Peter Rappl
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View article: Concentrations of uremic bacterial metabolites in patients with post-COVID-19 syndrome
Concentrations of uremic bacterial metabolites in patients with post-COVID-19 syndrome Open
Post-COVID-19 syndrome (PCS) is characterized by persistent symptoms and reduced mental and physical performance following the acute phase of COVID-19. The underlying mechanisms remain unclear but may involve gut microbiota dysbiosis and i…
View article: Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation
Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation Open
Despite the importance of rapid adaptive responses in the course of inflammation and the notion that post-transcriptional regulation plays an important role herein, relevant translational alterations, especially during the resolution phase…
View article: Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression
Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression Open
Macrophages are a highly versatile and heterogenic group of immune cells, known for their involvement in inflammatory reactions. However, our knowledge about distinct subpopulations of macrophages and their specific contribution to the res…
View article: Apoptotic Cells induce Proliferation of Peritoneal Macrophages
Apoptotic Cells induce Proliferation of Peritoneal Macrophages Open
The interaction of macrophages with apoptotic cells is required for efficient resolution of inflammation. While apoptotic cell removal prevents inflammation due to secondary necrosis, it also alters the macrophage phenotype to hinder furth…
View article: Role of Tristetraprolin in the Resolution of Inflammation
Role of Tristetraprolin in the Resolution of Inflammation Open
Inflammation is a crucial part of immune responses towards invading pathogens or tissue damage. While inflammatory reactions are aimed at removing the triggering stimulus, it is important that these processes are terminated in a coordinate…
View article: Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation
Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation Open
While aberrant cells are routinely recognized and removed by immune cells, tumors eventually escape innate immune responses. Infiltrating immune cells are even corrupted by the tumor to acquire a tumor-supporting phenotype. In line, tumor-…