J. Li
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View article: Elucidating a Myofibroblast-dominated Fibrotic Niche in Crohn’s Disease-associated Fibrostenosis Through High-resolution Spatial Transcriptomics
Elucidating a Myofibroblast-dominated Fibrotic Niche in Crohn’s Disease-associated Fibrostenosis Through High-resolution Spatial Transcriptomics Open
This case-level, high-resolution spatial analysis delineates a spatially organized fibrotic niche within a CD stricture, composed of distinct stromal and immune populations. We define the identity and origins of profibrotic myofibroblasts …
View article: Scaling laws for activation steering with Llama 2 models and refusal mechanisms
Scaling laws for activation steering with Llama 2 models and refusal mechanisms Open
As large language models (LLMs) evolve in complexity and capability, the efficacy of less widely deployed alignment techniques are uncertain. Building on previous work on activation steering and contrastive activation addition (CAA), this …
View article: GOTO065054+593624: An 8.5 mag amplitude dwarf nova identified in real time via Kilonova Seekers
GOTO065054+593624: An 8.5 mag amplitude dwarf nova identified in real time via Kilonova Seekers Open
Dwarf novae are astrophysical laboratories for probing the nature of accretion, binary mass transfer, and binary evolution, but their diverse observational characteristics continue to challenge our theoretical understanding. We here presen…
View article: Search for high-mass resonances in a final state comprising a gluon and two hadronically decaying W bosons in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV
Search for high-mass resonances in a final state comprising a gluon and two hadronically decaying W bosons in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV Open
A bstract A search for high-mass resonances decaying into a gluon, g, and two W bosons is presented. A Kaluza-Klein gluon, g KK , decaying in cascade via a scalar radion R, g KK → gR → gWW, is considered. The final state studied consists o…
View article: GOTO065054+593624: a 8.5 mag amplitude dwarf nova identified in real time via Kilonova Seekers
GOTO065054+593624: a 8.5 mag amplitude dwarf nova identified in real time via Kilonova Seekers Open
Dwarf novae are astrophysical laboratories for probing the nature of accretion, binary mass transfer, and binary evolution -- yet their diverse observational characteristics continue to challenge our theoretical understanding. We here pres…
View article: Exploring Surface-Driven Mechanisms for Low-Temperature Sintering of Nanoscale Copper
Exploring Surface-Driven Mechanisms for Low-Temperature Sintering of Nanoscale Copper Open
As the density of electronic packaging continues to rise, traditional soldering techniques encounter significant challenges, leading to copper–copper direct bonding as a new high-density connection method. The high melting point of copper …
View article: An Improved ADRC Design Based on a Generalized Differentiator for a Nonlinear Hydraulic Turbine Regulating System
An Improved ADRC Design Based on a Generalized Differentiator for a Nonlinear Hydraulic Turbine Regulating System Open
In recent years, with the advancement of renewable energy technologies, hydropower has assumed an increasingly important regulatory and balancing role in the power system. It plays an important role in grid frequency stability. This requir…
View article: Search for vector-like leptons with long-lived particle decays in the CMS muon system in proton-proton collisions at $\sqrt{s}$ = 13 TeV
Search for vector-like leptons with long-lived particle decays in the CMS muon system in proton-proton collisions at $\sqrt{s}$ = 13 TeV Open
A first search is presented for vector-like leptons (VLLs) decaying into a light long-lived pseudoscalar boson and a standard model $\tau$ lepton. The pseudoscalar boson is assumed to have a mass of 2 GeV and to decay exclusively into a pa…
View article: Small-$x$ evolution of gluon fields from incoherent J/$\psi$ photoproduction in ultraperipheral PbPb collisions
Small-$x$ evolution of gluon fields from incoherent J/$\psi$ photoproduction in ultraperipheral PbPb collisions Open
Incoherent J/$\psi$ photoproduction in heavy ion ultraperipheral collisions (UPCs), in which the photon interacts with localized, fluctuating gluonic hotspots rather than the entire nucleus, provides a unique probe of those fluctuations. T…
View article: IntComplex for high-order interactions
IntComplex for high-order interactions Open
Graphs serve as powerful tools for modeling pairwise interactions in diverse fields such as biology, material science, and social networks. However, they inherently overlook interactions involving more than two entities. Simplicial complex…
View article: Enhancing radiosensitivity in osteosarcoma via CDKN2C overexpression: A mechanism involving G1 phase arrest mediated by inhibition of CDK4 expression and Thr172 phosphorylation
Enhancing radiosensitivity in osteosarcoma via CDKN2C overexpression: A mechanism involving G1 phase arrest mediated by inhibition of CDK4 expression and Thr172 phosphorylation Open
Our research results indicate that overexpression of CDKN2C enhances radiosensitivity in osteosarcoma through the induction of G1 phase arrest and subsequent apoptosis. G1 phase arrest is mediated by the suppression of CDK4 expression and …
View article: P27.07.A EFFICACY AND SAFETY OF STUPP REGIMEN WITH OR WITHOUT ANLOTINIB FOR NEWLY DIAGNOSED GLIOBLASTOMA: A MULTICENTER, DOUBLE-BLIND, RANDOMIZED PHASE II TRIAL
P27.07.A EFFICACY AND SAFETY OF STUPP REGIMEN WITH OR WITHOUT ANLOTINIB FOR NEWLY DIAGNOSED GLIOBLASTOMA: A MULTICENTER, DOUBLE-BLIND, RANDOMIZED PHASE II TRIAL Open
BACKGROUND The STUPP regimen, which consists of postoperative radiotherapy with concurrent temozolomide (TMZ) followed by up to six cycles of adjuvant TMZ chemotherapy, is the established standard treatment for newly diagnosed glioblastoma…
View article: [Swertiamarin ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting intestinal epithelial cell apoptosis].
