Peter S. Pang
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View article: Clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute heart failure
Clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute heart failure Open
Aims Residual congestion (RC) is common at discharge after acute decompensated heart failure (ADHF) and is associated with early mortality and rehospitalization. The prognostic value of distinct RC phenotypes (i.e. intravascular and tissue…
View article: Impact of Mild and Moderate Aortic Stenosis in Acute Heart Failure: Insights From RELAX-AHF-2
Impact of Mild and Moderate Aortic Stenosis in Acute Heart Failure: Insights From RELAX-AHF-2 Open
The presence of mild or moderate aortic stenosis reflects an increased risk profile in patients with acute heart failure, but it is not an independent predictor of poor clinical outcomes.
View article: Blood Pressure Effects and Risk of Hypotension due to Intravenous Furosemide in Acute Decompensated Heart Failure
Blood Pressure Effects and Risk of Hypotension due to Intravenous Furosemide in Acute Decompensated Heart Failure Open
Objective We quantified the magnitude of systolic blood pressure (SBP) adverse effects associated with intravenous furosemide (IVFu), compared to other factors, during treatment for acute decompensated heart failure (ADHF). Methods Continu…
View article: Letter of Concern from the Association of Academic Chairs of Emergency Medicine Regarding ACGME Proposed Changes.
Letter of Concern from the Association of Academic Chairs of Emergency Medicine Regarding ACGME Proposed Changes. Open
This letter, signed by over 50 academic chairs of emergency medicine, urges the ACGME to reconsider a proposed mandate requiring all emergency medicine residency programs to adopt a four-year training model. The authors argue that current …
View article: Emergency Physician Perspectives on the Use of Patient Experience Surveys
Emergency Physician Perspectives on the Use of Patient Experience Surveys Open
Introduction Although emergency medicine specialty societies have published policy statements on the use of patient experience data, we know little about how these data are currently used within physician groups. We also have little inform…
View article: Changes in Liver Function Tests, Congestion, and Prognosis After Acute Heart Failure
Changes in Liver Function Tests, Congestion, and Prognosis After Acute Heart Failure Open
View article: Socio‐economic status and the effect of guideline‐directed medical therapy in the STRONG‐HF study
Socio‐economic status and the effect of guideline‐directed medical therapy in the STRONG‐HF study Open
Aims Acute heart failure (AHF) impacts millions globally, with outcomes varying based on socio‐economic status (SES). Methods SES measured by annual household income, years of education and medical insurance coverage. Each patient's income…
View article: End‐organ protective effect of serelaxin in patients hospitalized for heart failure: Results of the biomarker substudy of Relaxin in Acute Heart Failure‐2 (<scp>RELAX</scp>‐<scp>AHF</scp>‐2)
End‐organ protective effect of serelaxin in patients hospitalized for heart failure: Results of the biomarker substudy of Relaxin in Acute Heart Failure‐2 (<span>RELAX</span>‐<span>AHF</span>‐2) Open
Aims Serelaxin is recombinant human relaxin‐2, a hormone responsible for haemodynamic adaptations and organ protection in pregnancy. In the RELAX‐AHF trial, serelaxin demonstrated reductions in cardiac, renal and hepatic damage. In RELAX‐A…
View article: Decongestion and Outcomes in Patients Hospitalized for Acute Heart Failure
Decongestion and Outcomes in Patients Hospitalized for Acute Heart Failure Open
View article: Emergency Department Food Insecurity Screening, Food Voucher Distribution and Utilization: A Prospective Cohort Study
Emergency Department Food Insecurity Screening, Food Voucher Distribution and Utilization: A Prospective Cohort Study Open
Objective: Food insecurity is a prevalent social risk among emergency department (ED) patients. Patients who may benefit from food insecurity resources may be identified via ED-based screening; however, many patients experience difficulty acc…
View article: Insights on prevalence and incidence of anemia and rapid up-titration of oral heart failure treatment from the STRONG-HF study
