Peter K. Kaiser
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View article: Impact of Central Subfield Thickness Fluctuations on Visual Outcomes in Neovascular Age-Related Macular Degeneration in the VIEW Trials
Impact of Central Subfield Thickness Fluctuations on Visual Outcomes in Neovascular Age-Related Macular Degeneration in the VIEW Trials Open
Purpose: To evaluate the impact of central subfield thickness (CST) fluctuations on visual outcomes in treatment-naïve eyes with neovascular age-related macular degeneration from VIEW 1 and VIEW 2. Methods: Eyes were treated with intravitr…
View article: Differential Visual Outcomes in Neovascular AMD Based on Ellipsoid Zone Integrity and Fluid Presence: Insights from a Phase III Trial
Differential Visual Outcomes in Neovascular AMD Based on Ellipsoid Zone Integrity and Fluid Presence: Insights from a Phase III Trial Open
Background/Objectives: To investigate the effect of ellipsoid zone (EZ) integrity and retinal fluid on best-corrected visual acuity (BCVA) in neovascular, age-related macular degeneration. Methods: This was a post hoc treatment-agnostic an…
View article: The impact potential of aflibercept biosimilars
The impact potential of aflibercept biosimilars Open
View article: Initial Functional and Anatomical Outcomes of High-dose Aflibercept 8 mg in Exudative Neovascular Age-related Macular Degeneration
Initial Functional and Anatomical Outcomes of High-dose Aflibercept 8 mg in Exudative Neovascular Age-related Macular Degeneration Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Determinants of Four-Year Visual Acuity Loss in Geographic Atrophy
Determinants of Four-Year Visual Acuity Loss in Geographic Atrophy Open
Proprietary or commercial disclosure may be found after the references.
View article: Pilot and feasibility studies in ophthalmology: fundamental keys to success
Pilot and feasibility studies in ophthalmology: fundamental keys to success Open
View article: ReCLAIM-2: A Randomized Phase II Clinical Trial Evaluating Elamipretide in Age-related Macular Degeneration, Geographic Atrophy Growth, Visual Function, and Ellipsoid Zone Preservation
ReCLAIM-2: A Randomized Phase II Clinical Trial Evaluating Elamipretide in Age-related Macular Degeneration, Geographic Atrophy Growth, Visual Function, and Ellipsoid Zone Preservation Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Imaging-Guided Classification of Neovascularization in Neovascular Age-Related Macular Degeneration: Progress to Date
Imaging-Guided Classification of Neovascularization in Neovascular Age-Related Macular Degeneration: Progress to Date Open
Purpose: To review the evolution of terminology describing the classification of lesions in neovascular age-related macular degeneration (nAMD) based on retinal imaging technologies. Methods: A review of the current and historical literatu…
View article: Update on Retinal Drug Safety: Proceedings of the ASRS ReST Committee Webinar Part 1
Update on Retinal Drug Safety: Proceedings of the ASRS ReST Committee Webinar Part 1 Open
Purpose: To review the first Research and Safety in Therapeutics (ReST) Committee webinar and summarize the most current recommendations regarding diagnosis and management. Methods: The ReST Committee is comprised of members of the America…
View article: International Classification System for Ocular Complications of Anti-VEGF Agents in Clinical Trials
International Classification System for Ocular Complications of Anti-VEGF Agents in Clinical Trials Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: EFFICACY AND SAFETY OF THE PROPOSED BIOSIMILAR AFLIBERCEPT, SDZ-AFL, IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
EFFICACY AND SAFETY OF THE PROPOSED BIOSIMILAR AFLIBERCEPT, SDZ-AFL, IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION Open
Purpose: The Phase 3 Mylight study was designed to confirm clinical equivalence of proposed biosimilar aflibercept (SOK583A1; Sandoz [proposed biosimilar aflibercept, SDZ-AFL]) to its reference biologic (Eylea; Regeneron Pharmaceuticals, I…
View article: Crossing Numbers of Billiard Curves in the Multidimensional Box via Translation Surfaces
Crossing Numbers of Billiard Curves in the Multidimensional Box via Translation Surfaces Open
The billiard table is modeled as an $n$-dimensional box $[0,a_1]\times [0,a_2]\times \ldots \times [0,a_n] \subset \mathbb{R}^n$, with each side having real-valued lengths $a_i$ that are pairwise commensurable. A ball is launched from the …
View article: Vision Loss Reduction with Avacincaptad Pegol for Geographic Atrophy
Vision Loss Reduction with Avacincaptad Pegol for Geographic Atrophy Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: The ophthalmologist’s guide to evaluating the certainty of evidence using the GRADE approach
The ophthalmologist’s guide to evaluating the certainty of evidence using the GRADE approach Open
View article: Considerations for the Identification and Management of Geographic Atrophy: Recommendations from an Expert Panel
