Peter R. Strege
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View article: Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma 4365
Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma 4365 Open
Description In the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword—they are a major cellular component suppressing the immune response while serving as a promising therapeutic target. Our study sheds light…
View article: Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma
Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma Open
In the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword—they are a major cellular component modulating the immune response while presenting a potential therapeutic target. Our study highlights the voltage-g…
View article: WCN24-1683 THE HOMOLOG OF ANOCTAMIN 4 LIMITS CALCIUM OXALATE CRYSTALLIZATION BY PREVENTING GRAM-NEGATIVE BACTERIA INFECTION IN DROSOPHILA RENAL TUBULES
WCN24-1683 THE HOMOLOG OF ANOCTAMIN 4 LIMITS CALCIUM OXALATE CRYSTALLIZATION BY PREVENTING GRAM-NEGATIVE BACTERIA INFECTION IN DROSOPHILA RENAL TUBULES Open
An anoctamin 4 (ANO4) mutation was identified in dogs with calcium oxalate (CaOx) stones via GWAS, and the content of ANO4 is decreased in urinary extracellular vesicles of human CaOx stone formers. ANO proteins are Ca2+-activated Clchanne…
View article: Stretch response of the mechano-gated channel TMEM63A in membrane patches and single cells
Stretch response of the mechano-gated channel TMEM63A in membrane patches and single cells Open
TMEM63A has biophysical features distinctive for mechano-gated cation channels, but some properties are less clear, including no functional information in whole cells. We report that pressure-dependent yet voltage-independent TMEM63A curre…
View article: Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel Open
Voltage-gated ion channels (VGICs) orchestrate electrical activities that drive mechanical functions in contractile tissues such as the heart and gut. In turn, contractions change membrane tension and impact ion channels. VGICs are mechano…
View article: Author response: Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
Author response: Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel Open
View article: Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel Open
Voltage-gated ion channels orchestrate electrical activities that drive mechanical functions in contractile tissues such as the heart and gut. In turn, contractions change membrane tension and impact ion channels. Voltage-gated ion channel…
View article: Capsaicin as an amphipathic modulator of Na<sub>V</sub>1.5 mechanosensitivity
Capsaicin as an amphipathic modulator of Na<sub>V</sub>1.5 mechanosensitivity Open
SCN5A-encoded NaV1.5 is a voltage-gated Na+ channel that drives the electrical excitability of cardiac myocytes and contributes to slow waves of the human gastrointestinal smooth muscle cells. NaV1.5…
View article: Capsaicin alters human Na<sub>V</sub>1.5 mechanosensitivity
Capsaicin alters human Na<sub>V</sub>1.5 mechanosensitivity Open
SCN5A -encoded Na V 1.5 is a voltage-gated Na + channel expressed in cardiac myocytes and human gastrointestinal (GI) smooth muscle cells (SMCs). Na V 1.5 contributes to electrical excitability in the heart and slow waves in the gut. Na V …
View article: Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease Open
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study …
View article: Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels
Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels Open
Mechanosensation, the ability to properly sense mechanical stimuli and transduce them into physiologic responses, is an essential determinant of gastrointestinal (GI) function. Abnormalities in this process result in highly prevalent GI fu…
View article: Expression of the regulated isoform of the electrogenic Na<sup>+</sup>/HCO<sub>3</sub><sup>−</sup> cotransporter, NBCe1, is enriched in pacemaker interstitial cells of Cajal
Expression of the regulated isoform of the electrogenic Na<sup>+</sup>/HCO<sub>3</sub><sup>−</sup> cotransporter, NBCe1, is enriched in pacemaker interstitial cells of Cajal Open
In this study, we show that the electrogenic Na+/HCO 3 − cotransporter, NBCe1/Slc4a4, is expressed in subtypes of interstitial cells of Cajal (ICCs) responsible for electrical slow wave generation throughout the mouse gastrointestinal trac…
View article: microRNA overexpression in slow transit constipation leads to reduced Na <sub>V</sub> 1.5 current and altered smooth muscle contractility
