Explanipedia

Euclid Structural-Thermal-Optical Performance Open

S. Serrano, G. D. Racca, Vincenzo Mareschi, C. Baccigalupi, A. Balestra , et al. · 2025

The Euclid system performance is defined in terms of image quality metrics tuned to the weak gravitational lensing (WL) cosmological probe. WL induces stringent requirements on the shape and stability of the VIS instrument system point spr…

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors Open

Julie George, Vonn Walter, Martin Peifer, Ludmil B. Alexandrov, Danila Seidel , et al. · 2025

UYSD: a novel data repository accessible via public website for worldwide population frequencies of Y-SNP haplogroups Open

Arwin Ralf, Dion Zandstra, Bram van Wersch, Zehra Köksal, Maarten Larmuseau , et al. · 2025

For decades, there has been scientific interest in the variation and geographic distribution of paternal lineages associated with the human Y chromosome. However, the relevant data have been dispersed across numerous publications, making i…

Macroepidemiological trends of Influenza A virus detection through reverse transcription real-time polymerase chain reaction (RT-rtPCR) in porcine samples in the United States over the last 20 years Open

D. C. A. Moraes, Guilherme Cezar, Edison Magalhaes, Rafael Romero Nicolino, Kinath Rupasinghe , et al. · 2025

Influenza A virus (IAV) in swine is a major respiratory pathogen with global significance. This study aimed to characterize the macroepidemiological patterns of IAV detection using reverse transcription real-time polymerase chain reaction …

Harnessing sequencing data for porcine reproductive and respiratory syndrome virus (PRRSV): tracking genetic evolution dynamics and emerging sequences in US swine industry Open

Srijita Chandra, Guilherme Cezar, Kinath Rupasinghe, Edison Magalhães, Gustavo S. Silva , et al. · 2025

Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important swine pathogen affecting the United States of America (USA), leading to significant economic losses. Despite advances in diagnostic testing, there remains a …

Collaborative exercise: analysis of age estimation using a QIAGEN protocol and the PyroMark Q48 platform Open

Marie‐Louise Kampmann, Jan Fleckhaus, Claus Børsting, Helena Jurtikova, Alice Piters , et al. · 2024

Human age estimation from trace samples may give important leads early in a police investigation by contributing to the description of the perpetrator. Several molecular biomarkers are available for the estimation of chronological age, and…

Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on short tandem repeat sequence nomenclature Open

Katherine B. Gettings, Martin Bodner, Lisa A. Borsuk, Jonathan L. King, David Ballard , et al. · 2023

The DNA Commission of the International Society for Forensic Genetics (ISFG) has developed a set of nomenclature recommendations for short tandem repeat (STR) sequences. These recommendations follow the 2016 considerations of the DNA Commi…

Development and evaluations of the ancestry informative markers of the VISAGE Enhanced Tool for Appearance and Ancestry Open

Jorge Ruiz-Ramírez, M. de la Puente, Catarina Xavier, A. Ambroa-Conde, José Antonio Álvarez‐Dios , et al. · 2023

Einsatz vollkontinuierlicher Modelle zur biostatistischen Bewertung forensischer DNA-analytischer Befunde Open

Michael V. Templin, Peter Zimmermann, Sebastian Kranz, Martin Eckert, Christoph Leuker , et al. · 2023

Zusammenfassung Die biostatistische Bewertung DNA-analytischer Befunde unterstützt Gerichte bei der Einschätzung des Beweiswertes einer Spur. In der Praxis werden dabei zunehmend Spuren mit minimaler DNA-Menge und möglichen „Drop-in“- und …

Supplementary Material for: Graphic Intelligent Diagnosis of Hypoxic-Ischemic Encephalopathy Using MRI-Based Deep Learning Model Open

Natalie Weiler, Peter M. Schneider, Christopher Phillips, Wojciech Branicki, Valerie van den Eertwegh , et al. · 2023

Introduction: Heterogeneous MRI manifestations restrict the efficiency and consistency of neuroradiologists in diagnosing hypoxic-ischemic encephalopathy (HIE) due to complex injury patterns. This study aimed to develop and v…

Gemeinsame Empfehlungen der Projektgruppe „Biostatistische DNA-Berechnungen“ und der Spurenkommission zur biostatistischen Bewertung forensischer DNA-analytischer Befunde mit vollkontinuierlichen Modellen (VKM) Open

Meinhard Hahn, Katja Anslinger, Martin Eckert, Rolf Fimmers, Stefanie Grethe , et al. · 2022

Zusammenfassung Die biostatistische Bewertung DNA-analytischer Befunde unterstützt Gerichte bei der Einschätzung des Beweiswertes hinsichtlich einer möglichen Spurenbeteiligung durch eine zu betrachtende Person (engl. „Person Of Interest“;…

Development and inter-laboratory evaluation of the VISAGE Enhanced Tool for Appearance and Ancestry inference from DNA Open

Catarina Xavier, M. de la Puente, Ana Mosquera‐Miguel, A. Freire-Aradas, Vivian Kalamara , et al. · 2022

Responding to the growing scientific and practical interest in forensic DNA phenotyping, the VISible Attributes through GEnomics (VISAGE) Consortium was founded in 2017 with the main goal of developing and validating new and reliable molec…

Publisher Erratum: Möglichkeiten und Grenzen der forensischen DNA-Analyse unter dem Gesichtspunkt verschiedener Szenarien zur Spurenentstehung Open

Marielle Vennemann, Claus Oppelt, Stefanie Grethe, Katja Anslinger, Rolf Fimmers , et al. · 2022

