Peter Dixon
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View article: A genes and health recall study of intrahepatic cholestasis of pregnancy and cholestatic liver disease
A genes and health recall study of intrahepatic cholestasis of pregnancy and cholestatic liver disease Open
Background Cholestatic liver disease disproportionately affects South Asians, yet they remain underrepresented in genomic studies. This recall study aimed to recall volunteers from a British South Asian genetic cohort that were considered …
View article: Determining and predicting biochemical disease trajectory in intrahepatic cholestasis of pregnancy: A longitudinal cohort study
Determining and predicting biochemical disease trajectory in intrahepatic cholestasis of pregnancy: A longitudinal cohort study Open
Background The severity of intrahepatic cholestasis of pregnancy (ICP) reflects peak maternal bile acid (BA) concentration. However, the course of the disease is unclear. Methods Longitudinal observational cohort study of individuals with …
View article: Genetically Estimated Ancestry and the Risk of Pre-Eclampsia
Genetically Estimated Ancestry and the Risk of Pre-Eclampsia Open
SRE imperfectly represents genetic ancestry in multiethnic populations. West AFR ancestry independently associates with the PE risk, supporting biological relevance of ancestry-based stratification. However, genetic ancestry did not improv…
View article: Stillbirth in intrahepatic cholestasis of pregnancy and timing of severely elevated bile acid concentrations: an observational cohort study
Stillbirth in intrahepatic cholestasis of pregnancy and timing of severely elevated bile acid concentrations: an observational cohort study Open
A later gestation at which serum bile acids first rise over 100 μmol/L, and a later gestation at which bile acid concentration peaks, are both associated with a higher risk of stillbirth. A marked increase in bile acid concentration immedi…
View article: Characteristics associated with alterations in pruritus severity across gestation in intrahepatic cholestasis of pregnancy: a longitudinal cohort study
Characteristics associated with alterations in pruritus severity across gestation in intrahepatic cholestasis of pregnancy: a longitudinal cohort study Open
Higher peak bile acid concentrations and maternal BMI are associated with worsening pruritus severity in ICP.
View article: A Genes & Health pilot recall study of intrahepatic cholestasis of pregnancy and cholestatic liver disease
A Genes & Health pilot recall study of intrahepatic cholestasis of pregnancy and cholestatic liver disease Open
Background Cholestatic liver disease disproportionately affects South Asians, yet they remain underrepresented in genomic studies. This recall study aimed to recall volunteers from a British South Asian genetic cohort that were considered …
View article: Genetic issues in ICP
Genetic issues in ICP Open
Intrahepatic cholestasis of pregnancy (ICP) is the commonest gestational liver disorder with variable global incidence. Genetic susceptibility, combined with hormonal and environmental influences, contributes to ICP aetiology. Adverse preg…
View article: Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom
Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom Open
Objectives This study assessed the contribution of five genes previously known to be involved in cholestatic liver disease in British Bangladeshi and Pakistani people in the United Kingdom as they are an understudied genetic ancestry group…
View article: Ursodeoxycholic Acid in Intrahepatic Cholestasis of Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis
Ursodeoxycholic Acid in Intrahepatic Cholestasis of Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis Open
(Abstracted from Lancet Gastroenterol Hepatol 2021;6:547–558) Ursodeoxycholic acid (UA) is a common treatment for intrahepatic cholestasis of pregnancy (ICP), and its use is supported by the Society for Maternal-Fetal Medicine. However, ev…
View article: Additional file 1 of A multi-centre, open label, randomised, parallel-group, superiority Trial to compare the efficacy of URsodeoxycholic acid with RIFampicin in the management of women with severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC randomised trial
Additional file 1 of A multi-centre, open label, randomised, parallel-group, superiority Trial to compare the efficacy of URsodeoxycholic acid with RIFampicin in the management of women with severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC randomised trial Open
Additional file 1:. The approved master PICF for the TURRIFIC trial is attached as an appendix, together with a copy of the DSMC charter and the SPIRIT checklist.
View article: Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT
Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT Open
Background Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and raised serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth and neonatal unit admission. Ursodeoxycholic ac…
View article: Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial Open
Objective To evaluate whether a particular group of women with intrahepatic cholestasis of pregnancy (ICP), based on their presenting characteristics, would benefit from treatment with ursodeoxycholic acid (UDCA). Design Secondary analysis…
View article: G348(P) Ursodeoxycholic acid improves metabolic outcomes in the fetus, placenta and offspring of hypercholanemic pregnancy
G348(P) Ursodeoxycholic acid improves metabolic outcomes in the fetus, placenta and offspring of hypercholanemic pregnancy Open
Aims Perturbations in the intrauterine environment can result in lifelong consequences for fetal metabolic health. We previously showed that in humans, intrahepatic cholestasis of pregnancy (ICP) can predispose offspring to metabolic disea…
View article: Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial Open
Objective: To evaluate whether a particular group of women with intrahepatic cholestasis of pregnancy would benefit from treatment with ursodeoxycholic acid. Design: Secondary analysis of the PITCHES trial (ISRCTN91918806). Setting: United…
View article: Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy
Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy Open
Ursodeoxycholic acid (UDCA) treatment can reduce itch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP). We sought to determine how it could influence the gut environment in ICP to alter enterohepatic sig…
View article: spring viraemia of carp
spring viraemia of carp Open
This datasheet on spring viraemia of carp covers Identity, Overview, Associated Diseases, Pests or Pathogens, Distribution, Hosts/Species Affected, Diagnosis, Pathology, Epidemiology, Impacts, Prevention/Control, Further Information.
View article: Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis
Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis Open
Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia, and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal conte…
View article: Heart and bile acids – Clinical consequences of altered bile acid metabolism
Heart and bile acids – Clinical consequences of altered bile acid metabolism Open
Cardiac dysfunction has an increased prevalence in diseases complicated by liver cirrhosis such as primary biliary cholangitis and primary sclerosing cholangitis. This observation has led to research into the association between abnormalit…