Peter Lackner
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View article: Engineering Chimeric Hypoallergens for Safer and More Effective House Dust Mite Allergy Vaccines
Engineering Chimeric Hypoallergens for Safer and More Effective House Dust Mite Allergy Vaccines Open
Summary Box Chimeric hypoallergens of Der p 1 and Blo t 1 (QBD2/QBD4) reduce IgE reactivity and airway inflammation in mice. QBD4 promotes Th1/regulatory responses, suppressing mucus and eosinophilia more effectively than QBD2.
View article: NR2F6 as a Disease Driver and Candidate Therapeutic Target in Experimental Cerebral Malaria
NR2F6 as a Disease Driver and Candidate Therapeutic Target in Experimental Cerebral Malaria Open
Cerebral malaria (CM) is the severe progression of an infection with Plasmodium falciparum, causing detrimental damage to brain tissue and is the most frequent cause of Plasmodium falciparum mortality. The critical role of brain-infiltrati…
View article: Deceptive <i>Ceropegia sandersonii</i> uses an arabinogalactan for trapping its fly pollinators
Deceptive <i>Ceropegia sandersonii</i> uses an arabinogalactan for trapping its fly pollinators Open
Summary Many plant species have evolved surfaces that reduce insect attachment. Among such plants are deceptive trap flowers of Ceropegia . Their gliding zones consist of convex epidermal cells, each with a bristle‐like central protuberanc…
View article: Transcutaneous spinal cord stimulation neuromodulates pre- and postsynaptic inhibition in the control of spinal spasticity
Transcutaneous spinal cord stimulation neuromodulates pre- and postsynaptic inhibition in the control of spinal spasticity Open
Aside from enabling voluntary control over paralyzed muscles, a key effect of spinal cord stimulation is the alleviation of spasticity. Dysfunction of spinal inhibitory circuits is considered a major cause of spasticity. These circuits are…
View article: Temporal Trends of Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis
Temporal Trends of Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis Open
Background: Intravenous thrombolysis improves functional outcome in patients with acute stroke and frequencies of r-tPA (recombinant tissue-type plasminogen activator) treatment have been increasing over time. We aimed to assess whether fu…
View article: Cerebral Malaria: Current Clinical and Immunological Aspects
Cerebral Malaria: Current Clinical and Immunological Aspects Open
This review focuses on current clinical and immunological aspects of cerebral malaria induced by Plasmodium falciparum infection. Albeit many issues concerning the inflammatory responses remain unresolved and need further investigations, c…
View article: Protein Structure Analysis and Prediction with Statistical Scoring Functions
Protein Structure Analysis and Prediction with Statistical Scoring Functions Open
The PDB database provides more than 150,000 entries for biological macromolecular structures [...]
View article: Transcutaneous Spinal Cord Stimulation Enhances Walking Performance and Reduces Spasticity in Individuals with Multiple Sclerosis
Transcutaneous Spinal Cord Stimulation Enhances Walking Performance and Reduces Spasticity in Individuals with Multiple Sclerosis Open
Gait dysfunction and spasticity are common debilitating consequences of multiple sclerosis (MS). Improvements of these motor impairments by lumbar transcutaneous spinal cord stimulation (tSCS) have been demonstrated in spinal cord injury. …
View article: Ipsi- and Contralateral Oligo- and Polysynaptic Reflexes in Humans Revealed by Low-Frequency Epidural Electrical Stimulation of the Lumbar Spinal Cord
Ipsi- and Contralateral Oligo- and Polysynaptic Reflexes in Humans Revealed by Low-Frequency Epidural Electrical Stimulation of the Lumbar Spinal Cord Open
Epidural electrical stimulation (EES) applied over the human lumbosacral spinal cord provides access to afferent fibers from virtually all lower-extremity nerves. These afferents connect to spinal networks that play a pivotal role in the c…
View article: MHCII3D—Robust Structure Based Prediction of MHC II Binding Peptides
MHCII3D—Robust Structure Based Prediction of MHC II Binding Peptides Open
Knowledge of MHC II binding peptides is highly desired in immunological research, particularly in the context of cancer, autoimmune diseases, or allergies. The most successful prediction methods are based on machine learning methods traine…
View article: Identification and Physicochemical Characterization of a New Allergen from Ascaris lumbricoides
Identification and Physicochemical Characterization of a New Allergen from Ascaris lumbricoides Open
To analyze the impact of Ascaris lumbricoides infection on the pathogenesis and diagnosis of allergic diseases, new allergens should be identified. We report the identification of a new Ascaris lumbricoides allergen, Asc l 5. The aim of th…
View article: In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization
In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization Open
Introduction: Understanding, which factors determine the immunogenicity and immune polarizing properties of proteins, is an important prerequisite for designing better vaccines and immunotherapeutics. While extrinsic immune modulatory fact…
View article: The Incidence of SARS-COV-2 Manifestations in the Central Nervous System: A Rapid Review and Meta-Analysis
