Peter Kochunov
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View article: Heritability and shared environmental effects of brain diseases in 12,040 extended families
Heritability and shared environmental effects of brain diseases in 12,040 extended families Open
View article: st‐<scp>DenseViT</scp>: A Weakly Supervised Spatiotemporal Vision Transformer for Dense Prediction of Dynamic Brain Networks
st‐<span>DenseViT</span>: A Weakly Supervised Spatiotemporal Vision Transformer for Dense Prediction of Dynamic Brain Networks Open
Modeling dynamic neuronal activity within brain networks enables the precise tracking of rapid temporal fluctuations across different brain regions. However, current approaches in computational neuroscience fall short of capturing and repr…
View article: Normative Cerebral Perfusion Across the Lifespan
Normative Cerebral Perfusion Across the Lifespan Open
Motivation: Normative modeling offers a powerful way to understand individual differences of brain structure and function by estimating centiles for biological abnormality. Despite its potential, brain perfusion trajectories remain unexplo…
View article: aNy-way ICA and its application to estimate cortico-thalamo-cerebellar functional links in schizophrenia
aNy-way ICA and its application to estimate cortico-thalamo-cerebellar functional links in schizophrenia Open
Multimodal data collected by international and national biobanking efforts have distinct scales and model orders and provide unique and complementary insights into disease mechanisms. We propose a novel, flexible and efficient data fusion …
View article: Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis
Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis Open
Cortical brain morphology in early-onset psychosis (EOP; age of onset < 19 years) is poorly understood, partly due to recruitment constraints linked to its low incidence. We pooled T1-weighted magnetic resonance imaging (MRI) data from 387…
View article: Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI Open
Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan, complementing the process of gray matter development and degeneration. Here, we create normative lifespan reference curves for global …
View article: Adherence to life’s essential 8 is associated with delayed white matter aging
Adherence to life’s essential 8 is associated with delayed white matter aging Open
US National Institute of Health, University of Maryland, Montgomery County of Maryland.
View article: The Impact of Atlas Parcellation on Functional Connectivity Analysis Across Six Psychiatric Disorders
The Impact of Atlas Parcellation on Functional Connectivity Analysis Across Six Psychiatric Disorders Open
Neuropsychiatric disorders are associated with altered functional connectivity (FC); however, the reported regional patterns of functional alterations suffered from low replicability and high variability. This is partly because of differen…
View article: A New Multiple Imputation Method for High‐Dimensional Neuroimaging Data
A New Multiple Imputation Method for High‐Dimensional Neuroimaging Data Open
Missing data are a prevalent challenge in neuroimaging, with significant implications for downstream statistical analysis. Neglecting this issue can introduce bias and lead to erroneous inferential conclusions, making it crucial to employ …
View article: Cardiovascular comorbidities in Chinese inpatients with schizophrenia spectrum disorders
Cardiovascular comorbidities in Chinese inpatients with schizophrenia spectrum disorders Open
Cardiovascular diseases (CVDs) are the leading cause of premature mortality in patients with schizophrenia spectrum disorders (SSDs). However, the detailed categorization of these conditions remains insufficiently explored. This study aims…
View article: A prior-knowledge-guided feature selection method and its application to biomarker identification of schizophrenia
A prior-knowledge-guided feature selection method and its application to biomarker identification of schizophrenia Open
Despite considerable efforts to uncover the neural basis of psychiatric disorders using neuroimaging, few methods utilize intrinsic brain-derived knowledge, leading to limited specificity and discriminability in biomarker identification. T…
View article: Randomized Double Blind Inpatient Study of a Gluten-Free Diet in People with Schizophrenia
Randomized Double Blind Inpatient Study of a Gluten-Free Diet in People with Schizophrenia Open
View article: Randomized Double Blind Inpatient Study of a Gluten-Free Diet in People with Schizophrenia
Randomized Double Blind Inpatient Study of a Gluten-Free Diet in People with Schizophrenia Open
View article: Evidence for white matter intrinsic connectivity networks at rest and during a task: A large-scale study and templates
Evidence for white matter intrinsic connectivity networks at rest and during a task: A large-scale study and templates Open
Understanding white matter (WM) functional connectivity is crucial for unraveling brain function and dysfunction. In this study, we present a novel WM intrinsic connectivity network (ICN) template derived from over 100,000 fMRI scans, iden…
View article: Evidence for white matter intrinsic connectivity networks at rest and during a task: a large-scale study and templates
Evidence for white matter intrinsic connectivity networks at rest and during a task: a large-scale study and templates Open
Understanding white matter (WM) functional connectivity is crucial for unraveling brain function and dysfunction. In this study, we present a novel WM intrinsic connectivity network (ICN) template derived from over 100,000 fMRI scans, iden…
View article: Consistent frontal-limbic-occipital connections in distinguishing treatment-resistant and non-treatment-resistant schizophrenia
Consistent frontal-limbic-occipital connections in distinguishing treatment-resistant and non-treatment-resistant schizophrenia Open
