Peter F. Mount
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View article: Glycolytic control proteins in urinary extracellular vesicles are elevated during kidney transplant T cell-mediated rejection
Glycolytic control proteins in urinary extracellular vesicles are elevated during kidney transplant T cell-mediated rejection Open
View article: Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement
Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement Open
In patients with GPA or MPA with kidney involvement, treatment with an avacopan regimen compared with a prednisone taper regimen achieved similar rates of remission, improved recovery of kidney function, led to faster reduction in albuminu…
View article: Lessons from implementation of a nephrology key performance indicator programme
Lessons from implementation of a nephrology key performance indicator programme Open
Background We review the impact of a nephrology key performance indicator (KPI) program implemented over a ten‐year period in Victoria, Australia. The program enabled transparent comparison of performance across nephrology units, however i…
View article: A Pilot, Single-Blinded, Randomized Crossover Trial of Cramp Reduction with Angiotensin II in Maintenance Patients on Hemodialysis (the CRAMP-HD Study)
A Pilot, Single-Blinded, Randomized Crossover Trial of Cramp Reduction with Angiotensin II in Maintenance Patients on Hemodialysis (the CRAMP-HD Study) Open
Introduction: Angiotensin II may reduce muscle ischemia during intermittent hemodialysis (IHD) and thereby decrease the incidence and/or intensity of intradialytic muscle cramps. We aimed to test whether angiotensin II infusion during IHD …
View article: The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury
The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury Open
Acute kidney injury (AKI) disrupts energy metabolism. Targeting metabolism through AMP-activated protein kinase (AMPK) may alleviate AKI. ATX-304, a pan-AMPK activator, was evaluated in C57Bl/6 mice and tubular epithelial cell (TEC) cultur…
View article: The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial
The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial Open
View article: Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia
Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia Open
ENaC expression is upregulated in UEV of pre-eclamptic subjects but was not associated with changes in NEDD4L.
View article: Tunnelled central venous catheters for incident haemodialysis patients: a Victorian survey exploring reasons for use
Tunnelled central venous catheters for incident haemodialysis patients: a Victorian survey exploring reasons for use Open
Background Tunnelled central venous catheters (T‐CVCs) are used globally as vascular access for patients on haemodialysis (HD) but are associated with increased sepsis, mortality, cost and length of hospitalisation compared with more perma…
View article: Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney Open
The anti-fibrotic effect of metformin has been widely demonstrated. Fibrosis in the kidney after injury is associated with reduced expression of genes involved in both fatty acid and glycolytic energy metabolism. We have previously reporte…
View article: Renal Recovery for Patients with ANCA-Associated Vasculitis and Low eGFR in the ADVOCATE Trial of Avacopan
Renal Recovery for Patients with ANCA-Associated Vasculitis and Low eGFR in the ADVOCATE Trial of Avacopan Open
View article: Supplementary Material for: Cardiac Output Changes during Renal Replacement Therapy: A Scoping Review
Supplementary Material for: Cardiac Output Changes during Renal Replacement Therapy: A Scoping Review Open
Introduction: Renal Replacement Therapy (RRT) is associated with hypotension. However, its impact on cardiac output (CO) is less understood. We aimed to describe current knowledge of CO monitoring and changes during RRT. Methods: We search…
View article: Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney Transplantation
Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney Transplantation Open
Background. Delayed graft function (DGF) is a major complication of deceased donor kidney transplantation. Saline (0.9% sodium chloride) is a commonly used intravenous fluid in transplantation but may increase the risk of DGF because of it…
View article: Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin
Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin Open
Severity of CI-AKI is exacerbated by the inability to regulate metabolism via phosphorylation of ACC. ACC phosphorylation contributes to the protective effect of metformin against AKI, influencing multiple mechanisms involved in the pathog…
View article: Lower versus higher starting tacrolimus dosing in kidney transplant recipients
Lower versus higher starting tacrolimus dosing in kidney transplant recipients Open
Achieving therapeutic tacrolimus levels is an essential component of balancing immunosuppression in kidney transplantation. At our institution, the starting tacrolimus dose was reduced from .075 mg/kg BD (higher dose [HD]) to .050 mg/kg BD…
View article: POS-733 SHARED DECISION-MAKING: MEASURING PATIENT EXPERIENCE FOR PATIENTS WITH END STAGE KIDNEY DISEASE (ESKD) STARTING DIALYSIS
POS-733 SHARED DECISION-MAKING: MEASURING PATIENT EXPERIENCE FOR PATIENTS WITH END STAGE KIDNEY DISEASE (ESKD) STARTING DIALYSIS Open
Patients with kidney failure face complex health care decisions. In this context, shared decision-making is recommended as a key principle of person-centred care. Person-centred care has been recognized as a strategic priority at local, st…
View article: Issue Information
Issue Information Open
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View article: Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis
Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis Open
View article: Study Protocol for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a pragmatic, registry-based, multi-center, double-blind, randomized controlled trial evaluating the effect of intravenous fluid therapy with Plasma-Lyte 148 versus 0.9% saline on delayed graft function in deceased donor kidney transplantation
Study Protocol for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a pragmatic, registry-based, multi-center, double-blind, randomized controlled trial evaluating the effect of intravenous fluid therapy with Plasma-Lyte 148 versus 0.9% saline on delayed graft function in deceased donor kidney transplantation Open
View article: Baseline characteristics of patients with atypical haemolytic uraemic syndrome (<scp>aHUS</scp>): The Australian cohort in a global <scp>aHUS</scp> registry
Baseline characteristics of patients with atypical haemolytic uraemic syndrome (<span>aHUS</span>): The Australian cohort in a global <span>aHUS</span> registry Open
Aims To describe the baseline characteristics and treatment of Australian patients diagnosed with atypical haemolytic uraemic syndrome (aHUS) reported to the Global aHUS Registry. Methods Descriptive analysis of the Australian cohort with …
View article: A tRial Evaluating Mid Cut-Off Value Membrane Clearance of Albumin and Light Chains in HemoDialysis Patients: A Safety Device Study
A tRial Evaluating Mid Cut-Off Value Membrane Clearance of Albumin and Light Chains in HemoDialysis Patients: A Safety Device Study Open
Background: A new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve the clearance of uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane clearance of A…
View article: The Symptom Monitoring with Feedback Trial (Swift) Study Protocol: An Anzdata Registry-Based Cluster Randomized Controlled Trial Among Australian and New Zealand Adults Receiving Haemodialysis for Kidney Failure
The Symptom Monitoring with Feedback Trial (Swift) Study Protocol: An Anzdata Registry-Based Cluster Randomized Controlled Trial Among Australian and New Zealand Adults Receiving Haemodialysis for Kidney Failure Open
View article: Risk factors for foot ulceration in adults with end-stage renal disease on dialysis: a prospective observational cohort study
Risk factors for foot ulceration in adults with end-stage renal disease on dialysis: a prospective observational cohort study Open
View article: SAT-078 OUTCOMES WITH LOWER VERSUS HIGHER STARTING TACROLIMUS DOSING IN KIDNEY TRANSPLANT RECIPIENTS
SAT-078 OUTCOMES WITH LOWER VERSUS HIGHER STARTING TACROLIMUS DOSING IN KIDNEY TRANSPLANT RECIPIENTS Open
The SYMPHONY study established low dose tacrolimus, mycophenolate, prednisolone and IL-2 receptor antagonist induction, as standard of care for immunosuppression in kidney transplant recipients (KTRs). In our service, we reduced the starti…
View article: SUN-068 RE-EVALUATION OF THE UTILITY OF BACK-UP ARTERIOVENOUS FISTULAS IN A CONTEMPORARY COHORT OF PERITONEAL DIALYSIS PATIENTS
SUN-068 RE-EVALUATION OF THE UTILITY OF BACK-UP ARTERIOVENOUS FISTULAS IN A CONTEMPORARY COHORT OF PERITONEAL DIALYSIS PATIENTS Open
The technique survival of peritoneal dialysis (PD) is limited, and transitions to haemodialysis (HD) are often unpredictable, due to events such as peritonitis or catheter malfunction. As such, there is a high risk of central venous cathet…
View article: SAT-048 IMPACT OF ANAESTHESIA ON PROSPECTIVE OUTCOMES AFTER THE CREATION OF ARTERIOVENOUS FISTULA
SAT-048 IMPACT OF ANAESTHESIA ON PROSPECTIVE OUTCOMES AFTER THE CREATION OF ARTERIOVENOUS FISTULA Open
The burden of patients requiring venous access to facilitate haemodialysis is well known. The preferred surgical access is the creation of a native arteriovenous fistula (AVF). However, these fistulae are known to have high early failure r…
View article: SUN-100 THE ASSOCIATION OF RESIDUAL KIDNEY FUNCTION WITH SYMPTOM BURDEN IN HAEMODIALYSIS PATIENTS
SUN-100 THE ASSOCIATION OF RESIDUAL KIDNEY FUNCTION WITH SYMPTOM BURDEN IN HAEMODIALYSIS PATIENTS Open
Residual kidney function (RKF) is associated with improved solute clearance, anaemia and phosphate control in haemodialysis (HD) patients. Patients with end stage kidney disease on HD experience a high symptom burden which impacts on quali…
View article: Absence of the β1 subunit of <scp>AMP</scp>‐activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes
Absence of the β1 subunit of <span>AMP</span>‐activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes Open
Summary Activation of the heterotrimeric energy‐sensing kinase AMP ‐activated protein kinase ( AMPK ) has been reported to improve experimental diabetic kidney disease. We examined the effect of type 1 diabetes in wild‐type ( WT ) mice and…
View article: Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia
Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia Open
View article: MOESM1 of Risk factors for foot ulceration in adults with end-stage renal disease on dialysis: a prospective observational cohort study
MOESM1 of Risk factors for foot ulceration in adults with end-stage renal disease on dialysis: a prospective observational cohort study Open
Additional file 1. Complete dataset of participant characteristics according to foot ulceration status at follow-up. Table showing the complete dataset of participant characteristics according to foot ulceration status at follow-up.
View article: Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles
Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles Open
Pre-eclampsia is a hypertensive disorder of pregnancy characterised by hypertension and sodium retention by the kidneys. To identify changes in sodium uptake proteins in the tubules of the distal nephron, we studied their expression in uri…