Jason P. Fine
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View article: Mobile crisis effectiveness: a systematic review and associated functions and forms framework
Mobile crisis effectiveness: a systematic review and associated functions and forms framework Open
The limited evidence uncovered in this review offers tentative support for MCU effectiveness. However, the current literature is too sparse to draw firm or generalized conclusions. An initial theoretical framework was created to help pract…
View article: Interpathologist Diagnostic Agreement for Non–Small Cell Lung Carcinomas Using Current and Recent Classifications
Interpathologist Diagnostic Agreement for Non–Small Cell Lung Carcinomas Using Current and Recent Classifications Open
CONTEXT.—: Measurement of interpathologist diagnostic agreement (IPDA) should allow pathologists to improve current diagnostic criteria and disease classifications. OBJECTIVES.—: To determine how IPDA for pathologists' diagnoses of non-sma…
View article: Inverse Probability of Treatment Weighting Using the Propensity Score With Competing Risks in Survival Analysis
Inverse Probability of Treatment Weighting Using the Propensity Score With Competing Risks in Survival Analysis Open
Inverse probability of treatment weighting (IPTW) using the propensity score allows estimation of the effect of treatment in observational studies. We had three objectives: first, to describe methods for using IPTW to estimate the effects …
View article: P1205 Long-term treatment patterns, dose escalation, and steroid use among patients with moderate-to-severe ulcerative colitis using advanced therapies: >3 years of continuous follow up using IQVIA PharMetrics Plus database
P1205 Long-term treatment patterns, dose escalation, and steroid use among patients with moderate-to-severe ulcerative colitis using advanced therapies: >3 years of continuous follow up using IQVIA PharMetrics Plus database Open
Background Induction and/or maintenance of remission is seen in less than half of ulcerative colitis (UC) patients with advanced therapies (AT).1,2 This results in frequent switching, dose-optimization, and steroid use to maintain disease …
View article: On GEE for Mean‐Variance‐Correlation Models: Variance Estimation and Model Selection
On GEE for Mean‐Variance‐Correlation Models: Variance Estimation and Model Selection Open
Generalized estimating equations (GEE) are of great importance in analyzing clustered data without full specification of multivariate distributions. A recent approach by Luo and Pan jointly models the mean, variance, and correlation coeffi…
View article: Pooling controls from nested case–control studies with the proportional risks model
Pooling controls from nested case–control studies with the proportional risks model Open
The standard approach to regression modeling for cause-specific hazards with prospective competing risks data specifies separate models for each failure type. An alternative proposed by Lunn and McNeil (1995) assumes the cause-specific haz…
View article: Nonparametric binary instrumental variable analysis of competing risks data
Nonparametric binary instrumental variable analysis of competing risks data Open
In both observational studies and randomized trials with noncompliance, unmeasured confounding may exist which may bias treatment effect estimates. Instrumental variables (IV) are a popular technique for addressing such confounding, enabli…
View article: Infant gut microbiome composition is associated with non-social fear behavior in a pilot study
Infant gut microbiome composition is associated with non-social fear behavior in a pilot study Open
Experimental manipulation of gut microbes in animal models alters fear behavior and relevant neurocircuitry. In humans, the first year of life is a key period for brain development, the emergence of fearfulness, and the establishment of th…
View article: The Influence of Screening, Misclassification, and Reporting Biases on Reported Chlamydia Case Rates among Young Women in the United States, 2000 through 2017
The Influence of Screening, Misclassification, and Reporting Biases on Reported Chlamydia Case Rates among Young Women in the United States, 2000 through 2017 Open
Background National chlamydia case rate trends are difficult to interpret because of biases from partial screening coverage, imperfect diagnostic tests, and underreporting. We examined the extent to which these time-varying biases could in…
View article: On GEE for Mean-Variance-Correlation Models: Variance Estimation and Model Selection
On GEE for Mean-Variance-Correlation Models: Variance Estimation and Model Selection Open
Generalized estimating equations (GEE) are of great importance in analyzing clustered data without full specification of multivariate distributions. A recent approach jointly models the mean, variance, and correlation coefficients of clust…
View article: G‐estimation of structural nested mean models for interval‐censored data using pseudo‐observations
G‐estimation of structural nested mean models for interval‐censored data using pseudo‐observations Open
Two large‐scale randomized clinical trials compared fenofibrate and placebo in diabetic patients with pre‐existing retinopathy (FIELD study) or risk factors (ACCORD trial) on an intention‐to‐treat basis and reported a significant reduction…
View article: Regression analysis of longitudinal data with mixed synchronous and asynchronous longitudinal covariates
