Péter Klivènyi
YOU?
Author Swipe
View article: Cognitive Profiling in Focal Dystonia: Selective Executive, Working Memory and Attention Impairments Revealed by Domain-Specific Testing - A Case-Control Study
Cognitive Profiling in Focal Dystonia: Selective Executive, Working Memory and Attention Impairments Revealed by Domain-Specific Testing - A Case-Control Study Open
Background: Previous studies examining the level and pattern of cognitive impairment in focal dystonias have yielded inconsistent results. Therefore, further prospective research comparing patients with precisely matched healthy controls –…
View article: Expanding the Genetic and Phenotypic Spectrum of <scp>DYT</scp> ‐ <scp> <i>VPS16</i> </scp> : The Importance of Splice‐Site Variants
Expanding the Genetic and Phenotypic Spectrum of <span>DYT</span> ‐ <span> <i>VPS16</i> </span> : The Importance of Splice‐Site Variants Open
Background DYT ‐ VPS16 , an early‐onset isolated dystonia caused by variants in the VPS16 gene, has been reported in fewer than 70 patients. Methods We explored the clinical and genotypic spectrum of DYT ‐ VPS16 by investigating early‐onse…
View article: Genetic Variants in SDC3, KCNA2, KCNK1, KCNK16, and Heat Shock Transcription Factor-1 Genes: An Exploratory Analysis Supporting the Piezo2 Channelopathy Hypothesis in Amyotrophic Lateral Sclerosis Onset
Genetic Variants in SDC3, KCNA2, KCNK1, KCNK16, and Heat Shock Transcription Factor-1 Genes: An Exploratory Analysis Supporting the Piezo2 Channelopathy Hypothesis in Amyotrophic Lateral Sclerosis Onset Open
Amyotrophic lateral sclerosis (ALS) is a multisystem progressive neurodegenerative disease. A recent theory of ALS onsetting pathogenesis proposed that the initiating primary damage is an acquired irreversible intrafusal proprioceptive ter…
View article: The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis
The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis Open
Systemic immune changes have been implicated in amyotrophic lateral sclerosis (ALS), but precise mechanisms and cellular targets remain unknown. Neuromuscular junction (NMJ) denervation is another major pathophysiological event in ALS, but…
View article: Fatal Outcome of Intravenous Thrombolysis With an Unexpected Finding of Amyloid‐β‐Related Angiitis—A Case Report Highlighting a Relevant Scenario With Acute Focal Neurological Deficits and Minimal Radiological Presentation
Fatal Outcome of Intravenous Thrombolysis With an Unexpected Finding of Amyloid‐β‐Related Angiitis—A Case Report Highlighting a Relevant Scenario With Acute Focal Neurological Deficits and Minimal Radiological Presentation Open
Cerebral amyloid angiopathy (CAA) has been implicated as a risk for developing lobar intracerebral hemorrhage (ICH) after intravenous thrombolysis (IVT) applied for acute ischemic stroke (AIS). However, there is a paucity of cases reported…
View article: Device‐Aided Treatment of Parkinsonism in Cerebrotendinous Xanthomatosis
Device‐Aided Treatment of Parkinsonism in Cerebrotendinous Xanthomatosis Open
View article: Long-Term Cuprizone Administration Resulted in Cognitive Decline and Kynurenine Metabolic Disturbance
Long-Term Cuprizone Administration Resulted in Cognitive Decline and Kynurenine Metabolic Disturbance Open
The cuprizone (CPZ) toxin-induce animal model is suitable for studying the neurodegenerative processes of multiple sclerosis (MS) and the underlying molecular mechanisms. Cognitive de-cline is widespread in MS and has a marked impact on th…
