Peter G. Gibson
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View article: Treatable Traits. Why, What, How?
Treatable Traits. Why, What, How? Open
Chronic airway diseases, such as asthma, bronchiectasis and chronic obstructive pulmonary disease (COPD), are complex and heterogeneous conditions. Hence, their assessment and management need to be personalized and precise. A decade ago, a…
View article: Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry
Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition often associated with type 2 inflammation. While biologics are a promising treatment for patients with uncontrolled CRSwNP, real-world evid…
View article: Letter: Gas‐Sensing Capsules Advance Colonic Physiology Research Toward Clinical Translation. Authors' Reply
Letter: Gas‐Sensing Capsules Advance Colonic Physiology Research Toward Clinical Translation. Authors' Reply Open
View article: Letter on ‘Telemetric Assessment and Comparison of Regional Colonic Metabolic Activity in Ambulant Healthy Individuals Using <scp>pH</scp> and Gas‐Sensing Wireless Motility Capsules’: Authors' Reply
Letter on ‘Telemetric Assessment and Comparison of Regional Colonic Metabolic Activity in Ambulant Healthy Individuals Using <span>pH</span> and Gas‐Sensing Wireless Motility Capsules’: Authors' Reply Open
View article: Clinical remission in severe asthma treated with biologics and macrolides: Definition, prevalence, associated factors, and future perspectives
Clinical remission in severe asthma treated with biologics and macrolides: Definition, prevalence, associated factors, and future perspectives Open
View article: Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i>
Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i> Open
International audience
View article: Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes
Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes Open
Background In utero mechanisms related to oxidative stress response, inflammation, and extracellular matrix turnover may influence fetal lung development in the offspring of asthmatic mothers. Therefore, we aimed to determine whether level…
View article: Key priorities to prevent avoidable asthma hospitalisations: insights from end-users
Key priorities to prevent avoidable asthma hospitalisations: insights from end-users Open
Preventable asthma hospitalisations remain a major concern. Guided by end-user input, this study identifies 9 research priorities to help Asthma Australia halve hospitalisations by 2030 and improve life for people with asthma and their fam…
View article: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach
Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach Open
T2-targeting biologics have utility in the management of asthma with low T2 involvement, but more effective therapies are needed. Further research is warranted to identify specific pathogenic pathways at the lower end of the T2 spectrum th…
View article: The value of treatable traits across the spectrum of adult asthma severity
The value of treatable traits across the spectrum of adult asthma severity Open
Asthma is a heterogeneous condition characterized by diverse clinical phenotypes and variable treatment responses, underscoring the limitations of the traditional "one-size-fits-all" stepwise management paradigm. The treatable traits (TTs)…
View article: Safety of the 6-min walk test in adults with severe asthma
Safety of the 6-min walk test in adults with severe asthma Open
The 6MWT is safe for adults with severe asthma when pre-bronchodilation is provided and SpO2 <85 % is used as a stopping criterion. Participants treated or not with mAb achieved comparable 6MWT distances.
View article: Evaluation of the effect of multimorbidity on difficult-to-treat asthma using a novel score (MiDAS): a multinational study of asthma cohorts
Evaluation of the effect of multimorbidity on difficult-to-treat asthma using a novel score (MiDAS): a multinational study of asthma cohorts Open
UK National Institute for Health and Care Research, Australian National Health and Medical Research Council, Hunter Medical Research Institute, University of Newcastle (Australia), and John Hunter Hospital Charitable Trust.
View article: Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)
Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR) Open
View article: Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion
Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion Open
Treatment targets in severe asthma have evolved towards a remission‐focused paradigm guided by precision medicine. This novel concept requires a shift from evaluating the efficacy of therapies based on a single outcome at a single time poi…
View article: Prediction Pathway for Severe Asthma Exacerbations
Prediction Pathway for Severe Asthma Exacerbations Open
This study identified an essential prediction pathway of severe exacerbation, which involves the influence of chronic rhinosinusitis on the immediate predictors of risk transition from current to future severe asthma exacerbations. Macroli…
View article: A Global Achievement: Introducing the Inducible Laryngeal Dysfunction/Vocal Cord Dysfunction Toolkit—A Free Global, Peer‐Reviewed Clinical Resource
A Global Achievement: Introducing the Inducible Laryngeal Dysfunction/Vocal Cord Dysfunction Toolkit—A Free Global, Peer‐Reviewed Clinical Resource Open
View article: Engagement and outcomes of virtual antenatal asthma care: a randomised controlled tele-trial
Engagement and outcomes of virtual antenatal asthma care: a randomised controlled tele-trial Open
Background Access, availability and engagement of optimal asthma management are limited in maternity care. This study evaluated the engagement and outcomes of a virtual model of antenatal asthma care compared to a face-to-face model. Metho…
View article: Digitally mapping the asthma journey—from diagnosis to remission
Digitally mapping the asthma journey—from diagnosis to remission Open
None.
