Peter Micallef
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View article: Detecting <scp> <i>TP53</i> </scp> mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma
Detecting <span> <i>TP53</i> </span> mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma Open
High‐grade serous ovarian carcinoma (HGSC) is the most lethal form of ovarian carcinoma, often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study aimed to devel…
View article: Digital sequencing is improved by using structured unique molecular identifiers
Digital sequencing is improved by using structured unique molecular identifiers Open
Digital sequencing uses unique molecular identifiers (UMIs) to correct for polymerase induced errors and amplification biases. Here, we design 19 different structured UMIs to minimize the capacity of primers to form non-specific PCR produc…
View article: C1QTNF3 is Upregulated During Subcutaneous Adipose Tissue Remodeling and Stimulates Macrophage Chemotaxis and M1-Like Polarization
C1QTNF3 is Upregulated During Subcutaneous Adipose Tissue Remodeling and Stimulates Macrophage Chemotaxis and M1-Like Polarization Open
The adipose tissue undergoes substantial tissue remodeling during weight gain-induced expansion as well as in response to the mechanical and immunological stresses from a growing tumor. We identified the C1q/TNF-related protein family memb…
View article: Adipose Tissue—Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor Growth
Adipose Tissue—Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor Growth Open
We sought to identify therapeutic targets for breast cancer by investigating the metabolic symbiosis between breast cancer and adipose tissue. To this end, we compared orthotopic E0771 breast cancer tumors that were in direct contact with …
View article: Maternal adiponectin prevents visceral adiposity and adipocyte hypertrophy in prenatal androgenized female mice
Maternal adiponectin prevents visceral adiposity and adipocyte hypertrophy in prenatal androgenized female mice Open
Hyperandrogenism is the main characteristic of polycystic ovary syndrome, which affects placental function and fetal growth, and leads to reproductive and metabolic dysfunction in female offspring. Adiponectin acts on the placenta and may …
View article: Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes
Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes Open
β-Adrenergic stimulation of adipose tissue increases mitochondrial density and activity (browning) that are associated with improved whole-body metabolism. Whereas chronically elevated levels of reactive oxygen species (ROS) in adipose tis…
View article: Adiponectin protects against development of metabolic disturbances in a PCOS mouse model
Adiponectin protects against development of metabolic disturbances in a PCOS mouse model Open
Significance Women with polycystic ovary syndrome (PCOS) have reduced fertility and increased risk of developing type 2 diabetes. Adiponectin, an adipocyte-derived hormone, together with adipocyte size, is the strongest factor associated w…
View article: CNS β<sub>3</sub>-adrenergic receptor activation regulates feeding behavior, white fat browning, and body weight
CNS β<sub>3</sub>-adrenergic receptor activation regulates feeding behavior, white fat browning, and body weight Open
Pharmacological β 3 -adrenergic receptor (β 3 AR) activation leads to increased mitochondrial biogenesis and activity in white adipose tissue (WAT), a process commonly referred to as “browning”, and transiently increased insulin release. T…