Peter Hewins
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View article: Paternal immune activation protects offspring from severe disease during viral infection 3329
Paternal immune activation protects offspring from severe disease during viral infection 3329 Open
Description Maternal immune activation during gestation can influence offspring behavior and immunity. However, the influence of paternal immune activation (PIA) on progeny is understudied. Limited evidence indicates that PIA influences of…
View article: E085 Real world use of voclosporin to treat lupus nephritis
E085 Real world use of voclosporin to treat lupus nephritis Open
Background/Aims Voclosporin is a novel calcineurin inhibitor approved for the treatment of lupus nephritis (LN) in the UK in 2023. We present our current local experience using voclosporin at Queen Elizabeth Hospital Birmingham. Methods Ro…
View article: Differences in management approaches for lupus nephritis within the UK
Differences in management approaches for lupus nephritis within the UK Open
Objectives Outcomes of therapy for LN are often suboptimal. Guidelines offer varied options for treatment of LN and treatment strategies may differ between clinicians and regions. We aimed to assess variations in the usual practice of UK p…
View article: Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice
Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice Open
Endothelial damage and vascular pathology have been recognized as major features of COVID-19 since the beginning of the pandemic. Two main theories regarding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) damages endothel…
View article: Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice
Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice Open
Endothelial damage and vascular pathology have been recognized as major features of COVID-19 since the beginning of the pandemic. Two main theories regarding how Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) damages endothel…
View article: Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil
Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil Open
Background Systemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in predicted immune cell f…
View article: OA20 Differences in management approaches for lupus nephritis within the UK
OA20 Differences in management approaches for lupus nephritis within the UK Open
Background/Aims Outcomes of current therapy for lupus nephritis (LN) are suboptimal. Guidelines offer varied options for treatment of LN at onset, for refractory disease or relapse. Recent randomised trials have demonstrated the efficacy o…
View article: Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection
Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection Open
Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in Coronavirus Disease 2019 (COVID-19) pathogenesis is indisputable, there remains…
View article: An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant
An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant Open
The SARS-CoV2 Omicron variant sub-lineages spread rapidly through the world, mostly due to their immune-evasive properties. This has put a significant part of the population at risk for severe disease and underscores the need for anti-SARS…
View article: SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice
SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice Open
Lethal COVID-19 is associated with respiratory failure that is thought to be caused by acute respiratory distress syndrome (ARDS) secondary to pulmonary infection. To date, the cellular pathogenesis has been inferred from studies describin…
View article: Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis
Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis Open
Antineutrophil cytoplasmic autoantibody (ANCA) causes vascular injury that leads to small-vessel vasculitis. Patients with ANCA aberrantly express neutrophil granule–encoding genes, including 2 that encode autoantigens: proteinase 3 (PR3) …
View article: Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by ‘autoantigen complementarity’
Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by ‘autoantigen complementarity’ Open
‘Autoantigen complementarity’ is a theory proposing that the initiator of an autoimmune response is not necessarily the autoantigen or its molecular mimic, but may instead be a peptide that is ‘antisense/complementary’ to the autoantigen. …
View article: Longitudinal studies of patients with ANCA vasculitis demonstrate concurrent reactivity to complementary PR3 protein segments cPR3m and cPR3C and with no reactivity to cPR3N
Longitudinal studies of patients with ANCA vasculitis demonstrate concurrent reactivity to complementary PR3 protein segments cPR3m and cPR3C and with no reactivity to cPR3N Open
Antibodies recognizing the complement of the middle of PR3 (cPR3m) occur in ~30% of PR3-ANCA-vasculitis patients and immunization of animals with a peptide complementary to the middle of PR3 (cPR3m) induces not only anti-complementary PR3 …
View article: P121 Identification and active management of secondary adrenal insufficiency in SLE reduces risk of relapse
P121 Identification and active management of secondary adrenal insufficiency in SLE reduces risk of relapse Open
Background Steroids are an important component of Lupus treatment, but long-term use is associated with an accumulation of damage, emphasising the importance of optimising steroid withdrawal protocols. The factors influencing successful st…
View article: Adult minimal-change disease: observational data from a UK centre on patient characteristics, therapies, and outcomes
Adult minimal-change disease: observational data from a UK centre on patient characteristics, therapies, and outcomes Open
Nearly all adults with MCD achieve remission, but relapses and disease- and therapy-related complications are common. In our cohort, eGFR and gender were associated with risk of relapse, and these previously undescribed associations could …
View article: The efficacy of rituximab in adult frequently relapsing minimal change disease
The efficacy of rituximab in adult frequently relapsing minimal change disease Open
RTX is safe and effective in adults with FRNS due to MCD. The median rate of relapse is significantly reduced following RTX treatment and additional immunosuppressant exposure is minimized.
View article: 290. Long-Term Outcome of Treatment with Mycophenolate Mofetil for Lupus Nephritis
290. Long-Term Outcome of Treatment with Mycophenolate Mofetil for Lupus Nephritis Open
Background: MMF is increasingly being used as an alternative to CYC for induction and maintenance therapy in LN.However, there are few long-term outcome data.The aim of this audit was to assess the efficacy of MMF on renal outcomes over 5 …