microRNA overexpression in slow transit constipation leads to reduced Na <sub>V</sub> 1.5 current and altered smooth muscle contractility Open
Objective This study was designed to evaluate the roles of microRNAs (miRNAs) in slow transit constipation (STC). Design All human tissue samples were from the muscularis externa of the colon. Expression of 372 miRNAs was examined in a dis…
View article: Direct repression of anoctamin 1 ( <i>ANO1</i> ) gene transcription by Gli proteins
Direct repression of anoctamin 1 ( <i>ANO1</i> ) gene transcription by Gli proteins Open
The Ca 2+ ‐activated Cl − channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development. The human ANO1 promoter contains binding s…
View article: <i>SCN5A</i> mutation G615E results in Na<sub>V</sub>1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity
<i>SCN5A</i> mutation G615E results in Na<sub>V</sub>1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity Open
SCN5A is expressed in cardiomyocytes and gastrointestinal (GI) smooth muscle cells (SMCs) as the voltage-gated mechanosensitive sodium channel NaV1.5. The influx of Na+ through NaV1.5 produces a fast…
View article: Ezh2-dependent epigenetic reprogramming controls a developmental switch between modes of gastric neuromuscular regulation
Ezh2-dependent epigenetic reprogramming controls a developmental switch between modes of gastric neuromuscular regulation Open
SUMMARY Physiological interconversion between specialized cell types has only been described in a few mammalian tissues and the mechanisms remain obscure. Using genetic lineage tracing during postnatal development and in-vitro models we de…
View article: Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells
Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells Open
Enterochromaffin (EC) cells in the gastrointestinal (GI) epithelium constitute the largest subpopulation of enteroendocrine cells. As specialized sensory cells, EC cells sense luminal stimuli and convert them into serotonin (5-hyroxytrypta…
View article: A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release Open
Significance Mechanical forces are important for normal gastrointestinal tract function. The enterochromaffin cells in the gastrointestinal epithelium have been proposed, but not previously shown, to be specialized sensors that convert for…
View article: Irritable bowel syndrome patients have<i>SCN5A</i>channelopathies that lead to decreased Na<sub>V</sub>1.5 current and mechanosensitivity
Irritable bowel syndrome patients have<i>SCN5A</i>channelopathies that lead to decreased Na<sub>V</sub>1.5 current and mechanosensitivity Open
The SCN5A-encoded voltage-gated mechanosensitive Na + channel Na V 1.5 is expressed in human gastrointestinal smooth muscle cells and interstitial cells of Cajal. Na V 1.5 contributes to smooth muscle electrical slow waves and mechanical s…
View article: Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release
Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release Open
View article: EAVK segment “c” sequence confers Ca<sup>2+</sup>-dependent changes to the kinetics of full-length human Ano1
EAVK segment “c” sequence confers Ca<sup>2+</sup>-dependent changes to the kinetics of full-length human Ano1 Open
Anoctamin1 (Ano1 and TMEM16A) is a calcium-activated chloride channel specifically expressed in the interstitial cells of Cajal (ICC) of the gastrointestinal tract muscularis propria. Ano1 is necessary for normal electrical slow waves and …
View article: Mechanosensitivity of the Bacterial Voltage-Gated Sodium Channel NaChBac
Mechanosensitivity of the Bacterial Voltage-Gated Sodium Channel NaChBac Open
View article: Expression and function of the <i>Scn5a</i>‐encoded voltage‐gated sodium channel Na<sub>V</sub>1.5 in the rat jejunum
Expression and function of the <i>Scn5a</i>‐encoded voltage‐gated sodium channel Na<sub>V</sub>1.5 in the rat jejunum Open
Background The SCN5A ‐encoded voltage‐gated sodium channel Na V 1.5 is expressed in human jejunum and colon. Mutations in Na V 1.5 are associated with gastrointestinal motility disorders. The rat gastrointestinal tract expresses voltage‐ga…
View article: Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells
Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells Open
Human jejunum smooth muscle cells (SMCs) and interstitial cells of Cajal (ICCs) express the SCN5A-encoded voltage-gated, mechanosensitive sodium channel Na V 1.5. Na V 1.5 contributes to small bowel excitability, and Na V 1.5 inhibitor ran…