Explanipedia

A Prospective, Multicenter Clinical Investigation on the Safety and Performance of a New Active Transcutaneous Bone-Anchored Implant System Open

Tjerk W. Aukema, Sander W. J. Ubbink, David A Lindholm, Peter Monksfield, Thomas Lenarz , et al. · 2025

Objective: To evaluate safety and performance of a new active transcutaneous system, 3 and 6 months postoperatively. Study design: An open, prospective, multicenter clinical investigation with 24-month follow-up. Setting: Six European tert…

Functional analysis of fibroblasts and macrophages in head and neck paragangliomas Open

Paramita Baruah, Jennifer L. Marshall, Meriam Nefla, Valentina Pucino, H. Adams , et al. · 2024

Background and aim Head and neck paragangliomas (HNPGN) are tumours that carry significant morbidity The role of the stroma in the pathogenesis of HNPGN is not completely understood. This study explores the profile of fibroblasts and macro…

Long-Term Patient Satisfaction and Surgical Outcomes With Sophono Implants: A Single-Institution Experience Open

Hesham S. AlMofada, Marion Atkin, Peter Monksfield, Rupan Banga · 2024

Objectives Percutaneous and transcutaneous bone conduction hearing implants are used in various otological conditions. This study aimed to evaluate patient satisfaction with Sophono implants and their long-term surgical outcomes. Methods T…

Outcomes following cochlear implantation with eluting electrodes: A systematic review Open

Alex Fleet, Yasmin Nikookam, Anshul Radotra, Shravan Gowrishankar, Christopher Metcalfe , et al. · 2024

Objectives To establish audiological and other outcomes following cochlear implantation in humans and animals with eluting electrodes. Methods Systematic review and narrative synthesis. Databases searched (April 2023): MEDLINE, EMBASE, CEN…

Single-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets Open

Paramita Baruah, Christopher B. Mahony, Jennifer L. Marshall, Charlotte G. Smith, Peter Monksfield , et al. · 2024

Outcomes of cochlear implantation in Usher syndrome: a systematic review Open

Hannah Louisa Cornwall, Chon Meng Lam, Daoud Chaudhry, Jameel Muzaffar, Peter Monksfield , et al. · 2023

Purpose This study is a systematic review of the literature which seeks to evaluate auditory and quality of life (QOL) outcomes of cochlear implantation in patients with Usher syndrome. Methods Systematic review of studies indexed in Medli…

Outcomes of Cochlear implantation in early‐deafened patients with Waardenburg syndrome: A systematic review and narrative synthesis Open

A Lovett, Michael Eastwood, Chris Metcalfe, Jameel Muzaffar, Peter Monksfield , et al. · 2023

Objective This systematic review aims to establish the expected hearing and speech outcomes following cochlear implantation (CI) in patients with profound congenital deafness secondary to Waardenburg syndrome (WS). Methods A systematic rev…

Radiation treatment of benign tumors in NF2-related-schwannomatosis: A national study of 266 irradiated patients showing a significant increase in malignancy/malignant progression Open

D. Gareth Evans, Dorothy Halliday, Rupert Obholzer, Shazia Afridi, Claire Forde , et al. · 2023

Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from treatment centers suggest safety despite apparent radiation-associated malignancy being reported. We determined…

Long-term osseointegration of laser-ablated hearing implants in sheep cranial bone Open

Martin L. Johansson, Furqan A. Shah, Måns Eeg‐Olofsson, Peter Monksfield, Peter Thomsen , et al. · 2022

Osseointegration, the ability for an implant to be anchored in bone tissue with direct bone-implant contact and allowing for continuous adaptive remodelling, is clinically used in different reconstructive fields, such as dentistry, orthope…

Consensus Statement on Bone Conduction Devices and Active Middle Ear Implants in Conductive and Mixed Hearing Loss Open

H. Maier, Thomas Lenarz, Martijn J.H. Agterberg, Andreas Anagiotos, Susan Arndt , et al. · 2022

Nowadays, several options are available to treat patients with conductive or mixed hearing loss. Whenever surgical intervention is not possible or contra-indicated, and amplification by a conventional hearing device (e.g., behind-the-ear d…

Anatomical and audiological considerations in branchiootorenal syndrome: A systematic review Open

Kirsty Biggs, Gemma Crundwell, Christopher Metcalfe, Jameel Muzaffar, Peter Monksfield , et al. · 2022

