Thomas Meyer
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View article: Patients with anorexia nervosa perceive higher emotional connectedness to their parents than bulimia nervosa patients independent of objective family factors
Patients with anorexia nervosa perceive higher emotional connectedness to their parents than bulimia nervosa patients independent of objective family factors Open
Summary Background Psychological constructs of individual autonomy (IA) and emotional connectedness (EC) differ between patients with anorexia nervosa (AN) and bulimia nervosa (BN); however, it is unclear whether objective family factors m…
View article: Psychopathological symptom severity and parent–child age differences in patients with eating disorders
Psychopathological symptom severity and parent–child age differences in patients with eating disorders Open
Summary Background Although family factors affecting the development of eating disorders (EDs) have been extensively studied, it is unknown whether the age gaps between the parents and their affected child have an impact on the overall psy…
View article: N-terminal truncation of STAT1 transcription factor causes CD3- and CD20-negative non-Hodgkin lymphoma through upregulation of STAT3-mediated oncogenic functions
N-terminal truncation of STAT1 transcription factor causes CD3- and CD20-negative non-Hodgkin lymphoma through upregulation of STAT3-mediated oncogenic functions Open
View article: Modifiable unhealthy lifestyle behaviours in subclinical manifestations of attention-deficit hyperactivity disorder: what are the first empirical results and putative clinical implications?
Modifiable unhealthy lifestyle behaviours in subclinical manifestations of attention-deficit hyperactivity disorder: what are the first empirical results and putative clinical implications? Open
Attention-deficit hyperactivity disorder (ADHD) is one of the most common mental disorders in adolescents, and a full syndrome diagnosis requires a combination of persistent symptoms. In a multicentre cross-sectional study from Italy using…
View article: Social inhibition in depressed patients is associated with an altered activation profile of the interleukin-6-inducible transcription factor STAT3
Social inhibition in depressed patients is associated with an altered activation profile of the interleukin-6-inducible transcription factor STAT3 Open
These findings point towards a possible relationship between STAT3 signaling and social inhibition in depressed patients.
View article: Results from the Nationwide German KiGGS Study in Children and Adolescents Show that Myopia is Associated with Being an Only Child
Results from the Nationwide German KiGGS Study in Children and Adolescents Show that Myopia is Associated with Being an Only Child Open
Myopia, but not hyperopia, was significantly and positively related to only-child status, irrespective of confounders as age, sex, body-mass index, as well as socioeconomic and migration status. Further research is needed to decipher the p…
View article: Physical activity and psychopathology: are long-term developmental trajectories of physical activity in children and adolescents associated with trajectories of general mental health problems and of attention-deficit hyperactivity (ADHD) symptoms?
Physical activity and psychopathology: are long-term developmental trajectories of physical activity in children and adolescents associated with trajectories of general mental health problems and of attention-deficit hyperactivity (ADHD) symptoms? Open
A medium-to-high level of physical activity (PA) may have at least a short-term positive effect on psychopathology in children and adolescents. Hence, the objective of this study was to investigate the long-term effects of PA in non-adult …
View article: Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis
Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis Open
Background Aortic stenosis (AS) is one of the most common cardiac diseases and major cause of morbidity and mortality in the elderly. Transcatheter aortic valve implantation (TAVI) is performed in such patients with symptomatic severe AS a…
View article: A randomized vagus nerve stimulation study demonstrates that serum aldosterone levels decrease with age in women, but not in men
A randomized vagus nerve stimulation study demonstrates that serum aldosterone levels decrease with age in women, but not in men Open
In this randomized, sham-controlled study, we explored the effects of acute transcutaneous vagus nerve stimulation (tVNS) on serum aldosterone in 20 younger (21–26 years) and 19 older (40–70 years) healthy participants. Blood samples were …
View article: Associations of attention-deficit/hyperactivity disorder with inflammatory diseases. Results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS)
Associations of attention-deficit/hyperactivity disorder with inflammatory diseases. Results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS) Open
View article: A novel interface between the N-terminal and coiled-coil domain of STAT1 functions in an auto-inhibitory manner
A novel interface between the N-terminal and coiled-coil domain of STAT1 functions in an auto-inhibitory manner Open
Background STAT1 is an intracellular signaling molecule that is crucially involved in the regulation of the innate immune system by activation of defense mechanisms against microbial pathogens. Phosphorylation-dependent activation of the S…
View article: Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice Open
Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are ofte…
View article: Infarct‐Related Artery as a Donor of Collaterals in ST‐Segment–Elevation Myocardial Infarction With Concomitant Chronic Total Occlusion: Challenge of the Double‐Jeopardy Thesis
Infarct‐Related Artery as a Donor of Collaterals in ST‐Segment–Elevation Myocardial Infarction With Concomitant Chronic Total Occlusion: Challenge of the Double‐Jeopardy Thesis Open
