Peter Owens
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View article: Iron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model
Iron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model Open
ACC cells actively internalise IONPs without significant impairment of viability or steroidogenesis at pharmacologically relevant concentrations. However, non-specific uptake by monocytes and endothelial cells reduces delivery efficiency. …
View article: In vitro co-culture of <i>Fasciola hepatica</i> newly excysted juveniles (NEJs) with 3D HepG2 spheroids permits novel investigation of host–parasite interactions
In vitro co-culture of <i>Fasciola hepatica</i> newly excysted juveniles (NEJs) with 3D HepG2 spheroids permits novel investigation of host–parasite interactions Open
Fasciola hepatica, or liver fluke, causes fasciolosis in humans and livestock. Following ingestion of vegetation contaminated with encysted parasites, metacercariae, newly excysted juveniles (NEJ) excyst in the small intestine and cross th…
View article: Hyaluronic acid hydrogels: Establishing a sustained delivery system for extracellular vesicles
Hyaluronic acid hydrogels: Establishing a sustained delivery system for extracellular vesicles Open
Extracellular vesicles (EVs) are versatile transporters of genetic cargo with enormous potential in the therapeutic setting. Scalable production of EVs, and routes to overcome rapid clearance are required. Biocompatible hydrogels may suppo…
View article: Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles
Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles Open
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis, treated primarily through surgery and chemotherapy. Other treatments like radiation or thermal ablation for metastases have limited success, and recurrence is common. Mor…
View article: Synthetic Fourier Domain Optical Coherence Tomography
Synthetic Fourier Domain Optical Coherence Tomography Open
A novel approach for image formation in optical coherence tomography (OCT) and microscopy is presented. The depth resolution of OCT, including recently developed nanosensitive OCT (nsOCT), is limited by the spectral bandwidth of the light …
View article: Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy
Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy Open
Excision biopsy and histology represent the gold standard for morphological investigation of the skin, in particular for cancer diagnostics. Nevertheless, a biopsy may alter the original morphology, usually requires several weeks for resul…
View article: Establishing electroporation thresholds for targeted cell specific cardiac ablation in a 2D culture model
Establishing electroporation thresholds for targeted cell specific cardiac ablation in a 2D culture model Open
Background Irreversible electroporation has emerged as a new modality to overcome issues associated with other energy sources for cardiac ablation. Strong evidence on the optimal, effective, and selective voltage threshold is lacking for b…
View article: Bis-Indole Alkaloids Isolated from the Sponge Spongosorites calcicola Disrupt Cell Membranes of MRSA
Bis-Indole Alkaloids Isolated from the Sponge Spongosorites calcicola Disrupt Cell Membranes of MRSA Open
Antimicrobial resistance (AMR) is a global health challenge with methicillin resistant Staphylococcus aureus (MRSA), a leading cause of nosocomial infection. In the search for novel antibiotics, marine sponges have become model organisms a…
View article: Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep
Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep Open
An injectable functionalized elastin-inspired hydrogel improves cardiac functional response in sheep and preserves cardiomyocytes in the border zone.
View article: Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody
Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody Open
Intramuscular administration of mesenchymal stromal cells (MSCs) represents a therapeutic option for diabetic critical limb ischemia. Autologous or allogeneic approaches may be used but disease-induced cell dysfunction may limit therapeuti…
View article: Quartz-Amethyst Hosted Hydrocarbon-Bearing Fluid Inclusions from the Green Ridge Breccia in the Snoqualmie Granite, North Cascades, WA, USA
Quartz-Amethyst Hosted Hydrocarbon-Bearing Fluid Inclusions from the Green Ridge Breccia in the Snoqualmie Granite, North Cascades, WA, USA Open
The Green Ridge Breccia cuts the composite Miocene Snoqualmie Batholith in King County, WA, USA. The granite was emplaced at ~5 km depth between ~17 and 20 Ma and the crosscutting NW trending breccia contains large angular blocks of the ho…
View article: Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template
Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template Open
In vitro bone regeneration strategies that prime mesenchymal stem cells (MSCs) with chondrogenic factors, to mimic aspects of the endochondral ossification process, have been shown to promote mineralization and vascularization by MSCs both…
View article: In vivo correlation mapping microscopy
In vivo correlation mapping microscopy Open
To facilitate regular assessment of the microcirculation in vivo, noninvasive imaging techniques such as nailfold capillaroscopy are required in clinics. Recently, a correlation mapping technique has been applied to optical coherence tomog…
View article: Modulation of Extracellular Matrix Activity, Neurotropic Factors and Sensory Innervation Associated Pain in Intervertebral Disc Degeneration using a Hyaluronic Acid Hydrogel
Modulation of Extracellular Matrix Activity, Neurotropic Factors and Sensory Innervation Associated Pain in Intervertebral Disc Degeneration using a Hyaluronic Acid Hydrogel Open
Introduction Painful intervertebral disc (IVD) degeneration is mediated by inflammation, increase catabolic processes and neurotrophin production that sensitize innervation in the disc and leading to back pain. High molecular weight hyalur…
View article: Sensing of p53 and EGFR Biomarkers Using High Efficiency SERS Substrates
Sensing of p53 and EGFR Biomarkers Using High Efficiency SERS Substrates Open
In this paper we describe a method for the determination of protein concentration using Surface Enhanced Raman Resonance Scattering (SERRS) immunoassays. We use two different Raman active linkers, 4-aminothiophenol and 6-mercaptopurine, to…
View article: Additional file 4: Figure S4. of ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells
Additional file 4: Figure S4. of ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells Open
Human BMSC chemotactic migration is unaffected by ROCK inhibition but does display the characteristic morphology. a Serum-starved human BMSCs polarise in response to MCP-1; 10 μM Y27632 treatment results in stellate morphology in BMSCs, in…