-first Century (RISK21) project was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-ba…

Conceptual Framework To Extend Life Cycle Assessment Using Near-Field Human Exposure Modeling and High-Throughput Tools for Chemicals Open

Susan A. Csiszar, David E. Meyer, Kathie L. Dionisio, Peter Egeghy, Kristin Isaacs , et al. · 2016

Life Cycle Assessment (LCA) is a decision-making tool that accounts for multiple impacts across the life cycle of a product or service. This paper presents a conceptual framework to integrate human health impact assessment with risk screen…

Exploring Global Exposure Factors Resources for Use in Consumer Exposure Assessments Open

Rosemary Zaleski, Peter Egeghy, Pertti J. Hakkinen · 2016

This publication serves as a global comprehensive resource for readers seeking exposure factor data and information relevant to consumer exposure assessment. It describes the types of information that may be found in various official surve…

Integrating exposure into chemical alternatives assessment using a qualitative approach Open

Bill Greggs, Scott Arnold, Thomas J. Burns, Peter Egeghy, Peter Fantke , et al. · 2016

Most alternatives assessments (AA) published to date are largely hazard-based rankings, and as such may not represent a fully informed consideration of the advantages and disadvantages of possible alternatives. With an assessment goal of i…

Characterization and prediction of chemical functions and weight fractions in consumer products Open

Kristin Isaacs, Michael‐Rock Goldsmith, Peter Egeghy, Katherine A. Phillips, Raina D. Brooks , et al. · 2016

Assessing exposures from the thousands of chemicals in commerce requires quantitative information on the chemical constituents of consumer products. Unfortunately, gaps in available composition data prevent assessment of exposure to chemic…

Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment Open

Peter Egeghy, Linda S. Sheldon, Kristin Isaacs, Halûk Özkaynak, Michael‐Rock Goldsmith , et al. · 2015

Egeghy PP, Sheldon LS, Isaacs KK, Özkaynak H, Goldsmith M-R, Wambaugh JF, Judson RS, Buckley TJ. 2016. Computational exposure science: an emerging discipline to support 21st-century risk assessment. Environ Health Perspect 124:697-702; htt…

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