Piotr Nowak
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View article: A human pan-disease blood atlas of the circulating proteome
A human pan-disease blood atlas of the circulating proteome Open
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a …
View article: The effect of remdesivir and nirmatrelvir/ritonavir on mortality in patients hospitalized with COVID-19 during the Omicron era: an emulated target trial
The effect of remdesivir and nirmatrelvir/ritonavir on mortality in patients hospitalized with COVID-19 during the Omicron era: an emulated target trial Open
Treatment with remdesivir and/or nirmatrelvir/ritonavir was associated with reduced mortality in hospitalized SARS-CoV-2-infected patients during the Omicron era, primarily in unvaccinated individuals without previous infection. Our findin…
Risk factors for further recurrences of Clostridioides difficile infection at the first and second recurrence: a retrospective cohort Open
Background Recurrent Clostridioides difficile infection is most effectively treated with faecal microbiota transplantation. Swedish and European guidelines suggest faecal microbiota transplantation after a first or second recurrence, respe…
Factors mediating and associated with immunological response in women living with <span>HIV</span> in Sweden: A nationwide register‐based study Open
Introduction Women remain underrepresented in studies on immunological response (IR) among virally suppressed people living with HIV. Despite receiving antiretroviral therapy (ART) some individuals do not attain an IR, increasing their ris…
View article: Linking Gut Microbiome to HIV-1 Reservoir Size in People Living with HIV
Linking Gut Microbiome to HIV-1 Reservoir Size in People Living with HIV Open
The gut microbiome is altered during HIV-1 infection contributing to immune dysfunction and inflammation in people living with HIV (PLWH) that persists despite antiretroviral therapy (ART). We explored the associations between the gut micr…
View article: Dysregulated Adaptive Immune Responses to SARS-CoV-2 in Immunocompromised Individuals
Dysregulated Adaptive Immune Responses to SARS-CoV-2 in Immunocompromised Individuals Open
The SARS-CoV-2 virus poses a significant risk to immunocompromised patients, who display weakened immunity and reduced seroconversion following infection and vaccination. In this study, we recruited 19 hospitalized patients with immune dis…
Metformin Treatment and Immune Reconstitution in People With HIV and Type 2 Diabetes: A Matched Retrospective Study Open
Background Despite effective antiretroviral treatment (ART), HIV infection is associated with immune dysfunction and inflammation. Metformin has shown beneficial immunological and anti-inflammatory effects, including in people with HIV (PW…
P-471. Clinical and Laboratory Characteristics of the Stockholm HTLV Cohort Open
Background The prevalence of HTLV infection in Sweden is presumed to be low, however the impact of demographic changes during the last 20 years on HTLV prevalence is unknown. In our study we describe clinical and laboratory characteristics…
Altered Glycolysis–TCA Anaplerosis Axis Impairs Monocyte Migration and Trains Macrophage Polarization in Long-term Treated HIV Infection Open
Cells of the myeloid lineage, particularly monocytes and macrophages, are central to HIV pathogenesis, contributing to viral persistence and immune regulation during suppressive therapy. We hypothesized that metabolic reprogramming and alt…
PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription Open
HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Some of these reservoir cells can at anytime be reactivated and reinitiate infection. The mecha…
View article: Exploring the interplay between antiretroviral therapy and the gut-oral microbiome axis in people living with HIV
Exploring the interplay between antiretroviral therapy and the gut-oral microbiome axis in people living with HIV Open
Background : The gut and oral microbiome is altered in people living with HIV (PLWH). While antiretroviral treatment (ART) is pivotal in restoring immune function in PLWH, several studies have identified an association between specific ant…
Cytomegalovirus infection among people living with <span>HIV</span> in Sweden: Case profiles, treatment strategies and patient outcomes at Karolinska University Hospital 2010–2020 Open
Objectives In countries with access to early antiretroviral treatment (ART), opportunistic infections caused by cytomegalovirus (CMV) in people living with HIV (PLWH) are becoming increasingly rare. As potential complications are severe, i…
View article: Anakinra or tocilizumab in patients admitted to hospital with severe covid-19 at high risk of deterioration (IMMCoVA): A randomized, controlled, open-label trial
Anakinra or tocilizumab in patients admitted to hospital with severe covid-19 at high risk of deterioration (IMMCoVA): A randomized, controlled, open-label trial Open
Background Anakinra and tocilizumab are used for severe Covid-19, but only one previous randomized controlled trial (RCT) has studied both. We performed a multi-center RCT comparing anakinra or tocilizumab versus usual care (UC) for adults…
View article: Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV
Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV Open
Although mRNA SARS-CoV-2 vaccines are generally safe and effective, in certain immunocompromised individuals they can elicit poor immunogenic responses. Among these individuals, people living with HIV (PLWH) have poor immunogenicity to sev…
View article: The cascade of care for patients with chronic hepatitis delta in Southern Stockholm, Sweden for the past 30 years
The cascade of care for patients with chronic hepatitis delta in Southern Stockholm, Sweden for the past 30 years Open
Background and Aims Previous studies have shown suboptimal screening for hepatitis D virus (HDV) among patients with chronic hepatitis B (CHB). This study presents the cascade of care for HDV infection in a major secondary referral centre …
View article: Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states
Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states Open
Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in individuals with various immunodeficiencies. Given the increased antibody evasion properties of emerging SARS-CoV-2 subvariants, it is necessary to assess w…
View article: Anamnestic expansion of Omicron-reactive CD8+ T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states
Anamnestic expansion of Omicron-reactive CD8+ T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states Open
Restricted immune responses to SARS-CoV-2 mRNA vaccination have been observed frequently in individuals suffering from various immunodeficiencies. With increased antibody evasion properties of rising Omicron subvariants, there is a need to…
Role of myeloid cells in system-level immunometabolic dysregulation during prolonged successful HIV-1 treatment Open
Objective: Why people with HIV-1 on ART (PWH ART ) display convoluted metabolism and immune cell functions during prolonged suppressive therapy is not well evaluated. In this study, we aimed to address this question using multiomics method…
Successful Combination Treatment for Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection Open
Journal Article Successful Combination Treatment for Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection Get access Ola Blennow, Ola Blennow Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Swe…
Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV Open
Although mRNA SARS-CoV-2 vaccines are generally safe and effective, in certain immunocompromised individuals they can elicit poor immunogenic responses. Among these individuals, people living with HIV (PLWH) have poor immunogenicity to sev…
Persistence of salivary antibody responses after COVID-19 vaccination is associated with oral microbiome variation in both healthy and people living with HIV Open
Coevolution of microbiome and immunity at mucosal sites is essential for our health. Whether the oral microbiome, the second largest community after the gut, contributes to the immunogenicity of COVID-19 vaccines is not known. We investiga…
View article: Outcome of infection with omicron <scp>SARS‐CoV</scp>‐2 variant in patients with hematological malignancies: An <scp>EPICOVIDEHA</scp> survey report
Outcome of infection with omicron <span>SARS‐CoV</span>‐2 variant in patients with hematological malignancies: An <span>EPICOVIDEHA</span> survey report Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused high mortality in patients with hematological malignancies (HM).1 The newly emerged omicron variants of SARS-CoV-2 harbor multiple novel spike protein mutati…