[Swertiamarin ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting intestinal epithelial cell apoptosis]. Open
STM inhibits intestinal epithelial cell apoptosis at least in part by suppressing activation of the PI3K/AKT pathway to ameliorate intestinal barrier dysfunction and colitis in mice.
View article: Double low-dose computed tomography (CT) angiography of craniocervical arteries using a test bolus of diluted contrast medium and a personalized contrast protocol
Double low-dose computed tomography (CT) angiography of craniocervical arteries using a test bolus of diluted contrast medium and a personalized contrast protocol Open
With double-low-dose cc-CTA, test bolus scanning based on diluted CM combined with a personalized contrast protocol can yield diagnostic-quality images and significantly reduce the radiation and CM doses.
View article: Search for pair production of scalar and vector leptoquarks decaying to muons and bottom quarks in proton-proton collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>13</mml:mn><mml:mtext> </mml:mtext><mml:mtext> </mml:mtext><mml:mi>TeV</mml:mi></mml:math>
Search for pair production of scalar and vector leptoquarks decaying to muons and bottom quarks in proton-proton collisions at Open
A search for pair production of scalar and vector leptoquarks (LQs) each decaying to a muon and a bottom quark is performed using proton-proton collision data collected at s=13 TeV with the CMS detector at the CERN LHC, corresponding to a…
View article: Homotopy Groups and Puppe Sequence of Digraphs
Homotopy Groups and Puppe Sequence of Digraphs Open
We introduce homotopy groups of digraphs that admit an intuitive description of grid structures, which is a variation of the GLMY homotopy groups introduced by Grigor'yan, Lin, Muranov and Yau in 2014. This direct approach enables a descri…
View article: Search for charged-lepton flavor violation in the production and decay of top quarks using trilepton final states
Search for charged-lepton flavor violation in the production and decay of top quarks using trilepton final states Open
This document describes a search for charged-lepton flavor violation (CLFV) in the production and decay of top quarks using 138 fb$^{-1}$ of data collected by the CMS experiment at a center-of-mass energy of 13 TeV. Events are selected for…
View article: Recruitment of PVT1 Enhances YTHDC1-Mediated m6A Modification of IL-33 in Hyperoxia-Induced Lung Injury During Bronchopulmonary Dysplasia
Recruitment of PVT1 Enhances YTHDC1-Mediated m6A Modification of IL-33 in Hyperoxia-Induced Lung Injury During Bronchopulmonary Dysplasia Open
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that specifically affects preterm infants. Oxygen therapy administered to treat BPD can lead to hyperoxia-induced lung injury, characterized by apoptosis of lung alveolar epithelia…
View article: Biomineralized tetramethylpyrazine-loaded PCL/Gelatin nanofibrous membrane promotes vascularization and bone regeneration of rat cranium defects
Biomineralized tetramethylpyrazine-loaded PCL/Gelatin nanofibrous membrane promotes vascularization and bone regeneration of rat cranium defects Open
Conventional electrospinning produces nanofibers with smooth surfaces that limit biomineralization ability. To overcome this disadvantage, we fabricated a tetramethylpyrazine (TMP)-loaded matrix-mimicking biomineralization in PCL/Gelatin c…
View article: A histopathological image classification method for cholangiocarcinoma based on spatial-channel feature fusion convolution neural network
A histopathological image classification method for cholangiocarcinoma based on spatial-channel feature fusion convolution neural network Open
Histopathological image analysis plays an important role in the diagnosis and treatment of cholangiocarcinoma. This time-consuming and complex process is currently performed manually by pathologists. To reduce the burden on pathologists, t…
View article: Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling
Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling Open
Background: The present study aimed to investigate the protective effect of the water extract of Amydrium sinense (Engl.) H. Li (ASWE) against hepatic fibrosis (HF) and clarify the underlying mechanism. Methods: The chemical components of …
View article: Influencing factors of medication literacy among community-dwelling older adult patients with hypertension: a study based on social learning theory
Influencing factors of medication literacy among community-dwelling older adult patients with hypertension: a study based on social learning theory Open
Objective: This study aimed to examine the factors affecting medication literacy in community-dwelling older adults with hypertension, guided by social learning theory. It sought to analyze the pathways these factors influenced and provide…
View article: The magnitude homology of a hypergraph
The magnitude homology of a hypergraph Open
The magnitude homology, introduced by R. Hepworth and S. Willerton, offers a topological invariant that enables the study of graph properties. Hypergraphs, being a generalization of graphs, serve as popular mathematical models for data wit…