Peter Oatley
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View article: Spatial organization of Clostridium difficile S-layer biogenesis
Spatial organization of Clostridium difficile S-layer biogenesis Open
Surface layers (S-layers) are protective protein coats which form around all archaea and most bacterial cells. Clostridium difficile is a Gram-positive bacterium with an S-layer covering its peptidoglycan cell wall. The S-layer in C. diffi…
View article: A cortex-specific PBP contributes to cephalosporin resistance in <i>Clostridium difficile</i>
A cortex-specific PBP contributes to cephalosporin resistance in <i>Clostridium difficile</i> Open
Sporulation is a complex cell differentiation programme shared by many members of the Firmicutes, the end result of which is a highly resistant, metabolically inert spore that can survive harsh environmental insults. Clostridium difficile …
View article: Spatial organization of <i>Clostridium difficile</i> S-layer biogenesis
Spatial organization of <i>Clostridium difficile</i> S-layer biogenesis Open
Surface layers (S-layers) are protective protein coats which form around all archaea and most bacterial cells. Clostridium difficile is a Gram-positive bacterium with an S-layer covering its peptidoglycan cell wall. The S-layer in C. diffi…
View article: Dynamic action of the Sec machinery during initiation, protein translocation and termination
Dynamic action of the Sec machinery during initiation, protein translocation and termination Open
Protein translocation across cell membranes is a ubiquitous process required for protein secretion and membrane protein insertion. In bacteria, this is mostly mediated by the conserved SecYEG complex, driven through rounds of ATP hydrolysi…
View article: Dynamic action of the Sec machinery during initiation, protein translocation and termination revealed by single molecule fluorescence
Dynamic action of the Sec machinery during initiation, protein translocation and termination revealed by single molecule fluorescence Open
Protein translocation across cell membranes is a ubiquitous process required for protein secretion and membrane protein insertion. This is mediated, for the majority of proteins, by the highly conserved Sec machinery. The bacterial translo…
View article: Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation
Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation Open
The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF…
View article: Author response: Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation
Author response: Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The essential …