The effect of TGF-β1 polymorphisms on pulmonary disease progression in patients with cystic fibrosis Open

Tobias Trojan, Miguel A. Alejandre Alcázar, Gregor Fink, Jan C. Thomassen, Maxine von Maessenhausen , et al. · 2022

Background Transforming Growth Factor-β 1 (TGF-β 1 ) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β 1 are associated with neutrophilic inflammation, lung fibrosis and lo…

The effect of TGF-beta1 polymorphisms on pulmonary disease progression in patients with cystic fibrosis Open

Tobias Trojan, Miguel A. Alejandre Alcázar, Gregor Fink, Jan C. Thomassen, Maxine von Maessenhausen , et al. · 2022

Background: Transforming Growth Factor-b 1 (TGF-b 1 ) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-b 1 are associated with neutrophilic inflammation, lung fibrosis und l…

Variant interpretation in molecular autopsy: a useful dilemma Open

Stefanie Scheiper-Welling, Monika Tabunscik, T.E. Gross, Tina Jenewein, Britt Maria Beckmann , et al. · 2022

Full electrification opportunities of spray dryers in milk powder processes Open

Jierong Liang, Martin Pihl Andersen, Roger Padullés, Lorenzo Bellemo, Riccardo Bergamini , et al. · 2022

A collaborative exercise on DNA methylation-based age prediction and body fluid typing Open

Ji Eun Lee, Jeong Min Lee, Jana Naue, Jan Fleckhaus, A. Freire-Aradas , et al. · 2021

Schwere sexualisierte Gewalt – Aufklärung eines Falls durch Kombination aus DNA- und mRNA-Analyse Open

Maximilian Neis, Sonja Siegel, Sibylle Banaschak, Peter M. Schneider · 2021

Zusammenfassung Mithilfe der Analyse von mRNA-Expressionsmustern durch Einsatz der PCR-Amplifikation von zellspezifischen cDNA-Transkripten und Nachweis der Amplifikate mittels Kapillarelektrophorese (CE) lässt sich die Frage klären, aus w…

The Effect of TGF-beta-1 Polymorphisms on Pulmonary Disease Progression in Patients with Cystic Fibrosis Open

Tobias Trojan, Miguel A. Alejandre Alcázar, Gregor Fink, Jan C. Thomassen, Maxine von Maessenhausen , et al. · 2021

Background: Transforming Growth Factor-b 1 (TGF-b 1 ) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-b 1 are associated with neutrophilic inflammation, lung fibrosis und l…

Development and Evaluation of the Ancestry Informative Marker Panel of the VISAGE Basic Tool Open

M. de la Puente, Jorge Ruiz-Ramírez, A. Ambroa-Conde, Catarina Xavier, Jacobo Pardo‐Seco , et al. · 2021

We detail the development of the ancestry informative single nucleotide polymorphisms (SNPs) panel forming part of the VISAGE Basic Tool (BT), which combines 41 appearance predictive SNPs and 112 ancestry predictive SNPs (three SNPs shared…

Möglichkeiten und Grenzen der forensischen DNA-Analyse unter dem Gesichtspunkt verschiedener Szenarien zur Spurenentstehung Open

Marielle Vennemann, Claus Oppelt, Stefanie Grethe, Katja Anslinger, Rolf Fimmers , et al. · 2021

The Effect of TGF-β1 Polymorphisms on Pulmonary Disease Progression in Patients with Cystic Fibrosis Open

Tobias Trojan, Maxine von Maessenhausen, Peter M. Schneider, Gregor Fink, Ernst Rietschel , et al. · 2021

Background : Transforming Growth Factor-β 1 (TGF-β 1 ) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β 1 are associated with neutrophilic inflammation, lung fibrosis und …

Forensische DNA-Methylierungsanalyse Open

Olivia Holländer, Kristina Schwender, Petra Böhme, Jan Fleckhaus, Cordula Haas , et al. · 2021

Forensische DNA-Methylierungsanalyse Open

Jana Naue, Manuel Pfeifer, Christa Augustin, Julia C. Becker, Jan Fleckhaus , et al. · 2021

Progress in the implementation of massively parallel sequencing for forensic genetics: results of a European-wide survey among professional users Open

T.E. Gross, Jan Fleckhaus, Peter M. Schneider · 2021

Measurements of the Ultraviolet Spectral Characteristics of Low-mass Exoplanetary Systems (Mega- MUSCLES) Open

David J. Wilson, Cynthia S. Froning, Allison Youngblood, Girish M. Duvvuri, Alexander Brown , et al. · 2021

mRNA profiling of mock casework samples: Results of a FoRNAP collaborative exercise Open

Andrea Patrizia Salzmann, Malte Bamberg, Cornelius Courts, Guro Dørum, Annica Gosch , et al. · 2020

In recent years, forensic mRNA profiling has increasingly been used to identify the origin of human body fluids. By now, several laboratories have implemented mRNA profiling and also use it in criminal casework. In 2018 the FoRNAP (Forensi…

Pyrosequenzierung zur molekularen Altersschätzung in der DNA-Spurenanalyse Open

Jan Fleckhaus, Peter M. Schneider · 2020

The estimation of the chronological age based on DNA methylation markers by bisulfite sequencing is a promising new method in forensic molecular genetics. The application of the method to forensic trace samples from crime scenes was recent…

Development and validation of the VISAGE AmpliSeq basic tool to predict appearance and ancestry from DNA Open

Catarina Xavier, M. de la Puente, Ana Mosquera‐Miguel, A. Freire-Aradas, Vivian Kalamara , et al. · 2020

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