Objective Establish anatomical considerations, audiological outcomes, and optimal management in patients with branchiootic/branchiootorenal syndrome (BO/BOR). Methods Databases reviewed: Medline, Pubmed, Embase, Web of Science, Cochrane Co…

Congenital Mastoid Cholesteatoma Open

E. R. V. Richards, Jameel Muzaffar, Wai Sum Cho, Peter Monksfield, Richard Irving · 2022

BACKGROUND: Congenital cholesteatomas account for just up to 5% of all cholesteatomas and most commonly arise in the petrous apex and middle ear. Congenital cholesteatomas arising in the mastoid are rare and typically present late. METHODS…

Cochlear implantation under local anesthetic: A systematic review and<span>meta‐analysis</span> Open

Ben Walters, Peter Gaskell, Jameel Muzaffar, Haissan Iftikhar, Peter Monksfield , et al. · 2022

Objectives As the population ages and implantation criteria are relaxed, more patients with complex comorbidities are becoming eligible for cochlear implantation (CI). These patients have higher risks associated with general anesthesia. Th…

1309 Cochlear Implantation in Patients with Usher Syndrome: A Systematic Review of The Literature Open

Hannah Louisa Cornwall, Christa Lam‐Cassettari, Daoud Chaudhry, Jameel Muzaffar, Peter Monksfield , et al. · 2021

Introduction Usher syndrome is a common cause of deaf-blindness characterised by progressive visual loss with congenital (types 1 and 2) or adult-onset (type 3) sensorineural hearing loss. Cochlear implantation is one of few effective opti…

1136 Cochlear Implant Outcomes in Patients with Otosclerosis: A Systematic Review Open

Christa Lam‐Cassettari, Hannah Louisa Cornwall, Abdullah Chaudhry, Jameel Muzaffar, Manohar Bance , et al. · 2021

Introduction In otosclerosis, spongiotic bone replaces normal bone in the ossicular chain. Focal deposits may also be found within the cochlea leading to sensorineural hearing loss refractory to conventional treatment. Cochlear implantatio…

231 Outcomes of Cochlear Implantation in Patients with Waardenburg Syndrome: A Systematic Review and Narrative Synthesis Open

A Lovett, Michael Eastwood, Chris Metcalfe, Jameel Muzaffar, Peter Monksfield , et al. · 2021

Aim This systematic review aims to establish outcomes of cochlear implantation (CI) in patients with a diagnosis of Waardenburg syndrome (WS). Method A systematic review and narrative synthesis were undertaken. Databases searched: Medline,…

Hearing loss in inner ear and systemic autoimmune disease: A systematic review of post‐cochlear implantation outcomes Open

Jonathan Lee, Kirsty Biggs, Jameel Muzaffar, Manohar Bance, Peter Monksfield · 2021

Objectives To assess outcomes following cochlear implantation (CI) in patients with hearing loss secondary to primary or secondary autoimmune inner ear disease (AIED). Methods A systematic review and narrative synthesis was completed accor…

488 Anatomical and Audiological Considerations in Branchio-otic/Branchio-oto-renal Syndrome: A Systematic Review and Narrative Synthesis Open

Kirsty Biggs, Gemma Crundwell, Chris Metcalfe, Jameel Muzaffar, Peter Monksfield , et al. · 2021

Introduction Branchio-otic/ Branchio-oto-renal syndrome (BO/BOR) is a rare autosomal dominant condition characterised by hearing loss, branchiogenic and renal anomalies. Anatomical variants, audiological outcomes and optimal management are…

805 Eluting Electrodes for Hearing Preservation – the Future of Cochlear Implantation? Open

Yasmin Nikookam, Anshul Radotra, Chris Metcalfe, Jameel Muzaffar, Peter Monksfield , et al. · 2021

Introduction Cochlear implants (CIs) utilising eluting electrodes are a relatively new phenomenon. CI surgery can lead to a variety of complications, namely electrode insertion trauma. This affects CI function leading to a loss of residual…

Outcomes of Cochlear Implantation in Patients with Temporal Bone Trauma: A Systematic Review and Narrative Synthesis Open

Michael Eastwood, Kirsty Biggs, Chris Metcalfe, Jameel Muzaffar, Peter Monksfield , et al. · 2021

Establish outcomes following cochlear implantation (CI) in patients following temporal bone trauma. Systematic review and narrative synthesis. Medline, Pubmed, Embase, Web of Science, Cochrane Collection, and ClinicalTrials.gov. No limits …

Psychosocial outcome measures for conductive and mixed hearing loss treatment: An overview of the relevant literature Open

