Peter Paul De Deyn
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View article: Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease
Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease Open
Extensive evidence suggests overlapping pathological mechanisms in the brain of individuals with Parkinson´s disease dementia, Down syndrome dementia, and Alzheimer´s disease. For these neurodegenerative dementias, we observed that the chr…
View article: Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease
Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease Open
Alzheimer's disease (AD) is an age-related neurodegenerative disorder and the most common cause of dementia. While the amyloid cascade hypothesis has long dominated AD research, emerging evidence suggests that neuroinflammation may play a …
View article: Disease‐specific neuropathological alterations of the <i>locus coeruleus</i> in Alzheimer's disease, Down syndrome, and Parkinson's disease
Disease‐specific neuropathological alterations of the <i>locus coeruleus</i> in Alzheimer's disease, Down syndrome, and Parkinson's disease Open
INTRODUCTION The locus coeruleus (LC), the brain's primary source of noradrenaline (NA), undergoes early neurodegeneration in Parkinson's disease (PD), Alzheimer's diseases (AD), and Down syndrome (DS); however, differences have not been e…
View article: Copy Number Variation and Haplotype Analysis of <scp>17q21.31</scp> Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells
Copy Number Variation and Haplotype Analysis of <span>17q21.31</span> Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells Open
Background The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP). Objective To inve…
View article: GL-ICNN: An End-To-End Interpretable Convolutional Neural Network for the Diagnosis and Prediction of Alzheimer's Disease
GL-ICNN: An End-To-End Interpretable Convolutional Neural Network for the Diagnosis and Prediction of Alzheimer's Disease Open
Deep learning methods based on Convolutional Neural Networks (CNNs) have shown great potential to improve early and accurate diagnosis of Alzheimer's disease (AD) dementia based on imaging data. However, these methods have yet to be widely…
View article: Rare Abca7 Mutations in Alzheimer's Disease and Cerebral Amyloid Angiopathy Pathology
Rare Abca7 Mutations in Alzheimer's Disease and Cerebral Amyloid Angiopathy Pathology Open
View article: Correlation analyses between MIBG myocardial scintigraphy and monoamine levels in dementia with Lewy bodies show potential link with the serotonergic system
Correlation analyses between MIBG myocardial scintigraphy and monoamine levels in dementia with Lewy bodies show potential link with the serotonergic system Open
View article: Correlations between monoaminergic biomarkers, classical biomarkers and the BPSD‐DSII behavioral scale in Down individuals with and without Alzheimer's dementia
Correlations between monoaminergic biomarkers, classical biomarkers and the BPSD‐DSII behavioral scale in Down individuals with and without Alzheimer's dementia Open
Background Down syndrome (DS, trisomy 21) is the most frequent genetic cause of intellectual disability (ID), prevalent in approximately 1 in 900 live births (Loane et al., 2013). People with DS are at high risk to develop Alzheimer’s dise…
View article: Coronary artery calcium and Alzheimer’s Disease biomarkers in cognitively unimpaired adults
Coronary artery calcium and Alzheimer’s Disease biomarkers in cognitively unimpaired adults Open
Background Atherosclerosis, the hardening of arterial walls resulting in atherosclerotic plaques, is linked to cognitive dysfunction and an increased risk of cognitive decline. Findings on the impact of high coronary artery calcium (CAC), …
View article: Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy Open
View article: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy Open
View article: Alterations in Gray Matter Structural Networks in Amnestic Mild Cognitive Impairment: A Source-Based Morphometry Study
Alterations in Gray Matter Structural Networks in Amnestic Mild Cognitive Impairment: A Source-Based Morphometry Study Open
Background: Amnestic mild cognitive impairment (aMCI), considered as the prodromal stage of Alzheimer’s disease, is characterized by isolated memory impairment and cerebral gray matter volume (GMV) alterations. Previous structural MRI stud…
View article: Antigen-specific age-related memory CD8 T cells induce and track Alzheimer’s-like neurodegeneration
Antigen-specific age-related memory CD8 T cells induce and track Alzheimer’s-like neurodegeneration Open
Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer’s disease (AD), yet are insufficient to confer complete AD-like neurodegeneration experimentally. Factors acting upstream of Aβ/pTau in AD remain unknown, but the…
View article: Financial capability of people living with Parkinson’s disease – A case-control study
Financial capability of people living with Parkinson’s disease – A case-control study Open
Parkinson's disease (PD) is a neurodegenerative disorder affecting 1% of people older than 60 years. One of the abilities that seems vulnerable to the cognitive impairments associated with PD is financial capability. This explorative study…
View article: Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study
Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study Open
View article: Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study
Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study Open
Performance in psychomotor function, visual attention, visual learning, and working memory measured by the Cogstate Brief Battery did not differ between individuals with different changes in metabolic syndrome. The length of metabolic synd…
View article: Accumulation of Ambient Black Carbon Particles Within Key Memory-Related Brain Regions
Accumulation of Ambient Black Carbon Particles Within Key Memory-Related Brain Regions Open
Importance Ambient air pollution is a worldwide problem, not only related to respiratory and cardiovascular diseases but also to neurodegenerative disorders. Different pathways on how air pollutants could affect the brain are already known…
View article: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we combine RNA sequencing with…
View article: Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Methods Data availability References Article and author information Abstract Exposure to an acute stressor triggers a complex cas…
View article: Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and<i>MAPT</i>Sub-haplotypes
Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and<i>MAPT</i>Sub-haplotypes Open
Importance The chromosome 17q21.31 region, containing a 900 Kb inversion that defines H1 and H2 haplotypes, represents the strongest genetic risk locus in progressive supranuclear palsy (PSP). In addition to H1 and H2, various structural f…
View article: Clinical variables contributing to the identification of biologically defined subgroups within cognitively unimpaired and mild cognitive impairment individuals
Clinical variables contributing to the identification of biologically defined subgroups within cognitively unimpaired and mild cognitive impairment individuals Open
Background A lack of consensus exists in linking demographic, behavioral, and cognitive characteristics to biological stages of dementia, defined by the ATN (amyloid, tau, neurodegeneration) classification incorporating amyloid, tau, and n…
View article: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Author Response: Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Reviewer #2 (Public Review): Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression
Reviewer #2 (Public Review): Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Open
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here we combine RNA-sequencing with …
View article: Antigen-specific age-related memory CD8 T cells induce and track Alzheimer’s-like neurodegeneration
Antigen-specific age-related memory CD8 T cells induce and track Alzheimer’s-like neurodegeneration Open
Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer’s disease (AD), yet are insufficient to confer complete AD-like neurodegeneration experimentally. Factors acting upstream of Aβ/pTau in AD remain unknown, but the…
View article: Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function
Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function Open
Background: Dementia is a multifactorial disease, with Alzheimer’s disease (AD) and vascular pathology often co-occurring in many individuals with dementia. Yet, the interplay between AD and vascular pathology in cognitive decline is large…
View article: Epigenetics and Down syndrome
Epigenetics and Down syndrome Open
View article: Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy
Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy Open
Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP…
View article: Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice
Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice Open
Due to global population growth, age-related disorders like cardiovascular disease and dementia are anticipated to increase. Recent data suggests a connection between cardiovascular disease and neurodegeneration, especially focusing on art…
View article: Small vessel disease burden and functional brain connectivity in mild cognitive impairment
Small vessel disease burden and functional brain connectivity in mild cognitive impairment Open