Peter Mastrangelo
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View article: A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins
A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins Open
How the cuticles of the roughly 4.5 million species of ecdysozoan animals are constructed is not well understood. Here, we systematically mine gene expression datasets to uncover the spatiotemporal blueprint for how the chitin-based pharyn…
View article: Author response: A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins
Author response: A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins Open
View article: A Spatiotemporal Reconstruction of the <i>C. elegans</i> Pharyngeal Cuticle Reveals a Structure Rich in Phase-Separating Proteins
A Spatiotemporal Reconstruction of the <i>C. elegans</i> Pharyngeal Cuticle Reveals a Structure Rich in Phase-Separating Proteins Open
Roughly 4.5 million species of ecdysozoan animals repeatedly shed their old cuticle and construct a new one underneath to accommodate growth. How cuticles are constructed is not well understood. Here, we systematically mine gene expression…
View article: Identification of RSV Fusion Protein Interaction Domains on the Virus Receptor, Nucleolin
Identification of RSV Fusion Protein Interaction Domains on the Virus Receptor, Nucleolin Open
Nucleolin is an essential cellular receptor to human respiratory syncytial virus (RSV). Pharmacological targeting of the nucleolin RNA binding domain RBD1,2 can inhibit RSV infections in vitro and in vivo; however, the site(s) on RBD1,2 wh…
View article: Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection Open
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children. Currently, there is no RSV vaccine or universally accessible antiviral treatment available. Addressing the urgent need fo…
View article: Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities
Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities Open
Nucleolin (NCL) has been reported as a cellular receptor for the human respiratory syncytial virus (RSV). We studied the effects of re-purposing AS1411, an anti-cancer compound that binds cell surface NCL, as a possible novel strategy for …