Matt P. Wise
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View article: Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest: insights from the TTM2-trial
Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest: insights from the TTM2-trial Open
NCT02908308.
View article: The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study
The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study Open
This analysis found that the cost-effectiveness of mild hypercapnia is highly uncertain when compared with normocapnia in adult patients following OHCA, with no significant differences in either costs or outcomes. Further research is requi…
View article: Timing of pharmacological thromboprophylaxis following traumatic brain injury: a UK-wide survey of clinical practice
Timing of pharmacological thromboprophylaxis following traumatic brain injury: a UK-wide survey of clinical practice Open
This study underscores the lack of consensus for VTE prophylaxis in TBI patients. There is a pressing need for a randomised control trial to guide the optimal timing of PTP following TBI to improve patient care.
View article: Long‐Term Outcomes After Cardiac Arrest: Protocol for the Extended Follow‐Up Sub‐Study of the <scp>STEPCARE</scp> Trial
Long‐Term Outcomes After Cardiac Arrest: Protocol for the Extended Follow‐Up Sub‐Study of the <span>STEPCARE</span> Trial Open
Background The international multi‐center randomized controlled STEPCARE‐trial will investigate optimal management of sedation, temperature, and mean arterial pressure (MAP) during intensive care in out‐of‐hospital cardiac arrest (OHCA) pa…
View article: Protocolized <scp>REDUction</scp> of Non‐Resuscitation Fluids in <scp>SEptic</scp> Shock Patients. A Protocol for the <scp>REDUSE</scp> Randomized Clinical Trial
Protocolized <span>REDUction</span> of Non‐Resuscitation Fluids in <span>SEptic</span> Shock Patients. A Protocol for the <span>REDUSE</span> Randomized Clinical Trial Open
In septic shock, administration of large fluid volumes is associated with poor outcomes. Recent evidence shows that non‐resuscitation fluids are the major modifiable source of fluids for patients with septic shock in intensive care units (…
View article: V-CARE (Virtual Care After REsuscitation): Protocol for a Randomized Feasibility Study of a Virtual Psychoeducational Intervention After Cardiac Arrest—A STEPCARE Sub-Study
V-CARE (Virtual Care After REsuscitation): Protocol for a Randomized Feasibility Study of a Virtual Psychoeducational Intervention After Cardiac Arrest—A STEPCARE Sub-Study Open
Background: Out-of-hospital cardiac arrest (OHCA) survivors and their relatives may face challenges following hospital discharge, relating to mood, cognition, and returning to normal day-to-day activities. Identified research gaps include …
View article: Radiological signs of hypoxic-ischaemic encephalopathy on head computed tomography for prediction of poor functional outcome after cardiac arrest – a prospective observational cohort study
Radiological signs of hypoxic-ischaemic encephalopathy on head computed tomography for prediction of poor functional outcome after cardiac arrest – a prospective observational cohort study Open
Extensive and bilateral loss of grey-white matter distinction on CT is associated with poor functional outcome after cardiac arrest and yielded the highest interrater agreement. Signs of sulcal effacement were less reliable and should thus…
View article: Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (<scp>MAP</scp>‐<scp>CARE</scp>): A protocol for a randomized clinical trial
Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (<span>MAP</span>‐<span>CARE</span>): A protocol for a randomized clinical trial Open
Background In patients resuscitated after cardiac arrest, a higher mean arterial pressure (MAP) may increase cerebral perfusion and attenuate hypoxic brain injury. Here we present the protocol of the mean arterial pressure after cardiac ar…
View article: Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial
Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial Open
Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, …
View article: Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (<scp>TEMP</scp>‐<scp>CARE</scp>): A study protocol for a randomized clinical trial
Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (<span>TEMP</span>‐<span>CARE</span>): A study protocol for a randomized clinical trial Open
Background Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback‐controlled device impacts patient‐centered outcomes in cardiac arrest patients. This trial aims to investigate fe…
View article: Sedation, temperature and pressure after cardiac arrest and resuscitation—The <scp>STEPCARE</scp> trial: A statistical analysis plan
Sedation, temperature and pressure after cardiac arrest and resuscitation—The <span>STEPCARE</span> trial: A statistical analysis plan Open
Background Basic management for patients who have suffered a cardiac arrest and are admitted to an intensive care unit (ICU) after resuscitation includes setting targets for blood pressure and managing sedation and temperature. However, op…
View article: Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (<scp>SED</scp>‐<scp>CARE</scp>): A protocol for a randomized clinical trial
Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (<span>SED</span>‐<span>CARE</span>): A protocol for a randomized clinical trial Open
Background Sedation is often provided to resuscitated out‐of‐hospital cardiac arrest (OHCA) patients to tolerate post‐cardiac arrest care, including temperature management. However, the evidence of benefit or harm from routinely administer…
View article: Comparison of self-reported physical activity between survivors of out-of-hospital cardiac arrest and patients with myocardial infarction without cardiac arrest: a case–control study
Comparison of self-reported physical activity between survivors of out-of-hospital cardiac arrest and patients with myocardial infarction without cardiac arrest: a case–control study Open
Aims To investigate whether out-of-hospital cardiac arrest (OHCA) survivors had lower levels of self-reported physical activity compared to a non-cardiac arrest control group with myocardial infarction (MI), and to explore if symptoms of a…
View article: A Core Outcome Set for Adult General ICU Patients
A Core Outcome Set for Adult General ICU Patients Open
OBJECTIVES: Randomized clinical trials informing clinical practice (e.g., like large, pragmatic, and late-phase trials) should ideally mostly use harmonized outcomes that are important to patients, family members, clinicians, and researche…
View article: Effects of very early hyperoxemia on neurologic outcome after out-of-hospital cardiac arrest: A secondary analysis of the TTM-2 trial
Effects of very early hyperoxemia on neurologic outcome after out-of-hospital cardiac arrest: A secondary analysis of the TTM-2 trial Open
Very early hyperoxemia after ICU admission is associated with higher risk of poor functional outcome after OHCA. Avoiding hyperoxia in the initial hours after resuscitation should be considered.
View article: Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study
Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study Open
In this study, hypothermia at 33˚C did not improve survival or functional outcome in a subset of patients with similar cardiac arrest characteristics to patients in whom benefit from hypothermia was shown in prior studies.
View article: Combined use of the Montreal Cognitive Assessment and Symbol Digit Modalities Test improves neurocognitive screening accuracy after cardiac arrest: A validation sub-study of the TTM2 trial
Combined use of the Montreal Cognitive Assessment and Symbol Digit Modalities Test improves neurocognitive screening accuracy after cardiac arrest: A validation sub-study of the TTM2 trial Open
gov Identifier: NCT03543371.
View article: Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study
Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study Open
Standardised qualitative and quantitative assessments of CT are reliable and feasible methods to predict poor functional outcome after cardiac arrest. Automated GWR has the potential to make CT quantification for neuroprognostication acces…
View article: Desmopressin for prevention of bleeding for thrombocytopenic, critically ill patients undergoing invasive procedures: A randomised, double‐blind, placebo‐controlled feasibility trial
Desmopressin for prevention of bleeding for thrombocytopenic, critically ill patients undergoing invasive procedures: A randomised, double‐blind, placebo‐controlled feasibility trial Open
Thrombocytopenic patients have an increased risk of bleeding when undergoing invasive procedures. In a multicentre, phase II, blinded, randomised, controlled feasibility trial, critically ill patients with platelet count 100 × 10 9 /L or l…
View article: Associations between enteral nutrition and outcomes in the <scp>SUP</scp>‐<scp>ICU</scp> trial: Results of exploratory post hoc analyses
Associations between enteral nutrition and outcomes in the <span>SUP</span>‐<span>ICU</span> trial: Results of exploratory post hoc analyses Open
Background Enteral nutrition may affect risks of gastrointestinal bleeding, pneumonia and mortality in critically ill patients and may also modify the effects of pharmacological stress ulcer prophylaxis. We undertook post hoc analyses of t…
View article: A core outcome set for adult general ICU patients
A core outcome set for adult general ICU patients Open
Purpose Randomised clinical trials should ideally use harmonised outcomes that are important to patients and to facilitate meta-analyses and ensuring generalisability. Core outcome sets for specific subsets of ICU patients exist, e.g., res…
View article: Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial
Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial Open
Introduction An association between deep sedation and adverse short-term outcomes has been demonstrated although this evidence has been inconsistent. The A2B (alpha-2 agonists for sedation in critical care) sedation trial is designed to de…
View article: Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19
Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19 Open
Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting a Pa o 2 of 60 mm Hg vs 90 mm Hg in patients with COVID-19…