Peter Ferrazzano
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View article: Field evaluation of a wearable instrumented headband designed for measuring head kinematics
Field evaluation of a wearable instrumented headband designed for measuring head kinematics Open
Purpose: To study the relationship between soccer heading and the risk of mild traumatic brain injury (mTBI), we previously developed an instrumented headband and data processing scheme to measure the angular head kinematics of soccer head…
View article: P13 - Quality of life in patients with cystic thyroid nodules undergoing percutaneous ethanol injection: impact of treatment response after one year of follow-up
P13 - Quality of life in patients with cystic thyroid nodules undergoing percutaneous ethanol injection: impact of treatment response after one year of follow-up Open
Background/Introduction Little attention has been paid to the impact of percutaneous ethanol injection (PEI) of cystic thyroid nodules (CTNs) on health- related quality of life (HRQoL). Purpose To evaluate thyroid-related and generic HRQoL…
View article: Laboratory Evaluation of a Wearable Instrumented Headband for Rotational Head Kinematics Measurement
Laboratory Evaluation of a Wearable Instrumented Headband for Rotational Head Kinematics Measurement Open
Purpose Mild traumatic brain injuries (mTBI) are a highly prevalent condition with heterogeneous outcomes between individuals. A key factor governing brain tissue deformation and the risk of mTBI is the rotational kinematics of the head. I…
View article: Correction: Thymic hyperplasia is accurate to detect new-onset Graves’ hyperthyroidism and resolves after restoring euthyroidism
Correction: Thymic hyperplasia is accurate to detect new-onset Graves’ hyperthyroidism and resolves after restoring euthyroidism Open
View article: Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury
Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury Open
Introduction 7,8-Dihydroxyflavone (7,8-DHF) is a promising translational therapy in several brain injury models, including the neonatal hypoxia-ischemia (HI) model in mice. However, the neuroprotective effect of 7,8-DHF was only observed i…
View article: Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity
Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity Open
Importance: Neurological manifestations during acute SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C) are common in hospitalized patients younger than 18 years and may increase risk of new neurocognitive or function…
View article: MRI and Clinical Variables for Prediction of Outcomes After Pediatric Severe Traumatic Brain Injury
MRI and Clinical Variables for Prediction of Outcomes After Pediatric Severe Traumatic Brain Injury Open
Importance Traumatic brain injury (TBI) is a leading cause of death and disability in children, and predicting functional outcome after TBI is challenging. Magnetic resonance imaging (MRI) is frequently conducted after severe TBI; however,…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuroprotection strategies in the neonate
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuroprotection strategies in the neonate Open
BACKGROUND: Cerebral intraventricular hemorrhage (IVH) is a major cause of neurodevelopmental impairment in preterm infants.IVH is characterized by vessel rupture and a rapid accumulation of blood within the ventricles.Subsequent hemolysis…
View article: Corrigendum: Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C
Corrigendum: Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C Open
[This corrects the article DOI: 10.3389/fped.2024.1340385.].
