Peter Heeringa
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View article: Memory B‐Cell Assay Uncovers Prior <scp>HLA</scp> Sensitisation in Transplant Candidates With Prior Exposure to Non‐Self <scp>HLA</scp>
Memory B‐Cell Assay Uncovers Prior <span>HLA</span> Sensitisation in Transplant Candidates With Prior Exposure to Non‐Self <span>HLA</span> Open
Memory B cells are critical in kidney transplantation for rapid anti‐HLA antibody production upon re‐exposure, yet pretransplant serum antibodies often remain undetectable despite prior sensitisation. Using R848 stimulation (a TLR7/8 agoni…
View article: Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis
Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis Open
Objectives Nasal carriage of toxic shock syndrome toxin-1 (TSST-1)-positive Staphylococcus aureus (SA) is associated with a high relapse rate in granulomatosis with polyangiitis (GPA), suggesting TSST-1’s role in disease progression. This …
View article: Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis
Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis Open
Objectives Giant cell arteritis (GCA) is a large vessel vasculitis characterized by arterial wall inflammation and remodeling. Macrophages and fibroblasts are abundantly present in arteries affected by GCA, but their crosstalk in GCA patho…
View article: Towards Therapeutic Targeting of Fibroblasts in Giant Cell Arteritis
Towards Therapeutic Targeting of Fibroblasts in Giant Cell Arteritis Open
Purpose of Review Giant cell arteritis (GCA) is characterized by chronic vascular inflammation and pathological remodeling. While current therapies primarily rely on broad immunosuppression by glucocorticoids, they fail to halt pathologic …
View article: Triggering trouble: post-translational modifications may drive myeloperoxidase autoimmunity
Triggering trouble: post-translational modifications may drive myeloperoxidase autoimmunity Open
View article: POS0081 MACROPHAGES DRIVE IL-6 PRODUCTION BY FIBROBLASTS THROUGH GALECTIN 3 IN POLYMYALGIA RHEUMATICA AND GIANT CELL ARTERITIS
POS0081 MACROPHAGES DRIVE IL-6 PRODUCTION BY FIBROBLASTS THROUGH GALECTIN 3 IN POLYMYALGIA RHEUMATICA AND GIANT CELL ARTERITIS Open
View article: POS0861 BEYOND IgG: EXPLORING THE ADDITIVE VALUE OF ANTI-MPO IgM IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS (AAV)
POS0861 BEYOND IgG: EXPLORING THE ADDITIVE VALUE OF ANTI-MPO IgM IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS (AAV) Open
View article: OP0023 Crosstalk between macrophages and fibroblasts likely contributes to inflammation and damage in giant cell arteritis
OP0023 Crosstalk between macrophages and fibroblasts likely contributes to inflammation and damage in giant cell arteritis Open
View article: Elevated Fab glycosylation of autoantibodies maintained during B cell depletion therapy
Elevated Fab glycosylation of autoantibodies maintained during B cell depletion therapy Open
View article: Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells With Early Antibody-mediated Rejection in Kidney Transplant Recipients
Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells With Early Antibody-mediated Rejection in Kidney Transplant Recipients Open
Background. B cells play a crucial role in kidney transplantation through antibody production and cytokine secretion. To better understand their impact on kidney transplantation, this retrospective study aimed to characterize circulating B…
View article: Distinct landscapes of fibroblast subtypes in arteries of patients with giant cell arteritis
Distinct landscapes of fibroblast subtypes in arteries of patients with giant cell arteritis Open
Objective Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries characterized by granulomatous inflammation and vascular remodelling. Although fibroblasts are the predominant cell type in the adventitia, t…
View article: Highlights from the plenary session: cellular and molecular mechanisms of disease (I)
Highlights from the plenary session: cellular and molecular mechanisms of disease (I) Open
In this plenary session of the Vasculitis Workshop 2024, pioneering translational research on autoimmune vasculitis, particularly ANCA-associated vasculitis (AAV), was presented, highlighting advancements in our understanding of disease me…
View article: Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis Open
View article: GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica
GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica Open
View article: Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension
Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension Open
Pulmonary arterial hypertension (PAH) is a disease characterized by pulmonary vascular remodeling. Since dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP) is associated with cardiovascular mortality in systemic sclerosis, a dis…
View article: Circulating B cells display differential immune regulatory molecule expression in granulomatosis with polyangiitis
Circulating B cells display differential immune regulatory molecule expression in granulomatosis with polyangiitis Open