View article: Adherence to Life’s Essential 8 is associated with delayed white matter aging
Adherence to Life’s Essential 8 is associated with delayed white matter aging Open
Importance The American Heart Association introduced Life’s Essential 8 (LE8) as a checklist of healthy lifestyle factors to help older individuals maintain and improve cardiovascular health and live longer. How LE8 can foster healthy brai…
View article: st-DenseViT: A Weakly Supervised Spatiotemporal Vision Transformer for Dense Prediction of Dynamic Brain Networks
st-DenseViT: A Weakly Supervised Spatiotemporal Vision Transformer for Dense Prediction of Dynamic Brain Networks Open
Objective: Modeling dynamic neuronal activity within brain networks enables the precise tracking of rapid temporal fluctuations across different brain regions. However, current approaches in computational neuroscience fall short of capturi…
View article: Accelerating Heritability, Genetic Correlation, and Genome‐Wide Association Imaging Genetic Analyses in Complex Pedigrees
Accelerating Heritability, Genetic Correlation, and Genome‐Wide Association Imaging Genetic Analyses in Complex Pedigrees Open
National and international biobanking efforts led to the collection of large and inclusive imaging genetics datasets that enable examination of the contribution of genetic and environmental factors to human brains in illness and health. Hi…
View article: Exploring the Granularity of the Illnesses-Related Changes in Regional Homogeneity in Major Depressive Disorder using the UKBB Data
Exploring the Granularity of the Illnesses-Related Changes in Regional Homogeneity in Major Depressive Disorder using the UKBB Data Open
Illness related brain effects of neuropsychiatric disorders are not regionally uniform, with some regions showing large pathological effects while others are relatively spared. Presently, Big Data meta-analytic studies tabulate these effec…
View article: Networks extracted from nonlinear fMRI connectivity exhibit unique spatial variation and enhanced sensitivity to differences between individuals with schizophrenia and controls
Networks extracted from nonlinear fMRI connectivity exhibit unique spatial variation and enhanced sensitivity to differences between individuals with schizophrenia and controls Open
Schizophrenia is a chronic brain disorder associated with widespread alterations in functional brain connectivity. Although data-driven approaches such as independent component analysis are often used to study how schizophrenia impacts lin…
View article: A Method for Multimodal <scp>IVA</scp> Fusion Within a <scp>MISA</scp> Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies
A Method for Multimodal <span>IVA</span> Fusion Within a <span>MISA</span> Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies Open
With the increasing availability of large‐scale multimodal neuroimaging datasets, it is necessary to develop data fusion methods which can extract cross‐modal features. A general framework, multidataset independent subspace analysis (MISA)…
View article: Imaging‐genomic spatial‐modality attentive fusion for studying neuropsychiatric disorders
Imaging‐genomic spatial‐modality attentive fusion for studying neuropsychiatric disorders Open
Multimodal learning has emerged as a powerful technique that leverages diverse data sources to enhance learning and decision‐making processes. Adapting this approach to analyzing data collected from different biological domains is intuitiv…
View article: White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals
White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals Open
View article: Author response: Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions
Author response: Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions Open
View article: A Site‐Wise Reliability Analysis of the <scp>ABCD</scp> Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms
A Site‐Wise Reliability Analysis of the <span>ABCD</span> Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms Open
The Adolescent Brain and Cognitive Development (ABCD) project is the largest study of adolescent brain development. ABCD longitudinally tracks 11,868 participants aged 9–10 years from 21 sites using standardized protocols for multi‐site MR…
View article: Increased white blood cell in young adults with family histories of alcohol and other substance use disorders
Increased white blood cell in young adults with family histories of alcohol and other substance use disorders Open
Individuals with a family history of alcohol or other substance use disorders (FH+) are at increased risk for developing alcohol and other substance use disorders (AUD/SUD) compared to individuals with no such family histories (FH−). FH+ y…
View article: Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group
Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group Open
Background Schizophrenia (SCZ) is characterized by a disconnect from reality that manifests as various clinical and cognitive symptoms, and persistent neurobiological abnormalities. Sex-related differences in clinical presentation imply se…
View article: Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions
Age-related decline in blood-brain barrier function is more pronounced in males than females in parietal and temporal regions Open
The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), and shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported in both animal and human st…
View article: Nongenetic and Genetic Factors Associated with White Matter Brain Aging: Exposome-Wide and Genome-Wide Association Study
Nongenetic and Genetic Factors Associated with White Matter Brain Aging: Exposome-Wide and Genome-Wide Association Study Open
Background/Objectives: Human brain aging is a complex process that affects various aspects of brain function and structure, increasing susceptibility to neurological and psychiatric disorders. A number of nongenetic (e.g., environmental an…