Peter Rozik
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View article: Mistranslating the genetic code with leucine in yeast and mammalian cells
Mistranslating the genetic code with leucine in yeast and mammalian cells Open
Translation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do not recognize the anticodon bases. Single nu…
View article: A novel fluorescent reporter sensitive to serine mis-incorporation
A novel fluorescent reporter sensitive to serine mis-incorporation Open
High-fidelity translation was considered a requirement for living cells. The frozen accident theory suggested that any deviation from the standard genetic code should result in the production of so much mis-made and non-functional proteins…
View article: A novel fluorescent reporter sensitive to serine mis-incorporation
A novel fluorescent reporter sensitive to serine mis-incorporation Open
High-fidelity translation was considered a requirement for living cells. The frozen accident theory suggested that any deviation from the standard genetic code should result in the production of so much mis-made and non-functional proteins…