Granulomatosis with polyangiitis (GPA) is a B-cell-mediated, relapsing, autoimmune disease. There is a need for novel therapeutic approaches and relapse markers to achieve durable remission. B cells express immune regulatory molecules that…
View article: Delineating sex-specific circulating host response signatures associated with COVID-19 severity and mortality
Delineating sex-specific circulating host response signatures associated with COVID-19 severity and mortality Open
View article: Current evidence on the role of fibroblasts in large-vessel vasculitides: From pathogenesis to therapeutics
Current evidence on the role of fibroblasts in large-vessel vasculitides: From pathogenesis to therapeutics Open
View article: Dephosphorylated uncarboxylated Matrix-Gla-Protein and vascular remodeling in pulmonary hypertension: an immunological connection
Dephosphorylated uncarboxylated Matrix-Gla-Protein and vascular remodeling in pulmonary hypertension: an immunological connection Open
Pulmonary arterial hypertension (PAH) is a disease characterized by pulmonary vascular remodeling. Since dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP) is associated with cardiovascular mortality in systemic sclerosis, a dis…
View article: Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity
Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity Open
Granulomatosis with polyangiitis (GPA) is an autoimmune disorder characterized by recurrent relapses that can cause severe tissue damage and life-threatening organ dysfunction. Multiple immune cells and cytokines/chemokines are involved in…
View article: Impaired IL-6-induced JAK-STAT signaling in CD4+ T cells associates with longer treatment duration in giant cell arteritis
Impaired IL-6-induced JAK-STAT signaling in CD4+ T cells associates with longer treatment duration in giant cell arteritis Open
Overall, in GCA, the percentages of in vitro IL-6-induced pSTAT3+CD4+T-cells likely reflect prior in vivo exposure to high IL-6 and may serve as a prognostic marker for GC-treatment duration and may assist improving personalized treatment …
View article: Memory B-cell derived donor-specific antibodies do not predict outcome in sensitized kidney transplant recipients: a retrospective single-center study
Memory B-cell derived donor-specific antibodies do not predict outcome in sensitized kidney transplant recipients: a retrospective single-center study Open
Background Repeated exposure to sensitizing events can activate HLA-specific memory B cells, leading to the production of donor-specific memory B cell antibodies (DSAm) that pose a risk for antibody-mediated rejection (ABMR) in kidney tran…
View article: Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment
Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment Open
Pemphigus vulgaris (PV) is a rare autoimmune bullous disease characterized by blistering of the skin and mucosa owing to the presence of autoantibodies against the desmosome proteins desmoglein 3 and occasionally in conjunction with desmog…
View article: Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis Open
B lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cell subsets and beneficial clinical effects of rituximab (anti-CD20) therapy. This treatment renders a long-term, perip…
View article: Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis
Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis Open
ANCA-associated vasculitides (AAV) are rare autoimmune diseases causing inflammation and damage to small blood vessels. New autoantibody biomarkers are needed to improve the diagnosis and treatment of AAV patients. In this study, we aimed …
View article: Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise
Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise Open
Introduction Immunoglobulin G (IgG) contains a conserved N-glycan in the fragment crystallizable (Fc), modulating its structure and effector functions. In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) alterations …
View article: Cytokine producing B-cells and their capability to polarize macrophages in giant cell arteritis
Cytokine producing B-cells and their capability to polarize macrophages in giant cell arteritis Open
View article: Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue
Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue Open
Obesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention suggests that SARS-CoV-2 disrupts adipos…
View article: Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica
Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica Open
Background Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are overlapping inflammatory diseases. Antigen-presenting cells (APCs), including monocytes and dendritic cells (DCs), are main contributors to the immunopathology of G…
View article: POS0100 TARGETING NF-ΚB SIGNALLING IN B LINEAGE CELLS AS A POTENTIAL NOVEL TREATMENT STRATEGY FOR ANCA-ASSOCIATED VASCULITIS
POS0100 TARGETING NF-ΚB SIGNALLING IN B LINEAGE CELLS AS A POTENTIAL NOVEL TREATMENT STRATEGY FOR ANCA-ASSOCIATED VASCULITIS Open