Peter Fuchs
YOU?
Author Swipe
View article: Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-γ in ex vivo skin cultures
Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-γ in ex vivo skin cultures Open
Proteins of the plakin family are predominantly expressed in the epidermis and play a crucial role in cytoskeletal assembly by crosslinking intracellular structural components with cell–cell junctions and the plasma membrane. While most pl…
View article: Retinal regions shape human and murine Müller cell proteome profile and functionality
Retinal regions shape human and murine Müller cell proteome profile and functionality Open
The human macula is a highly specialized retinal region with pit‐like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We compared prot…
View article: A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics
A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics Open
Keratins exert important structural but also cytoprotective functions. They have to be adaptable to support cellular homeostasis. Epiplakin (EPPK1) has been shown to decorate keratin filaments in epithelial cells and to play a protective r…
View article: The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo Open
Inhibition of the interaction between the scaffolding protein PSD-95 and the NMDA receptor has been shown to obstruct ischemic stroke-triggered excitotoxic reactions, leading to neuronal death. The peptides NR2B9c and N -dimer are inhibito…
View article: Comparative genomics reveals evolutionary loss of epiplakin in cetaceans
Comparative genomics reveals evolutionary loss of epiplakin in cetaceans Open
The adaptation of vertebrates to different environments was associated with changes in the molecular composition and regulation of epithelia. Whales and dolphins, together forming the clade cetaceans, have lost multiple epithelial keratins…
View article: Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis
Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis Open
Loss of Oct3 leads to enhanced proliferation and hepatocarcinogenesis in vivo.