View article: Distinct expression of NEAT1 isoforms in Parkinson’s disease models suggests different roles of the variants during the disease course
Distinct expression of NEAT1 isoforms in Parkinson’s disease models suggests different roles of the variants during the disease course Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Recently long non-coding RNAs (lncRNAs) have emerged as possible molecular hubs in the diverse pathomechanisms of the disease. Among them, NEAT1 gained…
View article: Prevalence and Clinical Characteristics of the <scp> <i>LRRK2</i> </scp> p. <scp>L1795F</scp> Variant in Central Europeans with Early‐Onset and Familial Parkinson's Disease
Prevalence and Clinical Characteristics of the <span> <i>LRRK2</i> </span> p. <span>L1795F</span> Variant in Central Europeans with Early‐Onset and Familial Parkinson's Disease Open
Background Leucine‐rich repeat kinase 2 ( LRRK2 ) p.L1795F variant was proposed as a genetic risk factor for Parkinson's disease (PD). However, its prevalence, phenotype, and origin remain unknown. Objective The aim was to evaluate the fre…
View article: Expanding the Phenotypic Spectrum of <scp>SPG7</scp> Rare Damaging Variants: Insights From a Hungarian Cohort
Expanding the Phenotypic Spectrum of <span>SPG7</span> Rare Damaging Variants: Insights From a Hungarian Cohort Open
Mitochondria‐associated paraplegin dysfunction is primarily linked to spastic paraplegia; however, genetic alterations in SPG7 have been associated with a broader spectrum of clinical symptoms. To identify disease‐causing variants in the S…
View article: Thrombolysis in lacunar stroke: Comparison of early neurological improvement and 90-day functional outcome with cardioembolic stroke without large-vessel occlusion
Thrombolysis in lacunar stroke: Comparison of early neurological improvement and 90-day functional outcome with cardioembolic stroke without large-vessel occlusion Open
View article: The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals
The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals Open
View article: Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model
Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model Open
The cuprizone (CPZ) model of multiple sclerosis (MS) is excellent for studying the molecular differences behind the damage caused by poisoning. Metabolic differences in the kynurenine pathway (KP) of tryptophan (TRP) degradation are observ…
View article: Likely pathogenic variants of SDC3, KCNA2, KCNK1, KCNK16 and HSF1 are in support of acquired irreversible PIEZO2 channelopathy in ALS onset
Likely pathogenic variants of SDC3, KCNA2, KCNK1, KCNK16 and HSF1 are in support of acquired irreversible PIEZO2 channelopathy in ALS onset Open
Amyotrophic lateral sclerosis is a multisystem progressive neurodegenerative disease. A recent theory of ALS proposed that the disease initiating primary damage is an acquired irreversible intrafusal proprioceptive terminal PIEZO2 channelo…
View article: Tromboelasztográf alkalmazása szisztémás thrombolysis előtt DOAC-kal kezelt betegek esetében : esetsorozat
Tromboelasztográf alkalmazása szisztémás thrombolysis előtt DOAC-kal kezelt betegek esetében : esetsorozat Open
A direkt orális antikoagulánsokkal (DOACkal) kezelt betegek száma jelentősen nő. Akut ischaemiás stroke-ban a szisztémás thrombolysisnek jelenleg ellenjavallata a 48 órán belül alkalmazott DOAC-kezelés, ezért fontos információ a kezelés fo…
View article: ChatGPT M.D.: Is there any room for generative AI in neurology?