BACKGROUND In ST‐segment–elevation myocardial infarction (STEMI), a concomitant chronic total occlusion (CTO) in a non–infarct‐related artery (NIRA) is associated with adverse outcome. In the case of the infarct‐related artery (IRA) as a d…
View article: Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction
Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction Open
In this study, we addressed the functional significance of co-operative DNA binding of the cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) in an experimental murine model of acute myocardial …
View article: Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms
Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms Open
View article: Long-term changes in serum levels of lipoproteins in children and adolescents with attention-deficit/hyperactivity disorder (ADHD)
Long-term changes in serum levels of lipoproteins in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) Open
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder affecting approximately 5% of children worldwide. The causal mechanisms of ADHD remain unclear as the aetiology of this disorder seems to be multifactorial. O…
View article: A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model
A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model Open
A variety of factors has been associated with healthy brain aging, and epidemiological studies suggest that physical activity and nutritional supplements such as caffeine may reduce the risk of developing dementia and, in particular, Alzhe…
View article: Is only-child status associated with a higher blood pressure in adolescence? An observational study
Is only-child status associated with a higher blood pressure in adolescence? An observational study Open
Growing up with siblings may affect quality of life as well as hemodynamic parameters including blood pressure. Using weighted data from the nationwide and representative German KiGGs study, we assessed the relationship between only-child …
View article: Type D Personality as a Risk Factor for Adverse Outcome in Patients With Cardiovascular Disease: An Individual Patient-Data Meta-analysis
Type D Personality as a Risk Factor for Adverse Outcome in Patients With Cardiovascular Disease: An Individual Patient-Data Meta-analysis Open
Objective Type D personality, a joint tendency toward negative affectivity and social inhibition, has been linked to adverse events in patients with heart disease, although with inconsistent findings. Here, we apply an individual patient-d…
View article: Physical activity and the development of general mental health problems or attention-deficit hyperactivity disorder (ADHD) symptoms in children and adolescents: A cross-lagged panel analysis of long-term follow-up epidemiological data
Physical activity and the development of general mental health problems or attention-deficit hyperactivity disorder (ADHD) symptoms in children and adolescents: A cross-lagged panel analysis of long-term follow-up epidemiological data Open
Studies have shown that physical activity (PA) can provide a helpful, low-risk, and cost-effective intervention for children and adolescents suffering from mental health problems. This longitudinal study aimed to assess whether PA prevents…
View article: Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor
Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor Open
Background Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that promotes cell proliferation and immunomodulation in untransformed cells and maintains stemness of transformed cells, facilitati…
View article: Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice Open
View article: An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form
An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form Open
Background Unphosphorylated signal transducer and activator of transcription 1 (U-STAT1) has been reported to elicit a distinct gene expression profile as compared to tyrosine-phosphorylated STAT1 (P-STAT1) homodimers. However, the impact …
View article: Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study Open
This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rh…
View article: Anwendungspraktische Limitationen bei der Aufklärung im Rahmen von Arzneimitteltherapien
Anwendungspraktische Limitationen bei der Aufklärung im Rahmen von Arzneimitteltherapien Open
View article: Kontaktzeiten im Profifußball vor der Covid-19-Pandemie – Eine retrospektive Analyse der Trackingdaten von Fußball-Bundesliga-Spielen
Kontaktzeiten im Profifußball vor der Covid-19-Pandemie – Eine retrospektive Analyse der Trackingdaten von Fußball-Bundesliga-Spielen Open
View article: Erfolgreiches ’Return to Football’ nach Covid-19 Lockdown 2020 – Eine Kohortenstudie zum Hygienekonzept des Deutschen Profifußballs
Erfolgreiches ’Return to Football’ nach Covid-19 Lockdown 2020 – Eine Kohortenstudie zum Hygienekonzept des Deutschen Profifußballs Open
View article: Keine erhöhte Verletzungsinzidenz in der 1. Fußball-Bundesliga nach dem Re-Start in Folge des SARS-CoV-2 Lockdowns 2020
Keine erhöhte Verletzungsinzidenz in der 1. Fußball-Bundesliga nach dem Re-Start in Folge des SARS-CoV-2 Lockdowns 2020 Open
View article: Increased Incidence of Perforated Appendicitis in Children During COVID-19 Pandemic in a Bavarian Multi-Center Study
Increased Incidence of Perforated Appendicitis in Children During COVID-19 Pandemic in a Bavarian Multi-Center Study Open
Introduction: Since early 2020 the COVID-19 pandemic and statutory preventive reorganization of treatment capacities with cancellation of elective surgery as well as curfew regulations led to vastly decreased utilization of primary health …
View article: Patient delay and benefit of timely reperfusion in ST-segment elevation myocardial infarction
Patient delay and benefit of timely reperfusion in ST-segment elevation myocardial infarction Open
Background In patients with ST-segment elevation myocardial infarction (STEMI), it is unknown how patient delay modulates the beneficial effects of timely reperfusion. Aims To assess the prognostic significance of a contact-to-balloon time…