Explanipedia

Patient-reported outcomes, neurocognitive functioning and oncologic results of pencil-beam-scanning proton beam therapy for CNS WHO G2 and G3 IDH1-mutant diffuse adult glioma: A single institution experience Open

Maciej Pelak, Allan Hummer, Prof Eugen Hug, Sebastian Töpfer, Ing Birgit Flechl , et al. · 2025

Proton therapy is a safe and effective treatment for IDH1/2-mutant diffuse glioma with no apparent detrimental effect on QoL and neurocognitive functioning in this prospective cohort.

Steroid Withdrawal Versus Maintenance in Simultaneous Pancreas–Kidney Transplantation: Long‐Term Outcomes in a Single‐Center Retrospective Cohort Open

Raphaël Meier, Ali B. Abbasi, Gerardo Gamino, Yvonne Kelly, Mehdi Tavakol , et al. · 2025

Background Simultaneous pancreas and kidney (SPK) transplants using steroid‐free regimens are a frequently used immunosuppressive strategy in low immunologic risk recipients. The long‐term effect on recipient outcomes remains incompletely …

The potential of kidney transplantation to reduce mortality from chronic kidney disease: a global, cross-sectional, modelling study Open

Alan Zambeli-Ljepović, Somkanya Tungsanga, Anukul Ghimire, Aminu K. Bello, Ikechi G. Okpechi , et al. · 2025

None.

Left Ventricular Ejection Fraction and Previous Cardiac Revascularization: Impact on Patient Survival, Graft Survival, and Complications in Kidney Transplant Recipients Open

Dominic Amara, Miguel de Burgos Núñez, Justin Parekh, Stuart Greenstein, David P. Foley , et al. · 2025

Background. Kidney transplant physicians believe that the cardiac status of kidney transplant recipients influences posttransplant outcomes. However, the Scientific Registry of Transplant Recipients (SRTR) does not include cardiac variable…

Kaposi Sarcoma–Associated Herpesvirus Risk and Disease in Kidney Donors and Transplant Recipients With Human Immunodeficiency Virus in the United States Open

Puja H. Nambiar, Tao Liang, Nazzarena Labò, Jonathan Hand, Emily A. Blumberg , et al. · 2025

Background Due to high prevalence of Kaposi sarcoma–associated herpesvirus (KSHV) among people with human immunodeficiency virus (HIV), KSHV-associated disease (KAD) may be increased after kidney transplantation from donors with HIV (HIV D…

<i>APOL1</i> genotype and patient outcomes in US and South African transplant recipients with HIV who received kidneys from donors with HIV Open

Robert Freercks, Moreno Magalhães de Souza Rodrigues, Kathryn Manning, Jurgen Heymann, Jeffrey B. Kopp , et al. · 2025

Importance Lower kidney allograft survival has been demonstrated in kidney transplant recipients (KTR) without HIV whose donors have two apolipoprotein L1 ( APOL1 ) renal risk variants (RRV). The effects of APOL1 RRV on kidney transplant o…

Safety of Kidney Transplantation from Donors with HIV Open

Christine M. Durand, Allan B. Massie, Sander Florman, Tao Liang, Meenakshi Rana , et al. · 2024

The primary objective of this study is to determine if an HIV-infected deceased kidney donor (HIVD+) transplant is safe with regard to major transplant-related and HIV-related complications.

Consent for High–Kidney Donor Profile Index Kidneys Open

Peter G. Stock, Charles G. Rickert · 2024

Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, California Correspondence: Dr. Peter Stock, email: [email protected] See related article, "Quantifying the Effect of Consent for …

Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act Open

Jennifer D. Motter, Sarah Hussain, Diane Brown, Sander Florman, Meenakshi Rana , et al. · 2023

Background. Kidney transplant (KT) candidates with HIV face higher mortality on the waitlist compared with candidates without HIV. Because the HIV Organ Policy Equity (HOPE) Act has expanded the donor pool to allow donors with HIV (D + ), …

410.8: Improving the safety of stem-cell-derived beta cell transplantation with an inducible safety switch Open

Simon N. Chu, Nur Shabrina Amirruddin, Devesh Sharma, Isabel Sierra, Peter G. Stock , et al. · 2023

Introduction: In patients with type 1 diabetes mellitus, glucose homeostasis can be re-established with allogeneic islet transplantation. This approach has the advantage of overcoming the surgical morbidity of whole pancreas transplant. Ho…

Living kidney donors with HIV: experience and outcomes from a case series by the HOPE in Action Consortium Open

Christine M. Durand, Nina Martinez, Karl Neumann, Reed C. Benedict, Arthur W. Baker , et al. · 2023

National Institute of Allergy and Infectious Diseases, National Institutes of Health.

