Peter Redder
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View article: Ribonuclease toxin RelE1 inhibits growth of <i>Mycobacterium tuberculosis</i> through specific cleavage of the ribosomal anti-Shine–Dalgarno region
Ribonuclease toxin RelE1 inhibits growth of <i>Mycobacterium tuberculosis</i> through specific cleavage of the ribosomal anti-Shine–Dalgarno region Open
Toxin–antitoxin (TA) systems are central to bacterial immunity, genome maintenance, and pathogenicity. Toxins of TA systems use diverse strategies to control bacterial growth and represent attractive therapeutic targets to fight pathogens.…
View article: <i>rnaends</i> : an R package to study exact RNA ends at nucleotide resolution
<i>rnaends</i> : an R package to study exact RNA ends at nucleotide resolution Open
A bstract 5’ and 3’ RNA-end sequencing protocols have unlocked new opportunities to study aspects of RNA metabolism such as synthesis, maturation and degradation, by enabling the quantification of exact ends of RNA molecules in vivo . From…
View article: Nucleotidyltransferase toxin MenT extends aminoacyl acceptor ends of serine tRNAs to control Mycobacterium tuberculosis growth
Nucleotidyltransferase toxin MenT extends aminoacyl acceptor ends of serine tRNAs to control Mycobacterium tuberculosis growth Open
Toxins of toxin-antitoxin systems use diverse mechanisms to inhibit bacterial growth. In this study, we characterize the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis , the bacterium responsible for tuberculosis in humans…
View article: Critical factors for precise and efficient RNA cleavage by RNase Y in Staphylococcus aureus
Critical factors for precise and efficient RNA cleavage by RNase Y in Staphylococcus aureus Open
Cellular processes require precise and specific gene regulation, in which continuous mRNA degradation is a major element. The mRNA degradation mechanisms should be able to degrade a wide range of different RNA substrates with high efficien…
View article: Nucleotidyltransferase toxin MenT targets and extends the aminoacyl acceptor ends of serine tRNAs<i>in vivo</i>to control<i>Mycobacterium tuberculosis</i>growth
Nucleotidyltransferase toxin MenT targets and extends the aminoacyl acceptor ends of serine tRNAs<i>in vivo</i>to control<i>Mycobacterium tuberculosis</i>growth Open
Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth and represent attractive therapeutic targets to fight pathogens. In this study, we characterized the translation inhibitor toxin MenT3 of Mycobacterium tu…
View article: Critical factors for precise and efficient RNA cleavage by RNase Y in<i>Staphylococcus aureus</i>
Critical factors for precise and efficient RNA cleavage by RNase Y in<i>Staphylococcus aureus</i> Open
Cellular processes require precise and specific gene regulation, in which continuous mRNA degradation is a major element. The mRNA degradation mechanisms should be able to degrade a wide range of different RNA substrates with high efficien…
View article: RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication
RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication Open
Plasmids need to ensure their transmission to both daughter-cells when their host divides, but should at the same time avoid overtaxing their hosts by directing excessive host-resources toward production of plasmid factors. Naturally occur…
View article: Occurrence and distribution of fecal indicators and pathogenic bacteria in seawater and<i>Perna perna</i>mussel in the Gulf of Annaba (Southern Mediterranean)
Occurrence and distribution of fecal indicators and pathogenic bacteria in seawater and<i>Perna perna</i>mussel in the Gulf of Annaba (Southern Mediterranean) Open
The brown mussel Perna perna is a marine bivalve that is widely distributed and consumed along the east coast of Algeria. Due to its filter-feeding capacity, this mollusk can accumulate large quantities of pathogenic microorganisms from th…
View article: Insights into the global effect on Staphylococcus aureus growth arrest by induction of the endoribonuclease MazF toxin
Insights into the global effect on Staphylococcus aureus growth arrest by induction of the endoribonuclease MazF toxin Open
A crucial bacterial strategy to avoid killing by antibiotics is to enter a growth arrested state, yet the molecular mechanisms behind this process remain elusive. The conditional overexpression of mazF, the endoribonuclease toxin of the Ma…
View article: Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus
Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus Open
Magnesium is one of the most abundant metal ions in living cells. Very specific and devoted transporters have evolved for transporting Mg2+ ions across the membrane and maintain magnesium homeostasis. Using genetic screens, we were able to…
View article: Both exo- and endo-nucleolytic activities of RNase J1 from <i>Staphylococcus aureus</i> are manganese dependent and active on triphosphorylated 5′-ends
Both exo- and endo-nucleolytic activities of RNase J1 from <i>Staphylococcus aureus</i> are manganese dependent and active on triphosphorylated 5′-ends Open
RNA decay and RNA maturation are important steps in the regulation of bacterial gene expression. RNase J, which is present in about half of bacterial species, has been shown to possess both endo- and 5' to 3' exo-ribonuclease activities. T…
View article: Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria
Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria Open
Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, …
View article: Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria
Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria Open
Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, …
View article: An Essential Factor for High Mg2+ Tolerance of Staphylococcus aureus
An Essential Factor for High Mg2+ Tolerance of Staphylococcus aureus Open
Internal bacterial concentration of Mg2+, the most abundant divalent cation in living cells, is estimated to be in the single millimolar range. However, many bacteria will thrive in media with only micromolars of Mg2+, by using a range of …
View article: TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens
TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens Open
Mapping transcription start sites, and subsequent correlation with the genomic sequence, provides a multitude of important information about the regulation of gene expression, both at the transcriptional and translational level, by definin…
View article: Correction: Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation
Correction: Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation Open
[This corrects the article DOI: 10.1371/journal.pgen.1005577.].
View article: Additional file 5: Table S4. of TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens
Additional file 5: Table S4. of TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens Open
Predicted operon structure based on TSS-EMOTE experimental data and in silico transcription terminator finding. Note that this table includes two sheets for A. baumannii, corresponding to two published reference genomes (ATCC 17978, and AT…
View article: Additional file 1: Table S1. of TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens
Additional file 1: Table S1. of TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens Open
Re-detection of previously identified TSSs. (XLSX 13 kb)
View article: Additional file 3: Table S2. of TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens
Additional file 3: Table S2. of TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens Open
List of identified TSSs. Note that this table includes two sheets for A. baumannii, corresponding to two published reference genomes (ATCC 17978, and ATCC 17978-mff). (XLSX 3099 kb)
View article: Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation
Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation Open
Bacteria depend on efficient RNA turnover, both during homeostasis and when rapidly altering gene expression in response to changes. Nevertheless, remarkably few details are known about the rate-limiting steps in targeting and decay of RNA…
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen<i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen<i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…
View article: Bacterial versatility requires DEAD-box RNA helicases
Bacterial versatility requires DEAD-box RNA helicases Open
RNA helicases of the DEAD-box and DEAH-box families are important players in many processes involving RNA molecules. These proteins can modify RNA secondary structures or intermolecular RNA interactions and modulate RNA-protein complexes. …
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…
View article: The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i>
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA D…