Insights on prevalence and incidence of anemia and rapid up-titration of oral heart failure treatment from the STRONG-HF study Open
View article: Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the <scp>RELAX</scp>‐<scp>AHF</scp>‐2 trial
Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the <span>RELAX</span>‐<span>AHF</span>‐2 trial Open
Aims Acute heart failure (AHF) is a major cause of hospitalizations and death in the elderly. However, elderly patients are often underrepresented in randomized clinical trials. We analysed the impact of age on clinical outcomes and respon…
View article: Rapid Uptitration of Guideline-Directed Medical Therapies in Acute Heart Failure With and Without Atrial Fibrillation
Rapid Uptitration of Guideline-Directed Medical Therapies in Acute Heart Failure With and Without Atrial Fibrillation Open
View article: Bereavement scheduling policy for emergency medicine residents: A descriptive pilot study
Bereavement scheduling policy for emergency medicine residents: A descriptive pilot study Open
Background The Accreditation Council for Graduate Medical Education has tasked residency programs to prioritize resident wellness, reduce trainee stress, and prevent burnout. Grief and bereavement can significantly impact residents' wellne…
View article: Effects of Rapid Uptitration of Neurohormonal Blockade on Effective, Sustainable Decongestion and Outcomes in STRONG-HF
Effects of Rapid Uptitration of Neurohormonal Blockade on Effective, Sustainable Decongestion and Outcomes in STRONG-HF Open
View article: Biologically active adrenomedullin as a marker for residual congestion and early rehospitalization in patients hospitalized for acute heart failure: Data from <scp>STRONG</scp>‐<scp>HF</scp>
Biologically active adrenomedullin as a marker for residual congestion and early rehospitalization in patients hospitalized for acute heart failure: Data from <span>STRONG</span>‐<span>HF</span> Open
Aims Biologically active adrenomedullin (bio‐ADM) is a promising marker of residual congestion. The STRONG‐HF trial showed that high‐intensity care (HIC) of guideline‐directed medical therapy (GDMT) improved congestion and clinical outcome…
View article: Characteristics, treatment, and outcomes of early vs. late enrollees of the STRONG-HF trial
Characteristics, treatment, and outcomes of early vs. late enrollees of the STRONG-HF trial Open
ClinicalTrials.gov Identifier: NCT03412201.
View article: Titration of Medications After Acute Heart Failure Is Safe, Tolerated, and Effective Regardless of Risk
Titration of Medications After Acute Heart Failure Is Safe, Tolerated, and Effective Regardless of Risk Open
View article: Impact of Rapid Up-Titration of Guideline-Directed Medical Therapies on Quality of Life: Insights From the STRONG-HF Trial
Impact of Rapid Up-Titration of Guideline-Directed Medical Therapies on Quality of Life: Insights From the STRONG-HF Trial Open
BACKGROUND: This analysis provides details on baseline and changes in quality of life (QoL) and its components as measured by EQ-5D-5L questionnaire, as well as association with objective outcomes, applying high-intensity heart failure (HF…
View article: Blood pressure and intensive treatment up‐titration after acute heart failure hospitalization: Insights from the <scp>STRONG‐HF</scp> trial
Blood pressure and intensive treatment up‐titration after acute heart failure hospitalization: Insights from the <span>STRONG‐HF</span> trial Open
Aims A high‐intensity care (HIC) strategy with rapid guideline‐directed medical therapy (GDMT) up‐titration and close follow‐up visits improved outcomes, compared to usual care (UC), in patients recently hospitalized for acute heart failur…
View article: Short-Stay Units vs Routine Admission From the Emergency Department in Patients With Acute Heart Failure
Short-Stay Units vs Routine Admission From the Emergency Department in Patients With Acute Heart Failure Open
Importance More than 80% of patients who present to the emergency department (ED) with acute heart failure (AHF) are hospitalized. With more than 1 million annual hospitalizations for AHF in the US, safe and effective alternatives are need…
