Peter Marhofer
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View article: Intestinal Reconstruction in Infants Under Epidural Anesthesia Without Invasive Airway: A Prospective Case Study
Intestinal Reconstruction in Infants Under Epidural Anesthesia Without Invasive Airway: A Prospective Case Study Open
Background and Aims: This study explored the feasibility of performing intestinal reconstruction after enterostomy in infants using ultrasound-guided epidural anesthesia with sedation, aiming to avoid invasive airway manipulation and the u…
View article: Pediatric Regional Anesthesia: A Practical Guideline for Daily Clinical Practice
Pediatric Regional Anesthesia: A Practical Guideline for Daily Clinical Practice Open
The past two decades have seen remarkable progress in pediatric regional anesthesia. Significant efforts have been made to develop central and peripheral techniques that are both practicable and reliable, with increasing success and very l…
View article: Cerebrospinal fluid concentrations of ceftaroline and ceftazidime/avibactam in healthy volunteers: Pharmacokinetics and probability of target attainment
Cerebrospinal fluid concentrations of ceftaroline and ceftazidime/avibactam in healthy volunteers: Pharmacokinetics and probability of target attainment Open
In healthy subjects, ceftaroline, ceftazidime and avibactam poorly distribute to CSF. Nonetheless, CSF exposure of both cephalosporins might be sufficient to cover certain, but not all, pathogens causative of CNS infections.
View article: Virtual Reality-Assisted Informed Consent for Anesthesia: A Prospective and Randomized Proof-of-Concept Study
Virtual Reality-Assisted Informed Consent for Anesthesia: A Prospective and Randomized Proof-of-Concept Study Open
Background/Objectives: Informed consent for anesthesia poses both legal challenges and problems of understandable communication. Fulfilling all the requirements through anesthesiologists directly interacting with patients is a time- and st…
View article: Virtual Reality-Assisted Informed Consent for Anesthesia: A Prospective and Randomized Proof-of-Concept Study
Virtual Reality-Assisted Informed Consent for Anesthesia: A Prospective and Randomized Proof-of-Concept Study Open
Background/Objectives: Informed consent for anesthesia poses both legal challenges and problems of understandable communication. Fulfilling all requirements through anesthesiologists directly interacting with patients is a time- and staff-…
View article: Liposomal Bupivacaine for Peripheral Nerve Blockade: A Randomized, Controlled, Crossover, Triple-blinded Pharmacodynamic Study in Volunteers
Liposomal Bupivacaine for Peripheral Nerve Blockade: A Randomized, Controlled, Crossover, Triple-blinded Pharmacodynamic Study in Volunteers Open
Background Little is known about the pharmacodynamic characteristics of liposomal bupivacaine. Hypothesizing that they would not identify pharmacodynamic differences from plain bupivacaine during the initial period after administration, bu…
View article: The impact of biological sex in peripheral nerve blockade: A prospective pharmacodynamic, pharmacokinetic and morphometric study in volunteers
The impact of biological sex in peripheral nerve blockade: A prospective pharmacodynamic, pharmacokinetic and morphometric study in volunteers Open
Study objective The impact of biological sex in peripheral regional anaesthesia is largely unknown. We therefore designed a prospective study in volunteers to investigate the impact of biological sex on pharmacodynamic, pharmacokinetic and…
View article: Ultrasound-Guided Dorsal Penile Nerve Block in Children: An Anatomical-Based Observational Study of a New Anesthesia Technique
Ultrasound-Guided Dorsal Penile Nerve Block in Children: An Anatomical-Based Observational Study of a New Anesthesia Technique Open
Dorsal penile nerve block stands out as one of the commonly employed regional anesthetic techniques in children. Despite the large body of experience, failure rates are still significant. We included 20 children (median (SD) age of 73 (31)…
View article: Accuracy of a Dual-Sensor Heat-Flux (DHF) Non-Invasive Core Temperature Sensor in Pediatric Patients Undergoing Surgery
Accuracy of a Dual-Sensor Heat-Flux (DHF) Non-Invasive Core Temperature Sensor in Pediatric Patients Undergoing Surgery Open
Accurate temperature measurement is crucial for the perioperative management of pediatric patients, and non-invasive thermometry is necessary when invasive methods are infeasible. A prospective observational study was conducted on 57 patie…
View article: A radiological cadaveric study of obturator nerve involvement and cranial injectate spread after different approaches to the fascia iliaca compartment block
A radiological cadaveric study of obturator nerve involvement and cranial injectate spread after different approaches to the fascia iliaca compartment block Open
Whether the fascia iliaca compartment block (FICB) involves the obturator nerve (ON) remains controversial. Involvement may require that the injectate spreads deep in the cranial direction, and might thus depend on the site of injection. T…
View article: Sex differences in pediatric caudal epidural anesthesia under sedation without primary airway instrumentation
Sex differences in pediatric caudal epidural anesthesia under sedation without primary airway instrumentation Open