View article: Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity
Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity Open
Importance Neurological manifestations during acute SARS-CoV-2–related multisystem inflammatory syndrome in children (MIS-C) are common in hospitalized patients younger than 18 years and may increase risk of new neurocognitive or functiona…
View article: TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury Open
Background Neonatal hypoxia ischemia (HI) related brain injury is one of the major causes of learning disabilities and memory deficits in children. In both human and animal studies, female neonate brains are less susceptible to HI than mal…
View article: Thymic hyperplasia is accurate to detect new-onset Graves’ hyperthyroidism and resolves after restoring euthyroidism
Thymic hyperplasia is accurate to detect new-onset Graves’ hyperthyroidism and resolves after restoring euthyroidism Open
View article: Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C
Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C Open
Introduction Hospitalized children diagnosed with SARS-CoV-2-related conditions are at risk for new or persistent symptoms and functional impairments. Our objective was to analyze post-hospital symptoms, healthcare utilization, and outcome…
View article: TrkB-mediated sustained neuroprotection is sex-specific and $$\text{ER}\alpha$$-dependent in adult mice following neonatal hypoxia ischemia
TrkB-mediated sustained neuroprotection is sex-specific and $$\text{ER}\alpha$$-dependent in adult mice following neonatal hypoxia ischemia Open
View article: Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBI
Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBI Open
This investigation explores memory performance using the California Verbal Learning Test in relation to morphometric and connectivity measures of the memory network in severe traumatic brain injury. Twenty-two adolescents with severe traum…
View article: Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C
Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C Open
View article: Selectively compromised inner retina function following hypoxic-ischemic encephalopathy in mice: A noninvasive measure of severity of the injury
Selectively compromised inner retina function following hypoxic-ischemic encephalopathy in mice: A noninvasive measure of severity of the injury Open
View article: Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma
Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma Open
Young children with severe traumatic brain injury (TBI) have frequently been excluded from studies due to age and/or mechanism of injury. Magnetic resonance imaging (MRI) is now frequently being utilized to detect parenchymal injuries and …
View article: A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care
A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care Open
Pediatric neurocritical care (PNCC) is a rapidly growing field. Challenges posed by the COVID-19 pandemic on trainee exposure to educational opportunities involving direct patient care led to the creative solutions for virtual education su…
View article: Mahalanobis distance tractometry (MaD-Tract) – a framework for personalized white matter anomaly detection applied to TBI
Mahalanobis distance tractometry (MaD-Tract) – a framework for personalized white matter anomaly detection applied to TBI Open
Imaging-based quantitative measures from diffusion-weighted MRI (dMRI) offer the ability to non-invasively extract microscopic information from human brain tissues. Group-level comparisons of such measures represent an important approach t…
View article: Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury
Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury Open
In this comparative effectiveness study, CSF diversion was not associated with improved outcome at 6 months after TBI, but a decrease in ICP was observed. Given the higher quality of evidence generated by this study, current evidence-based…
View article: Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury
Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury Open
In this comparative effectiveness research study, bolus HTS was associated with lower ICP and higher CPP, whereas mannitol was associated only with higher CPP. After adjustment for confounders, both therapies showed no association with ICP…
View article: Novel Injury Scoring Tool for Assessing Brain Injury following Neonatal Hypoxia-Ischemia in Mice
Novel Injury Scoring Tool for Assessing Brain Injury following Neonatal Hypoxia-Ischemia in Mice Open
The variability of severity in hypoxia-ischemia (HI)-induced brain injury among research subjects is a major challenge in developmental brain injury research. Our laboratory developed a novel injury scoring tool based on our gross patholog…
View article: Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C
Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C Open
View article: A Survey of Neuromonitoring Practices in North American Pediatric Intensive Care Units
A Survey of Neuromonitoring Practices in North American Pediatric Intensive Care Units Open
View article: Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents
Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents Open
Adolescent traumatic brain injury (TBI) is a major public health concern, resulting in >35,000 hospitalizations in the United States each year. Although neuroimaging is a primary diagnostic tool in the clinical assessment of TBI, our under…
View article: A 3D Fully Convolutional Neural Network With Top-Down Attention-Guided Refinement for Accurate and Robust Automatic Segmentation of Amygdala and Its Subnuclei
A 3D Fully Convolutional Neural Network With Top-Down Attention-Guided Refinement for Accurate and Robust Automatic Segmentation of Amygdala and Its Subnuclei Open
Recent advances in deep learning have improved the segmentation accuracy of subcortical brain structures, which would be useful in neuroimaging studies of many neurological disorders. However, most existing deep learning based approaches i…
View article: Accurate Automatic Segmentation of Amygdala Subnuclei and Modeling of Uncertainty via Bayesian Fully Convolutional Neural Network
Accurate Automatic Segmentation of Amygdala Subnuclei and Modeling of Uncertainty via Bayesian Fully Convolutional Neural Network Open
Recent advances in deep learning have improved the segmentation accuracy of subcortical brain structures, which would be useful in neuroimaging studies of many neurological disorders. However, most of the previous deep learning work does n…
View article: Developmental differences in microglia morphology and gene expression during normal brain development and in response to hypoxia-ischemia
Developmental differences in microglia morphology and gene expression during normal brain development and in response to hypoxia-ischemia Open
View article: A - 59Comorbidities and Sequelae for Mild Traumatic Brain Injury in a Clinical Population
A - 59Comorbidities and Sequelae for Mild Traumatic Brain Injury in a Clinical Population Open