Peter R. Rich
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View article: Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase
Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase Open
Cytochrome c oxidase is the terminal complex of the respiratory chains in the mitochondria of nearly all eu-karyotes. It catalyzes the reduction of molecular O-2 to water using electrons from the respiratory chain, delivered via cytochrome…
View article: Electron Transfer Coupled to Conformational Dynamics in Cell Respiration
Electron Transfer Coupled to Conformational Dynamics in Cell Respiration Open
Cellular respiration is a fundamental process required for energy production in many organisms. The terminal electron transfer complex in mitochondrial and many bacterial respiratory chains is cytochrome c oxidase (C c O). This converts th…
View article: Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria
Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria Open
Redox states of the mitochondrial coenzyme Q pool, which reacts with the electron transfer system, reflect the balance between (1) reducing capacities of electron flow from fuel substrates converging at the Q-junction, (2) oxidative capaci…
View article: Radical-Triggered Reaction Mechanism of the Green-to-Red Photoconversion of EosFP
Radical-Triggered Reaction Mechanism of the Green-to-Red Photoconversion of EosFP Open
Reaction intermediates in the green-to-red photoconversion of the photochromic fluorescent protein EosFP have been observed using high-intensity continuous blue illumination. An intermediate was identified through light-induced accumulatio…
View article: A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria
A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria Open
Significance We present a comprehensive investigation of mitochondrial DNA-encoded variants of cytochrome c oxidase (C c O) that harbor mutations within their core catalytic subunit I, designed to interrogate the presently disputed functio…
View article: The H channel is not a proton transfer path in yeast cytochrome c oxidase
The H channel is not a proton transfer path in yeast cytochrome c oxidase Open
Cytochrome c oxidases (CcOs) in the respiratory chains of mitochondria and bacteria are primary consumers of molecular oxygen, converting it to water with the concomitant pumping of protons across the membrane to establish a proton electro…
View article: Comparison of redox and ligand binding behaviour of yeast and bovine cytochrome c oxidases using FTIR spectroscopy
Comparison of redox and ligand binding behaviour of yeast and bovine cytochrome c oxidases using FTIR spectroscopy Open
Redox and CO photolysis FTIR spectra of yeast cytochrome c oxidase WT and mutants are compared to those from bovine and P. denitrificans CcOs in order to establish common functional features. All display changes that can be assigned to the…
View article: Insights into functions of the H channel of cytochrome <i>c</i> oxidase from atomistic molecular dynamics simulations
Insights into functions of the H channel of cytochrome <i>c</i> oxidase from atomistic molecular dynamics simulations Open
Significance Cytochrome oxidase is a widespread respiratory enzyme that conserves energy released when oxygen is reduced by pumping protons across the membrane in which it is located. Here, we use atomistic simulations of the whole bovine …
View article: Infrared vibrational spectroscopy: a rapid and novel diagnostic and monitoring tool for cystinuria
Infrared vibrational spectroscopy: a rapid and novel diagnostic and monitoring tool for cystinuria Open
Cystinuria is the commonest inherited cause of nephrolithiasis (~1% in adults; ~6% in children) and is the result of impaired cystine reabsorption in the renal proximal tubule. Cystine is poorly soluble in urine with a solubility of ~1 mM …
View article: Effects of the Hydration State on the Mid-Infrared Spectra of Urea and Creatinine in Relation to Urine Analyses
Effects of the Hydration State on the Mid-Infrared Spectra of Urea and Creatinine in Relation to Urine Analyses Open
When analyzing solutes by Fourier transform infrared (FT-IR) spectroscopy in attenuated total reflection (ATR) mode, drying of samples onto the ATR crystal surface can greatly increase solute band intensities and, therefore, aid detection …