Peter Heeringa
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View article: Circulating peripheral helper T cells are expanded and associate with disease activity in granulomatosis with polyangiitis
Circulating peripheral helper T cells are expanded and associate with disease activity in granulomatosis with polyangiitis Open
cTph cells are expanded and exhibit an activated, pro-inflammatory profile with a cTph2-skewed distribution in active GPA-patients. Their association with disease activity may support a potential role in disease pathogenesis and highlight …
View article: Memory B‐Cell Assay Uncovers Prior <scp>HLA</scp> Sensitisation in Transplant Candidates With Prior Exposure to Non‐Self <scp>HLA</scp>
Memory B‐Cell Assay Uncovers Prior <span>HLA</span> Sensitisation in Transplant Candidates With Prior Exposure to Non‐Self <span>HLA</span> Open
Memory B cells are critical in kidney transplantation for rapid anti‐HLA antibody production upon re‐exposure, yet pretransplant serum antibodies often remain undetectable despite prior sensitisation. Using R848 stimulation (a TLR7/8 agoni…
View article: Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis
Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis Open
Objectives Nasal carriage of toxic shock syndrome toxin-1 (TSST-1)-positive Staphylococcus aureus (SA) is associated with a high relapse rate in granulomatosis with polyangiitis (GPA), suggesting TSST-1’s role in disease progression. This …
View article: Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis
Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis Open
Objectives Giant cell arteritis (GCA) is a large vessel vasculitis characterized by arterial wall inflammation and remodelling. Macrophages and fibroblasts are abundantly present in arteries affected by GCA, but their crosstalk in GCA path…
View article: Towards Therapeutic Targeting of Fibroblasts in Giant Cell Arteritis
Towards Therapeutic Targeting of Fibroblasts in Giant Cell Arteritis Open
Purpose of Review Giant cell arteritis (GCA) is characterized by chronic vascular inflammation and pathological remodeling. While current therapies primarily rely on broad immunosuppression by glucocorticoids, they fail to halt pathologic …
View article: Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells With Early Antibody-mediated Rejection in Kidney Transplant Recipients
Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells With Early Antibody-mediated Rejection in Kidney Transplant Recipients Open
Background. B cells play a crucial role in kidney transplantation through antibody production and cytokine secretion. To better understand their impact on kidney transplantation, this retrospective study aimed to characterize circulating B…
View article: Distinct landscapes of fibroblast subtypes in arteries of patients with giant cell arteritis
Distinct landscapes of fibroblast subtypes in arteries of patients with giant cell arteritis Open
Objective Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries characterized by granulomatous inflammation and vascular remodelling. Although fibroblasts are the predominant cell type in the adventitia, t…
View article: Highlights from the plenary session: cellular and molecular mechanisms of disease (I)
Highlights from the plenary session: cellular and molecular mechanisms of disease (I) Open
In this plenary session of the Vasculitis Workshop 2024, pioneering translational research on autoimmune vasculitis, particularly ANCA-associated vasculitis (AAV), was presented, highlighting advancements in our understanding of disease me…
View article: Circulating B cells display differential immune regulatory molecule expression in granulomatosis with polyangiitis
Circulating B cells display differential immune regulatory molecule expression in granulomatosis with polyangiitis Open
Granulomatosis with polyangiitis (GPA) is a B-cell-mediated, relapsing, autoimmune disease. There is a need for novel therapeutic approaches and relapse markers to achieve durable remission. B cells express immune regulatory molecules that…
View article: Dephosphorylated uncarboxylated Matrix-Gla-Protein and vascular remodeling in pulmonary hypertension: an immunological connection
Dephosphorylated uncarboxylated Matrix-Gla-Protein and vascular remodeling in pulmonary hypertension: an immunological connection Open
Pulmonary arterial hypertension (PAH) is a disease characterized by pulmonary vascular remodeling. Since dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP) is associated with cardiovascular mortality in systemic sclerosis, a dis…
View article: Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity
Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity Open
Granulomatosis with polyangiitis (GPA) is an autoimmune disorder characterized by recurrent relapses that can cause severe tissue damage and life-threatening organ dysfunction. Multiple immune cells and cytokines/chemokines are involved in…
View article: Altered Plasma Levels and Tissue Expression of Fibroblast Activation Protein Alpha in Giant Cell Arteritis
Altered Plasma Levels and Tissue Expression of Fibroblast Activation Protein Alpha in Giant Cell Arteritis Open
Objective Giant cell arteritis (GCA) is characterized by granulomatous inflammation of the medium‐ and large‐sized arteries accompanied by remodeling of the vessel wall. Fibroblast activation protein alpha (FAP) is a serine protease that p…
View article: Impaired IL-6-induced JAK-STAT signaling in CD4+ T cells associates with longer treatment duration in giant cell arteritis
Impaired IL-6-induced JAK-STAT signaling in CD4+ T cells associates with longer treatment duration in giant cell arteritis Open
Overall, in GCA, the percentages of in vitro IL-6-induced pSTAT3+CD4+T-cells likely reflect prior in vivo exposure to high IL-6 and may serve as a prognostic marker for GC-treatment duration and may assist improving personalized treatment …
View article: Memory B-cell derived donor-specific antibodies do not predict outcome in sensitized kidney transplant recipients: a retrospective single-center study
Memory B-cell derived donor-specific antibodies do not predict outcome in sensitized kidney transplant recipients: a retrospective single-center study Open
Background Repeated exposure to sensitizing events can activate HLA-specific memory B cells, leading to the production of donor-specific memory B cell antibodies (DSAm) that pose a risk for antibody-mediated rejection (ABMR) in kidney tran…
View article: Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment
Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment Open
Pemphigus vulgaris (PV) is a rare autoimmune bullous disease characterized by blistering of the skin and mucosa owing to the presence of autoantibodies against the desmosome proteins desmoglein 3 and occasionally in conjunction with desmog…
View article: Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis Open
B lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cell subsets and beneficial clinical effects of rituximab (anti-CD20) therapy. This treatment renders a long-term, perip…
View article: Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis
Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis Open
ANCA-associated vasculitides (AAV) are rare autoimmune diseases causing inflammation and damage to small blood vessels. New autoantibody biomarkers are needed to improve the diagnosis and treatment of AAV patients. In this study, we aimed …
View article: Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise
Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise Open
Introduction Immunoglobulin G (IgG) contains a conserved N-glycan in the fragment crystallizable (Fc), modulating its structure and effector functions. In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) alterations …
View article: Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica
Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica Open
Background Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are overlapping inflammatory diseases. Antigen-presenting cells (APCs), including monocytes and dendritic cells (DCs), are main contributors to the immunopathology of G…