ChatGPT M.D.: Is there any room for generative AI in neurology? Open
ChatGPT, a general artificial intelligence, has been recognized as a powerful tool in scientific writing and programming but its use as a medical tool is largely overlooked. The general accessibility, rapid response time and comprehensive …
View article: NEDA-state, psychological symptoms and quality of life are stable in natalizumab-treated multiple sclerosis patients: An up to 6-years long follow-up study
NEDA-state, psychological symptoms and quality of life are stable in natalizumab-treated multiple sclerosis patients: An up to 6-years long follow-up study Open
View article: The effect of computerized cognitive training and transcranial direct current stimulation on working memory among post-stroke individuals: a systematic review with meta-analysis and meta-regression
The effect of computerized cognitive training and transcranial direct current stimulation on working memory among post-stroke individuals: a systematic review with meta-analysis and meta-regression Open
View article: Fatigue and depression influence the prevalence of anxiety in patients with multiple sclerosis
Fatigue and depression influence the prevalence of anxiety in patients with multiple sclerosis Open
View article: Effect of 3-nitropropionic acid on sirtuin gene expression in Sirt3 deficient mice
Effect of 3-nitropropionic acid on sirtuin gene expression in Sirt3 deficient mice Open
View article: The Application of Goal Attainment Scaling in Cervical Dystonia – An Exploratory Observational Pilot Study
The Application of Goal Attainment Scaling in Cervical Dystonia – An Exploratory Observational Pilot Study Open
Background Due to its heterogeneous manifestation an individualized approach to reach therapeutic goals in cervical dystonia (CD) is advantageous. Objectives The aim of the current study was to adapt goal attainment scaling (GAS) to drive …
View article: p.L1795F LRRK2 variant is a common cause of Parkinson’s disease in Central Europe
p.L1795F LRRK2 variant is a common cause of Parkinson’s disease in Central Europe Open
Pathogenic variants in LRRK2 are one of the most common genetic risk factors for Parkinson’s disease (PD). Recently, the lesser-known p.L1795F variant was proposed as a strong genetic risk factor for PD, however, further families are curre…
View article: The 7-year follow-up of the Hungarian BICAMS validation cohort implies that cognitive performance may improve in multiple sclerosis patients
The 7-year follow-up of the Hungarian BICAMS validation cohort implies that cognitive performance may improve in multiple sclerosis patients Open
View article: Beyond C9orf72: repeat expansions and copy number variations as risk factors of amyotrophic lateral sclerosis across various populations
Beyond C9orf72: repeat expansions and copy number variations as risk factors of amyotrophic lateral sclerosis across various populations Open
View article: A novel de novo truncating variant in a Hungarian patient with CTNNB1 neurodevelopmental disorder
A novel de novo truncating variant in a Hungarian patient with CTNNB1 neurodevelopmental disorder Open
View article: A pitvarfibrilláció és az agy
A pitvarfibrilláció és az agy Open
Az agyi érkatasztrófa, azaz a stroke amellett, hogy a második leggyakoribb halálok, az egyik leggyakoribb rokkantságot okozó kórállapot. Az esetek közel harmadában kóroki tényezőként kardiális embolizáció, a leggyakrabban pitvarfibrilláció…
View article: Examining the Prevalence of Left Atrial Appendage Thrombus in a Cohort of Acute Stroke Patients with an Extended Computed Tomography Angiographic Protocol
Examining the Prevalence of Left Atrial Appendage Thrombus in a Cohort of Acute Stroke Patients with an Extended Computed Tomography Angiographic Protocol Open
Introduction: Current guidelines recommend transthoracic echocardiography (TTE) for routine screening of cardiac emboli; however, the visualization of the left atrial appendage (LAA) where the thrombi are commonly found is po…
View article: GBA-associated Parkinson’s disease in Hungary: clinical features and genetic insights
GBA-associated Parkinson’s disease in Hungary: clinical features and genetic insights Open
Introduction Parkinson’s disease (PD) has a complex genetic background involving both rare and common genetic variants. Although a small percentage of cases show a clear Mendelian inheritance pattern, it is much more relevant to identify p…
View article: Identifying diagnostic and prognostic factors in cerebral amyloid angiopathy‐related inflammation: A systematic analysis of published and seven new cases
Identifying diagnostic and prognostic factors in cerebral amyloid angiopathy‐related inflammation: A systematic analysis of published and seven new cases Open
Aims Cerebral amyloid angiopathy (CAA)‐related inflammation (CAA‐RI) is a potentially reversible manifestation of CAA, histopathologically characterised by transmural and/or perivascular inflammatory infiltrates. We aimed to identify clini…
View article: Prediction tools and risk stratification in epilepsy surgery
Prediction tools and risk stratification in epilepsy surgery Open
Objective This study was undertaken to conduct external validation of previously published epilepsy surgery prediction tools using a large independent multicenter dataset and to assess whether these tools can stratify patients for being op…