Amberley Ostevik, Penny Hill-Feltham, Martin L. Johansson, Brian J. McKinnon, Peter Monksfield , et al. · 2021

Only 66 (22%) of the 300 articles with outcomes contained a PRO. Some of the mostly frequently employed PROs (e.g., APHAB) were judged to include only social items and no psychological items. Lack of PRO standardization and the use of IHQs…

Cochlear Implantation Outcomes in Patients with Mitochondrial Hearing Loss: A Systematic Review and Narrative Synthesis Open

Nawal Zia, Yasmin Nikookam, Jameel Muzaffar, Peter Kullar, Peter Monksfield , et al. · 2021

This study’s aim was to establish outcomes following cochlear implantation (CI) in patients with mitochondrial disorders associated with deafness. Systematic review and narrative synthesis. Databases searched: Medline, EMBASE, Web of Scien…

The influence of radiotherapy on outcomes for auricular osseointegrated implants Open

Adam Arshad, Jacquline Chan, Stefan Edmondson, Maarten A. Vijverberg, Myrthe K. S. Hol , et al. · 2020

Following surgical removal of the pinna for malignancy or craniofacial trauma, reconstruction with an auricular prosthesis provides an acceptable cosmetic option. The development of osseointegrated implants for the mounting of such auricul…

Outcomes of Cochlear Implantation in Patients with Jervell and Lange-Nielsen Syndrome: A Systematic Review and Narrative Synthesis Open

Chris Metcalfe, Jameel Muzaffar, Peter Monksfield, Manohar Bance · 2020

Establish outcomes following cochlear implantation (CI) in patients with Jervell and Lange-Nielsen Syndrome (JLNS). Methods Systematic review and narrative synthesis. Databases searched on Medline, Pubmed, Embase, Web of Science, Cochrane …

Outcomes of Cochlear Implantation in Patients with Pendred syndrome: A Systematic Review and Narrative Synthesis Open

Kirsty Biggs, A Lovett, Chris Metcalfe, Jameel Muzaffar, Peter Monksfield , et al. · 2020

Establish outcomes following cochlear implantation (CI) in patients with Pendred syndrome. Systematic review and narrative synthesis. Databases searched: Medline, Pubmed, Embase, Web of Science, Cochrane Collection and ClinicalTrials.gov. …

Cochlear Implantation Outcomes in Post Synaptic Auditory Neuropathies: A Systematic Review and Narrative Synthesis Open

Daoud Chaudhry, Abdullah Chaudhry, Jameel Muzaffar, Peter Monksfield, Manohar Bance · 2020

To establish outcomes following cochlear implantation (CI) in patients with postsynaptic auditory neuropathy (AN). Systematic review and narrative synthesis. Databases searched: MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Collection …

Outcomes of Cochlear Implantation in Patients with Superficial Siderosis: A Systematic Review and Narrative Synthesis Open

Abdullah Chaudhry, Daoud Chaudhry, Jameel Muzaffar, Gemma Crundwell, Peter Monksfield , et al. · 2020

This study aimed to establish outcomes following cochlear implantation (CI) in patients with superficial siderosis (SS). MEDLINE, Embase, Web of Science, Cochrane, and ClinicalTrials.gov databases were searched for this systematic review. …

Hearing outcome measures for conductive and mixed hearing loss treatment in adults: a scoping review Open

Penny Hill-Feltham, Martin L. Johansson, William Hodgetts, Amberley Ostevik, Brian J. McKinnon , et al. · 2020

A wide range of outcome measures are currently used, highlighting the importance of developing a COS to inform individual practice and reporting in trials/research.

Results of a 2-Year Prospective Multicenter Study Evaluating Long-term Audiological and Clinical Outcomes of a Transcutaneous Implant for Bone Conduction Hearing Open

Ivo J. Kruyt, Peter Monksfield, Piotr H. Skarżyński, Kevin Green, Christina L. Runge , et al. · 2020

Objective(s): To evaluate 2-year audiological and clinical outcomes of a transcutaneous implant for bone conduction hearing of a previously published 6-month evaluation. Design: Fifty-four unilaterally implanted adult patients with conduct…

Hearing outcome measures for conductive and mixed hearing loss treatment in adults: a scoping review Open

Penny Hill-Feltham, Martin L. Johansson, William Hodgetts, Amberley Ostevik, Brian J. McKinnon , et al. · 2020

Rehabilitation options for conductive and mixed hearing loss are continually expanding, but without standard outcome measures comparison between different treatments is difficult. To meaningfully inform clinicians and patients core outcome…

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