Regression analysis of longitudinal data with mixed synchronous and asynchronous longitudinal covariates Open
In linear models, omitting a covariate that is orthogonal to covariates in the model does not result in biased coefficient estimation. This in general does not hold for longitudinal data, where additional assumptions are needed to get unbi…
View article: Inference on subgroups identified based on a heterogeneous treatment effect in a post hoc analysis of a clinical trial
Inference on subgroups identified based on a heterogeneous treatment effect in a post hoc analysis of a clinical trial Open
Due to the many benefits of understanding treatment effect heterogeneity in a clinical trial, an exploratory post hoc subgroup analysis is often performed to find subpopulations of patients with conditional average treatment effect that su…
View article: Effects of anesthesia exposure on postnatal maturation of white matter in rhesus monkeys
Effects of anesthesia exposure on postnatal maturation of white matter in rhesus monkeys Open
There is increasing concern about the potential effects of anesthesia exposure on the developing brain. The effects of relatively brief anesthesia exposures used repeatedly to acquire serial magnetic resonance imaging scans could be examin…
View article: An imputation approach for a time-to-event analysis subject to missing outcomes due to noncoverage in disease registries
An imputation approach for a time-to-event analysis subject to missing outcomes due to noncoverage in disease registries Open
Summary Disease incidence data in a national-based cohort study would ideally be obtained through a national disease registry. Unfortunately, no such registry currently exists in the United States. Instead, the results from individual stat…
View article: Semiparametric analysis of a generalized linear model with multiple covariates subject to detection limits
Semiparametric analysis of a generalized linear model with multiple covariates subject to detection limits Open
Studies on the health effects of environmental mixtures face the challenge of limit of detection (LOD) in multiple correlated exposure measurements. Conventional approaches to deal with covariates subject to LOD, including complete‐case an…
View article: A parametric approach to relaxing the independence assumption in relative survival analysis
A parametric approach to relaxing the independence assumption in relative survival analysis Open
With known cause of death (CoD), competing risk survival methods are applicable in estimating disease-specific survival. Relative survival analysis may be used to estimate disease-specific survival when cause of death is either unknown or …
View article: Accounting for Preinvasive Conditions in Analysis of Invasive Cancer Risk: Application to Breast Cancer.
Accounting for Preinvasive Conditions in Analysis of Invasive Cancer Risk: Application to Breast Cancer. Open
When estimating invasive cancer risk while preinvasive conditions are actively treated, it is important to consider the implied assumptions and potential biases of conventional approaches. Although still not perfect, we proposed two practi…
View article: A Parametric Approach to Relaxing the Independence Assumption in Relative Survival Analysis
A Parametric Approach to Relaxing the Independence Assumption in Relative Survival Analysis Open
With known cause of death (CoD), competing risk survival methods are applicable in estimating disease-specific survival. Relative survival analysis may be used to estimate disease-specific survival when cause of death is either unknown or …
View article: Estimation of Causal Quantile Effects with a Binary Instrumental Variable and Censored Data
Estimation of Causal Quantile Effects with a Binary Instrumental Variable and Censored Data Open
The causal effect of a treatment is of fundamental interest in the social, biological and health sciences. Instrumental variable (IV) methods are commonly used to determine causal treatment effects in the presence of unmeasured confounding…
View article: Semiparametric estimation of the proportional rates model for recurrent events data with missing event category
Semiparametric estimation of the proportional rates model for recurrent events data with missing event category Open
Proportional rates models are frequently used for the analysis of recurrent event data with multiple event categories. When some of the event categories are missing, a conventional approach is to either exclude the missing data for a compl…
View article: Infant gut microbiome composition is associated with non-social fear behavior in a pilot study
Infant gut microbiome composition is associated with non-social fear behavior in a pilot study Open
Experimental manipulation of gut microbes in animal models alters fear behavior and relevant neurocircuitry. In humans, the first year of life is a key period for brain development, the emergence of fearfulness, and the establishment of th…
View article: Host Genetic Risk Factors for <i>Chlamydia trachomatis</i>-Related Infertility in Women
Host Genetic Risk Factors for <i>Chlamydia trachomatis</i>-Related Infertility in Women Open
Background Chlamydia trachomatis (Ct) infection ascending to the upper genital tract can cause infertility. Direct association of genetic variants as contributors is challenging because infertility may not be diagnosed until years after in…