Study objective To identify sex differences associated with caudal epidurals, the most commonly used technique of pediatric regional anesthesia, based on individually validated data of ultrasound-guided blocks performed between 04/2014 and…
View article: Regional anaesthesia practices: insights from a European survey
Regional anaesthesia practices: insights from a European survey Open
BACKGROUND The use of regional anaesthesia has increased and evolved over the past two decades but to what extent is unclear. Moreover, there is no clear standardisation of best practice in the current European landscape, which could resul…
View article: ADV6209 for Premedication in Pediatric Anesthesia: A Double-Blinded, Randomized Controlled Trial
ADV6209 for Premedication in Pediatric Anesthesia: A Double-Blinded, Randomized Controlled Trial Open
ADV6209, a new formulation of midazolam with the addition of γ-cyclodextrin for oral use, has recently been licensed as the first pediatric sedative in the European Union. We compared the clinical efficacy of ADV6209 to the standard formul…
View article: Ad-hoc preoperative management and respiratory events in pediatric anesthesia during the first COVID-19 lockdown–an observational cohort study
Ad-hoc preoperative management and respiratory events in pediatric anesthesia during the first COVID-19 lockdown–an observational cohort study Open
Background Early pre-anesthetic management for surgery is aimed at identifying risk factors, which notably in children are mostly airway related. The first COVID-19 lockdown opened a unique ‘window of opportunity’ to study what impact an a…
View article: Ultrasound‐guided caudal blockade and sedation for paediatric surgery: a retrospective cohort study
Ultrasound‐guided caudal blockade and sedation for paediatric surgery: a retrospective cohort study Open
Summary Data on safety and success rates of ultrasound‐guided caudal blockade, performed on sedated children with an uninstrumented airway, are scarce. We performed a retrospective observational study of validated data from April 2014 to D…
View article: A prospective observational study on the feasibility of subumbilical laparoscopic procedures under epidural anesthesia in sedated spontaneously breathing infants with a natural airway
A prospective observational study on the feasibility of subumbilical laparoscopic procedures under epidural anesthesia in sedated spontaneously breathing infants with a natural airway Open
Background Laparoscopic procedures are usually performed under general anesthesia with a secured airway including endotracheal intubation or supraglottic airways. Aims This is a prospective study of the feasibility of subumbilical laparosc…
View article: Proximal Perineural Femoral Nerve Injection in Pigs Using an Ultrasound-Guided Lateral Subiliac Approach—A Cadaveric Study
Proximal Perineural Femoral Nerve Injection in Pigs Using an Ultrasound-Guided Lateral Subiliac Approach—A Cadaveric Study Open
Desensitizing the femoral nerve (FN) improves pain control in several species undergoing pelvic limb surgeries. Despite its advantages, this method has not yet been described in pigs, although they make an accepted surgical animal model. B…
View article: Epidural versus general anesthesia for open pyloromyotomy in infants: A retrospective observational study
Epidural versus general anesthesia for open pyloromyotomy in infants: A retrospective observational study Open
Background Thoracic epidural anesthesia for open infantile hypertrophic pyloric stenosis surgery is a controversial issue in the presence of little comparative data. Aims To compare this approach to general anesthesia for desaturation even…
View article: Ultrasound-guided epidural anesthesia and sedation foropen abdominal surgery in 20 consecutive children:a prospective case series and proof-of-concept study
Ultrasound-guided epidural anesthesia and sedation foropen abdominal surgery in 20 consecutive children:a prospective case series and proof-of-concept study Open
General anesthesia (GA) in children is associated with respiratory events and a potential for drug-induced neurotoxicity. Aiming to reduce airway manipulation and the use of GA drugs, we designed a study of abdominal surgery under epidural…
View article: Implementation of Electrical Auricular Acupuncture and Low Frequency Modulated Electric Current Therapy in Pain Management of Patients with Knee Osteoarthritis: A Randomized Pilot Trial
Implementation of Electrical Auricular Acupuncture and Low Frequency Modulated Electric Current Therapy in Pain Management of Patients with Knee Osteoarthritis: A Randomized Pilot Trial Open
Background: Knee osteoarthritis is a major cause of knee pain. Conservative therapy resources are limited due to adverse effects. Therefore, alternative non-invasive therapy approaches to reduce pain medications are gaining importance. The…
View article: Dexamethasone in regional anaesthesia: travelling up a blind alley?
Dexamethasone in regional anaesthesia: travelling up a blind alley? Open
The use of dexamethasone, administered either systemically or perineurally, as an adjunct to peripheral or neuraxial regional blocks, is currently one of the hottest topics in the field of regional anaesthesia. A large number of clinical s…