View article: Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data
Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data Open
Biologic initiation in patients with SA led to substantial reduction in TOCS exposure, particularly in the first year. Future analyses will explore the impact on OCS-related adverse health events.
View article: Circulating Mast Cell Progenitors Are Depleted by Benralizumab in Severe Asthma
Circulating Mast Cell Progenitors Are Depleted by Benralizumab in Severe Asthma Open
View article: Breastfeeding outcomes and maternal asthma in the early postpartum period: an Australian population-based obstetric records analysis
Breastfeeding outcomes and maternal asthma in the early postpartum period: an Australian population-based obstetric records analysis Open
Maternal asthma increases the risk of adverse perinatal and respiratory outcomes in their infants (1) ; breastfeeding may mitigate the risk of respiratory outcomes, including wheeze (2,3) . However, breastfeeding rates are lower in women w…
View article: Dysfunctional Breathing and Depression Are Core Extrapulmonary and Behavior/Risk Factor Traits in Type 2–High Severe Asthma
Dysfunctional Breathing and Depression Are Core Extrapulmonary and Behavior/Risk Factor Traits in Type 2–High Severe Asthma Open
Core extrapulmonary and behavior/risk factor traits in T2-high severe asthma were dysfunctional breathing and depression, contributing to worse asthma outcomes, suggesting that core TTs may differ between asthma inflammatory phenotypes. El…
View article: Treatable Trait Guided Asthma Management: A Feasibility Study
Treatable Trait Guided Asthma Management: A Feasibility Study Open
Background and Objectives Treatable trait‐based personalised medicine improves outcomes in severe asthma clinics. We assessed the feasibility of a randomised controlled trial (RCT) of protocolised treatable trait‐guided asthma management i…
View article: My Lungs Have Feelings Too!
My Lungs Have Feelings Too! Open
View article: What are the broader impacts and value from a randomised controlled trial conducted in six public hospital antenatal clinics in Australia? An impact assessment using the Framework to Assess the Impact from Translational health research
What are the broader impacts and value from a randomised controlled trial conducted in six public hospital antenatal clinics in Australia? An impact assessment using the Framework to Assess the Impact from Translational health research Open
Objectives The Breathing for Life Trial (BLT) was a multicentre randomised controlled trial testing the hypothesis that a fractional exhaled nitric oxide-based intervention to guide asthma therapy in pregnancy improves perinatal outcomes. …
View article: Infant respiratory outcomes following asthma management and exacerbations in pregnancy
Infant respiratory outcomes following asthma management and exacerbations in pregnancy Open
Background Improved maternal asthma management in pregnancy may reduce recurrent bronchiolitis and wheeze outcomes in infancy. We assessed whether infant bronchiolitis and wheeze outcomes are influenced by inflammation-guided management in…
View article: International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update
International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update Open
The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As the first global registry for adults with severe asthma,…
View article: Approaches in landscape fire smoke pregnancy research and the impact on offspring: A review of knowledge gaps and recommendations
Approaches in landscape fire smoke pregnancy research and the impact on offspring: A review of knowledge gaps and recommendations Open
The increase in wildfires and bushfires due to climate change means that more people, including pregnant women and their fetuses will be exposed to landscape fire smoke. Although there is evidence to suggest that pregnancy landscape fire e…
View article: Perceptions of sedentary behaviour in people with severe asthma: a qualitative study
Perceptions of sedentary behaviour in people with severe asthma: a qualitative study Open
People with severe asthma often lead sedentary lifestyles, which adversely affects overall health and asthma-specific outcomes. To inform future sedentary behaviour- interventions, this study aimed to explore perceptions of sedentary behav…
View article: Run-in periods and treatment outcomes in asthma trials: A narrative review
Run-in periods and treatment outcomes in asthma trials: A narrative review Open
We discuss the potential implications associated with the various trial designs, and propose that run-in periods should be consciously designed to meet the goals of the specific study. We also propose that standardized reporting of run-in …