Peter M. Carlton
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View article: Length-sensitive partitioning of<i>Caenorhabditis elegans</i>meiotic chromosomes senses proximity and number of crossover sites
Length-sensitive partitioning of<i>Caenorhabditis elegans</i>meiotic chromosomes senses proximity and number of crossover sites Open
Sensing and control of size is critical for cellular function and survival. A striking example of size sensing occurs during meiosis in the nematode Caenorhabditis elegans . C. elegans chromosomes compare the lengths of the two chromosome …
View article: Referee report. For: A catalogue of chromosome counts for Phylum Nematoda [version 1; peer review: 1 approved]
Referee report. For: A catalogue of chromosome counts for Phylum Nematoda [version 1; peer review: 1 approved] Open
View article: Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity
Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity Open
In the first meiotic cell division, proper segregation of chromosomes in most organisms depends on chiasmata, exchanges of continuity between homologous chromosomes that originate from the repair of programmed double-strand breaks (DSBs) c…
View article: Author response: Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity
Author response: Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In the first meiotic c…
View article: Nematode chromosomes
Nematode chromosomes Open
The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic biology, including genetics, development, cell biology, and genomics. A major factor in the success of C. elegans as a model organism has been the availabilit…
View article: Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity
Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity Open
In the first meiotic cell division, proper segregation of chromosomes in most organisms depends on chiasmata, exchanges of continuity between homologous chromosomes that originate from the repair of programmed double-strand breaks (DSBs) c…
View article: Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans
Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans Open
In the two cell divisions of meiosis, diploid genomes are reduced into complementary haploid sets through the discrete, two-step removal of chromosome cohesion, a task carried out in most eukaryotes by protecting cohesion at the centromere…
View article: Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in<i>C. elegans</i>
Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in<i>C. elegans</i> Open
In the two cell divisions of meiosis, diploid genomes are reduced into complementary haploid sets through the discrete, two-step removal of chromosome cohesion, a task carried out in most eukaryotes by protecting cohesion at the centromere…
View article: Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans
Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans Open
Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance remain largely unknown. Here, we identify the intestine-to-germl…
View article: Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes
Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes Open
Meiotic recombination is essential for faithful segregation of homologous chromosomes during gametogenesis. The progression of recombination is associated with dynamic changes in meiotic chromatin structures. However, whether Sycp2, a key …
View article: Sequential enrichment at the nuclear periphery of H2A.Zac and H3K9me2 accompanies pluripotency loss in human embryonic stem cells
Sequential enrichment at the nuclear periphery of H2A.Zac and H3K9me2 accompanies pluripotency loss in human embryonic stem cells Open
During the transition from pluripotency to a lineage-committed state, chromatin undergoes large-scale changes in structure to effect the required changes to the transcriptional program. This involves covalent modification of histone tails,…
View article: The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing
The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing Open
Germ cell immortality, or transgenerational maintenance of the germ line, could be promoted by mechanisms that could occur in either mitotic or meiotic germ cells. Here we report for the first time that the GSP-2 PP1/Glc7 phosphatase promo…
View article: The conserved phosphatase GSP-2/PP1 promotes germline immortality via small RNA-mediated genome silencing during meiosis
The conserved phosphatase GSP-2/PP1 promotes germline immortality via small RNA-mediated genome silencing during meiosis Open
Genomic silencing can promote germ cell immortality, or transgenerational maintenance of the germ line, via mechanisms that may occur during mitosis or meiosis. Here we report that the gsp-2 PP1/Glc7 phosphatase promotes germ cell immortal…
View article: Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation
Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation Open
Chromosomes that have undergone crossing over in meiotic prophase must maintain sister chromatid cohesion somewhere along their length between the first and second meiotic divisions. Although many eukaryotes use the centromere as a site to…
View article: Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation
Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation Open
Chromosomes that have undergone crossing-over in meiotic prophase must maintain sister chromatid cohesion somewhere along their length between the first and second meiotic divisions. While many eukaryotes use the centromere as a site to ma…
View article: 5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability
5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability Open
View article: Nucleosome compaction facilitates HP1γ binding to methylated H3K9
Nucleosome compaction facilitates HP1γ binding to methylated H3K9 Open
The α, β and γ isoforms of mammalian heterochromatin protein 1 (HP1) selectively bind to methylated lysine 9 of histone H3 via their chromodomains. Although the phenotypes of HP1-knockout mice are distinct for each isoform, the molecular m…
View article: Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions
Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions Open
View article: ECHO-liveFISH:<i>in vivo</i>RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues
ECHO-liveFISH:<i>in vivo</i>RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues Open
Elucidating the dynamic organization of nuclear RNA foci is important for understanding and manipulating these functional sites of gene expression in both physiological and pathological states. However, such studies have been difficult to …