Peter M.K. Westcott
YOU?
Author Swipe
View article: Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis
Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis Open
Necrosis, conventionally thought of as a passive consequence of aggressive tumor growth, is associated with poor prognosis in colorectal cancer (CRC). We recently discovered that necrosis can be caused by neutrophils and neutrophil extrace…
View article: Small molecule modulators of TOX protein re-invigorate T cell activity
Small molecule modulators of TOX protein re-invigorate T cell activity Open
The TOX protein (thymocyte selection-associated high mobility group box) is a critical transcription factor implicated in both T acute lymphoblastic leukemia (T-ALL) and CD8 + T cell exhaustion. Gene perturbation studies suggest that inhib…
View article: The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1 Open
Lineage plasticity is a hallmark of cancer progression that impacts therapy outcomes, yet the mechanisms mediating this process remain unclear. Here, we introduce a versatile in vivo platform to interrogate neuroendocrine lineage transform…
View article: The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1 Open
Lineage plasticity is a recognized hallmark of cancer progression that can shape therapy outcomes. The underlying cellular and molecular mechanisms mediating lineage plasticity remain poorly understood. Here, we describe a versatile in viv…
View article: SOX17 enables immune evasion of early colorectal adenomas and cancers
SOX17 enables immune evasion of early colorectal adenomas and cancers Open
View article: 21 Increased mutation burden alone is not sufficient to increase immunogenicity of DNA mismatch repair deficient tumors
21 Increased mutation burden alone is not sufficient to increase immunogenicity of DNA mismatch repair deficient tumors Open
Background DNA mismatch repair deficiency (MMRd) drives the accumulation of somatic mutation-derived antigens (neoantigens), which underlies the remarkable response rates of this class of cancer to immune checkpoint blockade (ICB) therapy.…
View article: Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity Open
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most MMRd tumors do not durably respond to ICB and critical questions …
View article: A prime editor mouse to model a broad spectrum of somatic mutations in vivo
A prime editor mouse to model a broad spectrum of somatic mutations in vivo Open
View article: Microbial regulation of anti-tumor immunity in colorectal cancer
Microbial regulation of anti-tumor immunity in colorectal cancer Open
Colorectal cancer (CRC) is one of the most common and deadly types of cancer. Although recent advances in early detection and revolutionary therapies such as checkpoint blockade immunotherapy resulted in improved outcomes in CRC, a large f…
View article: RNA-seq (cell line) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
RNA-seq (cell line) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for bulk RNA-seq of isogenic SMARCA4-WT and -KO cell lines
View article: Supplementary Figures S1-S7 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Supplementary Figures S1-S7 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Supplementary Figures related to Figures 1-6
View article: CUT&RUN Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
CUT&RUN Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for CUT&RUN of isogenic SMARCA4-WT and -KO cell lines
View article: Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung adenocarcinoma. However, the functional consequences of SMA…
View article: RNA-seq (cell line) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
RNA-seq (cell line) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for bulk RNA-seq of isogenic SMARCA4-WT and -KO cell lines
View article: Bulk ATAC-seq Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Bulk ATAC-seq Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for bulk ATAC-seq of isogenic SMARCA4-WT and -KO cell lines
View article: CUT&RUN Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
CUT&RUN Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for CUT&RUN of isogenic SMARCA4-WT and -KO cell lines
View article: RNA-seq (primary tumors) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
RNA-seq (primary tumors) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for bulk RNA-seq of primary tumors isolated from KP, KPS-HET and KPS animals
View article: Bulk ATAC-seq Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Bulk ATAC-seq Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for bulk ATAC-seq of isogenic SMARCA4-WT and -KO cell lines
View article: Supplementary Table S1 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Supplementary Table S1 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Mutations and copy number alterations in PDX models used in this study
View article: Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung adenocarcinoma. However, the functional consequences of SMA…
View article: RNA-seq (primary tumors) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
RNA-seq (primary tumors) Supplementary Data from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Processed data for bulk RNA-seq of primary tumors isolated from KP, KPS-HET and KPS animals
View article: Supplementary Table S1 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Supplementary Table S1 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Mutations and copy number alterations in PDX models used in this study
View article: Supplementary Figures S1-S7 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
Supplementary Figures S1-S7 from <i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung Open
Supplementary Figures related to Figures 1-6
View article: SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung
SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung Open
\n
\n
\n SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung adenocarcinoma. However, the functional consequences of SMARCA4 m…
View article: Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform
Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform Open
Lung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma (LUAD), the most common histological subtype, accounts for 40% of all cases. While existing genetically engineered mouse models (GEMMs) recapitulate th…
View article: Deciphering the immunopeptidome in vivo reveals new tumour antigens
Deciphering the immunopeptidome in vivo reveals new tumour antigens Open
View article: Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform
Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform Open
Lung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma (LUAD), the most common histological subtype, accounts for 40% of all cases. While autochthonous, genetically engineered mouse models (GEMMs) recapitul…
View article: A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells Open
View article: Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform
Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform Open
Lung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma (LUAD), the most common histological subtype, accounts for 40% of all cases. While genetically engineered mouse models (GEMMs) recapitulate the histolo…
View article: Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer Open