The Incidence of SARS-COV-2 Manifestations in the Central Nervous System: A Rapid Review and Meta-Analysis Open
Background: Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and presents itself mainly as a respiratory tract infection. However, reports of associated central nervous system (CNS) manifestations are increasing.Methods: We cond…
View article: A hybrid of two major <i>Blomia tropicalis</i> allergens as an allergy vaccine candidate
A hybrid of two major <i>Blomia tropicalis</i> allergens as an allergy vaccine candidate Open
Introduction Allergen‐specific immunotherapy (AIT) represents a curative approach for treating allergies. In the tropical and subtropical regions of the world, Blomia tropicalis (Blo t 5 and Blo t 21) is the likely dominant source of indoo…
View article: The Cell Wall PAC (Proline-Rich, Arabinogalactan Proteins, Conserved Cysteines) Domain-Proteins Are Conserved in the Green Lineage
The Cell Wall PAC (Proline-Rich, Arabinogalactan Proteins, Conserved Cysteines) Domain-Proteins Are Conserved in the Green Lineage Open
Plant cell wall proteins play major roles during plant development and in response to environmental cues. A bioinformatic search for functional domains has allowed identifying the PAC domain (Proline-rich, Arabinogalactan proteins, conserv…
View article: In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization
In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization Open
Abstact Introduction Protein fold stability has been proposed to represent an intrinsic feature contributing to immunogenicity and immune polarization by influencing the amount of peptide-MHC II complexes (pMHCII). Using in silico predicti…
View article: Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants
Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants Open
Scope Allergies to lipid transfer proteins involve severe adverse reactions; thus, effective and sustainable therapies are desired. Previous attempts disrupting disulfide bonds failed to maintain immunogenicity; thus, the aim is to design …
View article: Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly
Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly Open
Variable phenotypic expressivity is observed for this condition, while the location and type of mutations in SZT2 also has a potential impact on epilepsy severity. These findings extend our knowledge of epileptogenic conditions related to …
Dissecting the subcellular membrane proteome reveals enrichment of H+ (co-)transporters and vesicle trafficking proteins in acidic zones of Chara internodal cells Open
The Characeae are multicellular green algae with very close relationship to land plants. Their internodal cells have been the subject of numerous (electro-)physiological studies. When exposed to light, internodal cells display alternating …
View article: Synergistic cross‐talk of hedgehog and interleukin‐6 signaling drives growth of basal cell carcinoma
Synergistic cross‐talk of hedgehog and interleukin‐6 signaling drives growth of basal cell carcinoma Open
Persistent activation of hedgehog (HH)/GLI signaling accounts for the development of basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer with rising incidence. Targeting HH/GLI signaling by approved pathway inhibitors can p…
View article: CORRECTION: Surviving murine experimental sepsis affects the function and morphology of the inner ear
CORRECTION: Surviving murine experimental sepsis affects the function and morphology of the inner ear Open
There was an error published in Biology Open 6, 732-740; doi: 10.1242/bio.024588These errors are detailed below and the original article has been changed correspondingly.The name of the co-author, Georges Hoellerich, was spelt incorrectly …
View article: Multi-Approach Analysis for the Identification of Proteases within Birch Pollen
Multi-Approach Analysis for the Identification of Proteases within Birch Pollen Open
Birch pollen allergy is highly prevalent, with up to 100 million reported cases worldwide. Proteases in such allergen sources have been suggested to contribute to primary sensitisation and exacerbation of allergic disorders. Until now the …
View article: Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen
Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen Open
Pollen is one of the most common causes of allergy worldwide, making the study of their molecular composition crucial for the advancement of allergy research. Despite substantial efforts in this field, it is not yet clear why some plant po…
View article: Brain temperature but not core temperature increases during spreading depolarizations in patients with spontaneous intracerebral hemorrhage
Brain temperature but not core temperature increases during spreading depolarizations in patients with spontaneous intracerebral hemorrhage Open
Spreading depolarizations (SDs) are highly active metabolic events, commonly occur in patients with intracerebral hemorrhage (ICH) and may be triggered by fever. We investigated the dynamics of brain-temperature (T brain ) and core-tempera…
View article: Allergens of <b><i>Blomia tropicalis</i></b>: An Overview of Recombinant Molecules
Allergens of <b><i>Blomia tropicalis</i></b>: An Overview of Recombinant Molecules Open
Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed…