Peter Mullany
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View article: Removal of mobile genetic elements from the genome of Clostridioides difficile and the implications for the organism’s biology
Removal of mobile genetic elements from the genome of Clostridioides difficile and the implications for the organism’s biology Open
Clostridioides difficile is an emerging pathogen of One Health significance. Its highly variable genome contains mobile genetic elements (MGEs) such as transposons and prophages that influence its biology. Systematic deletion of each genet…
View article: Palidis: fast discovery of novel insertion sequences
Palidis: fast discovery of novel insertion sequences Open
The diversity of microbial insertion sequences, crucial mobile genetic elements in generating diversity in microbial genomes, needs to be better represented in current microbial databases. Identification of these sequences in microbiome co…
View article: Editorial: Microbial interactions of Clostridioides difficile
Editorial: Microbial interactions of Clostridioides difficile Open
© 2023 Goh, Mullany and Riley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/
View article: Palidis: fast discovery of novel insertion sequences
Palidis: fast discovery of novel insertion sequences Open
The diversity of microbial insertion sequences, crucial mobile genetic elements in generating diversity in microbial genomes, needs to be better represented in current microbial databases. Identification of these sequences in microbiome co…
View article: Prevalence of antibiotic resistance genes in the oral cavity and mobile genetic elements that disseminate antimicrobial resistance: A systematic review
Prevalence of antibiotic resistance genes in the oral cavity and mobile genetic elements that disseminate antimicrobial resistance: A systematic review Open
The objective of this review was to assess the prevalence of antibiotic resistance genes in the oral cavity and identify mobile genetic elements (MGEs) important in disseminating them. Additionally, to assess if age, geographic location, o…
View article: Bacterial Integrative Mobile Genetic Elements
Bacterial Integrative Mobile Genetic Elements Open
As our understanding of mobile genetic elements continues to grow we are gaining a deeper appreciation of their importance in shaping the bacterial genome and in the properties they confer to their bacterial hosts. These include, but are b…
View article: Integron gene cassettes harboring novel variants of d-alanine-d-alanine ligase confer high-level resistance to d-cycloserine
Integron gene cassettes harboring novel variants of d-alanine-d-alanine ligase confer high-level resistance to d-cycloserine Open
Antibiotic resistance poses an increasing threat to global health. To tackle this problem, the identification of principal reservoirs of antibiotic resistance genes (ARGs) plus an understanding of drivers for their evolutionary selection a…
View article: The human oral phageome is highly diverse and rich in jumbo phages
The human oral phageome is highly diverse and rich in jumbo phages Open
Until recently, the contribution of bacteriophages to the composition and function of the human microbiome has been largely overlooked. Recent developments in discovering novel bacteriophages from human metagenomes have been mostly focused…
View article: Integron Gene Cassettes Harboring Novel Variants of D-Alanine-D-Alanine Ligase Confer High-level Resistance to D-Cycloserine
Integron Gene Cassettes Harboring Novel Variants of D-Alanine-D-Alanine Ligase Confer High-level Resistance to D-Cycloserine Open
During a PCR-based screen of antibiotic resistance genes (ARGs) associated with integrons in saliva-derived metagenomic DNA of healthy human volunteers, two novel variants of genes encoding a D-alanine-D-alanine ligase ( ddl6 and ddl7 ) lo…
View article: Abundance and diversity of resistomes differ between healthy human oral cavities and gut
Abundance and diversity of resistomes differ between healthy human oral cavities and gut Open
The global threat of antimicrobial resistance has driven the use of high-throughput sequencing techniques to monitor the profile of resistance genes, known as the resistome, in microbial populations. The human oral cavity contains a poorly…
View article: Abundance and diversity of resistomes differ between healthy human oral cavities and gut
Abundance and diversity of resistomes differ between healthy human oral cavities and gut Open
The global threat of the “antimicrobial resistance apocalypse” that has arisen in recent years has driven the use of high-throughput sequencing techniques to monitor the profile of resistance genes, known as the “resistome”, in microbial p…
View article: Promoter activity of ORF-less gene cassettes isolated from the oral metagenome
Promoter activity of ORF-less gene cassettes isolated from the oral metagenome Open
Integrons are genetic elements consisting of a functional platform for recombination and expression of gene cassettes (GCs). GCs usually carry promoter-less open reading frames (ORFs), encoding proteins with various functions including ant…
View article: Plasmids can transfer to Clostridium difficile CD37 and 630Δerm both by a DNase resistant conjugation-like mechanism and a DNase sensitive mechanism
Plasmids can transfer to Clostridium difficile CD37 and 630Δerm both by a DNase resistant conjugation-like mechanism and a DNase sensitive mechanism Open
Broad host range conjugative plasmids that replicate in Escherichia coli have been widely used to mobilise smaller replicons, bearing their cognate origin of transfer (oriT) into a variety of organisms that are less tractable genetically, …
View article: Draft Genome Sequence of Eggerthia catenaformis Strain MAR1 Isolated from Saliva of Healthy Humans
Draft Genome Sequence of Eggerthia catenaformis Strain MAR1 Isolated from Saliva of Healthy Humans Open
Here, we report the draft genome sequence of Eggerthia catenaformis MAR1 isolated during a screen for d -cycloserine-resistant bacteria from the saliva of healthy humans. Analysis of the genome reveals that the strain has the potential to …
View article: Editorial: Phage Therapy: Past, Present and Future
Editorial: Phage Therapy: Past, Present and Future Open
EDITORIAL article Front. Microbiol., 15 June 2017Sec. Antimicrobials, Resistance and Chemotherapy Volume 8 - 2017 | https://doi.org/10.3389/fmicb.2017.00981
View article: PCR-based detection of composite transposons and translocatable units from oral metagenomic DNA
PCR-based detection of composite transposons and translocatable units from oral metagenomic DNA Open
A composite transposon is a mobile genetic element consisting of two insertion sequences (ISs) flanking a segment of cargo DNA often containing antibiotic resistance (AR) genes. Composite transposons can move as a discreet unit. There have…
View article: Detection of Novel Integrons in the Metagenome of Human Saliva
Detection of Novel Integrons in the Metagenome of Human Saliva Open
Integrons are genetic elements capable of capturing and expressing open reading frames (ORFs) embedded within gene cassettes. They are involved in the dissemination of antibiotic resistance genes (ARGs) in clinically important pathogens. A…
View article: Identification of an antibacterial protein by functional screening of a human oral metagenomic library
Identification of an antibacterial protein by functional screening of a human oral metagenomic library Open
This is a corrigendum to the original article published in 2015, updating the author list to include Philip Warburton.
View article: Identification of an antibacterial protein by functional screening of a human oral metagenomic library
Identification of an antibacterial protein by functional screening of a human oral metagenomic library Open
Screening of a bacterial artificial chromosome (BAC) library containing metagenomic DNA from human plaque and saliva allowed the isolation of four clones producing antimicrobial activity. Three of these were pigmented and encoded homologue…
View article: Development of Photodynamic Antimicrobial Chemotherapy (PACT) for Clostridium difficile
Development of Photodynamic Antimicrobial Chemotherapy (PACT) for Clostridium difficile Open
This innovative and simple approach offers the prospect of a new antimicrobial therapy using light to treat C. difficile infection of the colon.