Peter Norberg
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View article: Accurate and Cost‐Efficient Whole Genome Sequencing of Hepatitis B Virus Using Nanopore
Accurate and Cost‐Efficient Whole Genome Sequencing of Hepatitis B Virus Using Nanopore Open
Deep sequencing of the whole hepatitis B virus genome increases the analytical resolution and has the potential to improve molecular epidemiology investigations. The aim of this study was to develop and evaluate the performance of such dee…
View article: OS04.3.A P30-EPS PEPTIDE VACCINE IS SAFE AND IMMUNOGENIC IN NEWLY DIAGNOSED GLIOBLASTOMA: A PHASE 1B TRIAL
OS04.3.A P30-EPS PEPTIDE VACCINE IS SAFE AND IMMUNOGENIC IN NEWLY DIAGNOSED GLIOBLASTOMA: A PHASE 1B TRIAL Open
BACKGROUND The P30-EPS vaccine is a novel multi-epitope peptide immunotherapy targeting class I HLA-A2 epitopes of tumor-associated antigens (EphA2, CMV pp65, survivin) fused to a universal class II helper epitope (P30) to enhance CD4⁺ and…
View article: Accurate and cost-efficient whole genome sequencing of hepatitis B virus using Nanopore
Accurate and cost-efficient whole genome sequencing of hepatitis B virus using Nanopore Open
Deep sequencing of the whole hepatitis B virus genome increases the analytical resolution and has the potential to improve molecular epidemiology investigations. The aim of this work was to develop and evaluate the performance of such deep…
View article: ICTV Virus Taxonomy Profile: Herpesviridae 2021
ICTV Virus Taxonomy Profile: Herpesviridae 2021 Open
Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components. The linear, double-stranded DNA genomes of 125–241 kbp contain 70–170 ge…
View article: Deep Sequencing of Varicella-Zoster Virus in Aqueous Humor From a Patient With Acute Retinal Necrosis Presenting With Acute Glaucoma
Deep Sequencing of Varicella-Zoster Virus in Aqueous Humor From a Patient With Acute Retinal Necrosis Presenting With Acute Glaucoma Open
We report a case of acute retinal necrosis presenting with acute glaucoma preceding inflammatory signs by several days. High-throughput sequencing on aqueous humor revealed a low-level diversity in the viral genome comparable to diversity …
View article: Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection
Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection Open
Herpes simplex viruses (HSV) infect a majority of adults. Recent data have highlighted the genetic diversity of HSV-1 strains and demonstrated apparent genomic relatedness between strains from the same geographic regions. We used HSV-1 cli…
View article: High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis
High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis Open
BACKGROUND: Varicella zoster virus (VZV) may cause encephalitis, both with and without rash. Here we investigate whether viruses recovered from the central nervous system (CNS; encephalitis or meningitis) differ genetically from those reco…
View article: Revisiting Recombination Signal in the Tick-Borne Encephalitis Virus: A Simulation Approach
Revisiting Recombination Signal in the Tick-Borne Encephalitis Virus: A Simulation Approach Open
The hypothesis of wide spread reticulate evolution in Tick-Borne Encephalitis virus (TBEV) has recently gained momentum with several publications describing past recombination events involving various TBEV clades. Despite a large body of w…
View article: Human Tick-Borne Encephalitis and Characterization of Virus from Biting Tick
Human Tick-Borne Encephalitis and Characterization of Virus from Biting Tick Open
We report a case of human tick-borne encephalitis (TBE) in which the TBE virus was isolated from the biting tick. Viral growth and sequence were characterized and compared with those of a reference strain. Virus isolation from ticks from p…
View article: Recombination of Globally Circulating Varicella-Zoster Virus
Recombination of Globally Circulating Varicella-Zoster Virus Open
Varicella-zoster virus (VZV) is a human herpesvirus, which during primary infection typically causes varicella (chicken pox) and establishes lifelong latency in sensory and autonomic ganglia. Later in life, the virus may reactivate to caus…
View article: Published sequences do not support transfer of oseltamivir resistance mutations from avian to human influenza A virus strains
Published sequences do not support transfer of oseltamivir resistance mutations from avian to human influenza A virus strains Open
The results indicate that resistance in influenza viruses infecting humans is due to the selection pressure posed by the global OE administration in humans rather than transfer from avian influenza A virus strains carrying mutations induce…