View article: The Association Between Patient Demographics and ED Experience Scores is Related to Differing Perceptions of Care and Compassion: A Cross Sectional Study Using Natural Language Processing of Patient Comments
The Association Between Patient Demographics and ED Experience Scores is Related to Differing Perceptions of Care and Compassion: A Cross Sectional Study Using Natural Language Processing of Patient Comments Open
View article: Optimization of Evidence-Based Heart Failure Medications After an Acute Heart Failure Admission
Optimization of Evidence-Based Heart Failure Medications After an Acute Heart Failure Admission Open
Importance The Safety, Tolerability, and Efficacy of Rapid Optimization, Helped by N-Terminal Pro–Brain Natriuretic Peptide Testing of Heart Failure Therapies (STRONG-HF) trial strived for rapid uptitration aiming to reach 100% optimal dos…
View article: Safety Indicators in Patients Receiving High-intensity Care After Hospital Admission for Acute Heart Failure: The STRONG-HF Trial
Safety Indicators in Patients Receiving High-intensity Care After Hospital Admission for Acute Heart Failure: The STRONG-HF Trial Open
Among patients with acute HF enrolled in STRONG-HF in the HIC arm, the occurrence of any safety indicator was associated with the administration of slightly lower GDMT doses and less improvement in quality of life, but with no significant …
View article: Non‐cardiac comorbidities and intensive up‐titration of oral treatment in patients recently hospitalized for heart failure: Insights from the <scp>STRONG‐HF</scp> trial
Non‐cardiac comorbidities and intensive up‐titration of oral treatment in patients recently hospitalized for heart failure: Insights from the <span>STRONG‐HF</span> trial Open
Aims To assess the potential interaction between non‐cardiac comorbidities (NCCs) and the efficacy and safety of high‐intensity care (HIC) versus usual care (UC) in the STRONG‐HF trial, including stable patients with improved but still ele…
View article: The significance of historical troponin elevation in acute heart failure: Not as reassuring as previously assumed
The significance of historical troponin elevation in acute heart failure: Not as reassuring as previously assumed Open
Background Historical cardiac troponin (cTn) elevation is commonly interpreted as lessening the significance of current cTn elevations at presentation for acute heart failure (AHF). Evidence for this practice is lacking. Our objective was …
View article: The prognostic value of improving congestion on lung ultrasound during treatment for acute heart failure differs based on patient characteristics at admission
The prognostic value of improving congestion on lung ultrasound during treatment for acute heart failure differs based on patient characteristics at admission Open
View article: Mineralocorticoid receptor antagonist initiation during admission is associated with improved outcomes irrespective of ejection fraction in patients with acute heart failure
Mineralocorticoid receptor antagonist initiation during admission is associated with improved outcomes irrespective of ejection fraction in patients with acute heart failure Open
Aims Heart failure (HF) guidelines recommend initiation and optimization of guideline‐directed medical therapy, including mineralocorticoid receptor antagonists (MRAs), before hospital discharge. However, scientific evidence for this recom…
View article: Uptitrating Treatment After Heart Failure Hospitalization Across the Spectrum of Left Ventricular Ejection Fraction
Uptitrating Treatment After Heart Failure Hospitalization Across the Spectrum of Left Ventricular Ejection Fraction Open
View article: Safety, tolerability and efficacy of up‐titration of guideline‐directed medical therapies for acute heart failure in elderly patients: A sub‐analysis of the <scp>STRONG‐HF</scp> randomized clinical trial
Safety, tolerability and efficacy of up‐titration of guideline‐directed medical therapies for acute heart failure in elderly patients: A sub‐analysis of the <span>STRONG‐HF</span> randomized clinical trial Open
Aims STRONG‐HF examined a high‐intensity care (HIC) strategy of rapid up‐titration of guideline‐directed medical therapy (GDMT) and close follow‐up after acute heart failure (AHF) admission. We assess the role of age on efficacy and safety…