Considerations for the Identification and Management of Geographic Atrophy: Recommendations from an Expert Panel Open
Newly approved treatments for patients with geographic atrophy are changing the treatment paradigm, highlighting the need for eye care providers (ECPs) to have a set of recommendations on how to best manage GA patients. Here, we outline ho…
View article: Bispecific VEGF-A and Angiopoietin-2 Antagonist RO-101 Preclinical Efficacy in Model of Neovascular Eye Disease
Bispecific VEGF-A and Angiopoietin-2 Antagonist RO-101 Preclinical Efficacy in Model of Neovascular Eye Disease Open
View article: Mother, child and adolescent health outcomes in two long-term refugee camp settings at the Thai-Myanmar border 2000–2018: a retrospective analysis
Mother, child and adolescent health outcomes in two long-term refugee camp settings at the Thai-Myanmar border 2000–2018: a retrospective analysis Open
Aim: The study assessed mothers, children and adolescents’ health (MCAH) outcomes in the context of a Primary Health Care (PHC) project and associated costs in two protracted long-term refugee camps, along the Thai-Myanmar border. Backgrou…
View article: Crossing Numbers of Billiard Curves in the Multidimensional Box Via Translation Surfaces
Crossing Numbers of Billiard Curves in the Multidimensional Box Via Translation Surfaces Open
View article: Geographic Atrophy Management Consensus (GA-MAC): a Delphi panel study on identification, diagnosis and treatment
Geographic Atrophy Management Consensus (GA-MAC): a Delphi panel study on identification, diagnosis and treatment Open
Background/aims With a paradigm shift in geographic atrophy (GA) treatments now available, establishing consensus on the identification and diagnosis of the disease along with considerations for management of patients with GA will assist e…
View article: Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial
Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial Open
View article: Potential for Treatment Interval Extension in Eyes with nAMD Disease Activity Post Loading Phase in HAWK and HARRIER
Potential for Treatment Interval Extension in Eyes with nAMD Disease Activity Post Loading Phase in HAWK and HARRIER Open
These findings indicate that, in eyes that still had DA 8 weeks after the final dose of loading phase, brolucizumab-treated eyes had improved fluid resolution and higher potential for treatment interval extension than aflibercept-treated e…
View article: Correction: The 5 min meta-analysis: understanding how to read and interpret a forest plot
Correction: The 5 min meta-analysis: understanding how to read and interpret a forest plot Open
View article: Anti‐vascular endothelial growth factor therapy and retinal non‐perfusion in diabetic retinopathy: A meta‐analysis of randomised trials
Anti‐vascular endothelial growth factor therapy and retinal non‐perfusion in diabetic retinopathy: A meta‐analysis of randomised trials Open
Purpose Retinal non‐perfusion (RNP) is fundamental to disease onset and progression in diabetic retinopathy (DR). Whether anti‐vascular endothelial growth factor (anti‐VEGF) therapy can modify RNP progression is unclear. This investigation…
View article: What makes a good survey?
What makes a good survey? Open
View article: Sustained Ocular Delivery of Bevacizumab Using Densomeres in Rabbits: Effects on Molecular Integrity and Bioactivity
Sustained Ocular Delivery of Bevacizumab Using Densomeres in Rabbits: Effects on Molecular Integrity and Bioactivity Open
The Densomere platform provides a significant opportunity for prolonged delivery of biologics in ocular and other tissues.
View article: Noninferiority randomised trials in ophthalmology
Noninferiority randomised trials in ophthalmology Open
View article: Interpreting results from randomized controlled trials: What measures to focus on in clinical practice
Interpreting results from randomized controlled trials: What measures to focus on in clinical practice Open
View article: The need for a pragmatic, individualized treat-and-extend (T&E) treatment paradigm for centre-involving diabetic macular oedema
The need for a pragmatic, individualized treat-and-extend (T&E) treatment paradigm for centre-involving diabetic macular oedema Open
View article: Biosimilars for retinal diseases: United States-Europe awareness survey (Bio-USER – survey)
Biosimilars for retinal diseases: United States-Europe awareness survey (Bio-USER – survey) Open
The Bio-USER survey revealed that while the majority of retinal physicians need additional information regarding the safety, efficacy and immunogenicity when making clinical decisions regarding their use. Retinal physicians from US are mor…
View article: Nerve entrapment syndromes: detection by ultrasound
Nerve entrapment syndromes: detection by ultrasound Open
Nerve entrapment syndromes are commonly encountered in clinical practice. Accurate diagnosis and management require a knowledge of peripheral neuroanatomy and the recognition of key clinical symptoms and findings. Nerve entrapment syndrome…