A Multi-Modal Approach to Islet and Pancreas Transplantation With Calcineurin-Sparing Immunosuppression Maintains Long-Term Insulin Independence in Patients With Type I Diabetes Open

Steven A. Wisel, Andrew M. Posselt, Gregory L. Szot, Miguel Nunez, Keli S. Santos-Parker , et al. · 2023

Long-term success in beta-cell replacement remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta-cells and renal function. We report a multi-modal approach including islet and pancreas-after-islet (PAI) transplant ut…

Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry Open

Mikaël Chetboun, Élodie Drumez, Cassandra Ballou, Mehdi Maanaoui, Elizabeth H. Payne , et al. · 2023

COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort Open

Garrett R. Roll, Robert A. Bray, Matthew Cooper, Todd N. Eagar, Howard M. Gebel , et al. · 2023

OPTN/SRTR 2021 Annual Data Report: Pancreas Open

Raja Kandaswamy, Peter G. Stock, Jonathan M. Miller, Joann White, Sarah E. Booker , et al. · 2023

The John S. Najarian symposium: The past, present, and future of surgery and transplantation, May 20, 2022, Minneapolis, MN Open

Mary E. Knatterud, Richard L. Simmons, William D. Payne, Peter G. Stock, Blanche M. Chavers , et al. · 2022

Dr John S Najarian (1927–2020), chairman of the Department of Surgery at the University of Minnesota from 1967 to 1993, was a pioneer in surgery, clinical immunology and transplantation. A Covid‐delayed Festschrift was held in his honor on…

The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir Open

Sarah E. Benner, Yolanda Eby, Xianming Zhu, Reinaldo E. Fernández, Eshan U. Patel , et al. · 2022

The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evalua…

Long-term Outcomes With Islet-Alone and Islet-After-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: The CIT-08 Study Open

Michael R. Rickels, Thomas L. Eggerman, Levent Bayman, Julie C. Qidwai, Rodolfo Alejandro , et al. · 2022

OBJECTIVE To determine long-term outcomes for islet-alone and islet-after-kidney transplantation in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia. RESEARCH DESIGN AND METHODS This was a prospective intervent…

Erratum Open

Raja Kandaswamy, Peter G. Stock, Jonathan Miller, Jonathan White, S.E. Booker , et al. · 2022

Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome Open

Allison J. Kwong, W. Ray Kim, John R. Lake, Peter G. Stock, Connie J. Wang , et al. · 2022

Background. The Scientific Registry of Transplant Recipients (SRTR) had not traditionally considered biopsy results in risk-adjustment models, yet biopsy results may influence outcomes and thus decisions regarding organ acceptance. Methods…

A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation Open

Thierry Berney, Axel Andrès, Melena D. Bellin, Eelco J.P. de Koning, Paul Johnson , et al. · 2022

A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000–2020 period, including impact on activity of …

Effects of Multi-stage Procurement on the Viability and Function of Human Donor Parathyroid Glands Open

Yvonne Kelly, Casey Ward, Run Zhang, Shareef M. Syed, Peter G. Stock , et al. · 2022

Parathyroid tissue retains viability, calcium-sensing capacity, and in vivo engraftment capability after en bloc cadaveric resection, ex vivo dissection, and extended cold storage.

Procurement of Deceased Donor Parathyroid Glands With the Aid of Near-infrared Autofluorescence Imaging Open

Casey Ward, Yvonne Kelly, Shareef M. Syed, Raphaël Meier, Tadasuke Ando , et al. · 2022

Background. Parathyroid allotransplantation is a burgeoning treatment for severe hypoparathyroidism. Deceased donor parathyroid gland (PTG) procurement can be technically challenging due to lack of normal intraoperative landmarks and expos…

International Survey of Clinical Monitoring Practices in Pancreas and Islet Transplantation Open

Casey Ward, Jon S. Odorico, Michael R. Rickels, Thierry Berney, George W. Burke , et al. · 2022

Background. The long-term outcomes of both pancreas and islet allotransplantation have been compromised by difficulties in the detection of early graft dysfunction at a time when a clinical intervention can prevent further deterioration an…

Long-term Outcomes Following Kidney and Liver Transplant in Recipients With HIV Open

Arya Zarinsefat, Arushi Gulati, Amy Shui, Hillary J. Braun, Rodney Rogers , et al. · 2022

In this single-center cohort study, KT and LT in HIV-positive patients had comparable long-term outcomes with those in matched HIV-negative patients. The high incidence of acute rejection was associated with reduced graft survival. The fin…

Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation Open

Raphaël Meier, Yvonne Kelly, Seiji Yamaguchi, Hillary J. Braun, Tyler Lunow-Luke , et al. · 2022

Background: Scoring systems have been proposed to select donation after circulatory death (DCD) donors and recipients for liver transplantation (LT). We hypothesized that complex scoring systems derived in large datasets might not predict …

COVID-19 Vaccination in Kidney Transplant Recipients: An Ounce Pre-Transplant is Worth a Pound Post-Transplant Open

Sindhu Chandran, Peter G. Stock · 2021

The Coronavirus Disease 2019 (COVID-19) Vaccine FAQ sheet on the American Society of Transplantation (AST) website relays information on the current state of knowledge to transplant professionals and the community regarding the COVID-19 va…

HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV Open

Christine M. Durand, Sander Florman, Jennifer D. Motter, Diane Brown, Darin Ostrander , et al. · 2021

Ethical review of COVID-19 vaccination requirements for transplant center staff and patients Open

Olivia S. Kates, Peter G. Stock, Michael G. Ison, Richard D. Allen, Patrizia Burra , et al. · 2021

National Landscape of Human Immunodeficiency Virus–Positive Deceased Organ Donors in the United States Open

William A. Werbel, Diane Brown, Oyinkansola Kusemiju, Brianna Doby, Shanti Seaman , et al. · 2021

Background Organ transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV-p…

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