Explanipedia

Characterization of Patients with Difficult-to-Treat Acute Pain Following Total Knee Arthroplasty Using Multi-Modal Analgesia Open

Syed Azim, Rebecca Sangster, Christine A. Curcio, Dominick Coleman, Usman Shah , et al. · 2013

Objective: To determine the efficacy of post-operative pain control over the first 24 hours in patients undergoing unilateral total knee arthroplasty (TKA) using a multi-modal analgesia protocol including femoral nerve catheters (FNC). Mat…

Multimodal therapies for postoperative nausea and vomiting, and pain Open

Arvind Chandrakantan, Peter S. A. Glass · 2011

Evaluation of prostaglandin D2 as a CSF leak marker: implications in safe epidural anesthesia Open

Pentyala, Sirish Kondabolu, Rishimani Adsumelli, J Schabel, Peter S. A. Glass · 2011

Prostaglandin D2 was reliably identified in CSF by enzyme-linked immunosorbent assay when diluted with local anesthetic, saline, and serum, and can be used as a marker to identify the presence of CSF in epidural aspirates.

The metabolomic profile during isoflurane anesthesia differs from propofol anesthesia in the live rodent brain Open

Rany Makaryus, Hedok Lee, Mei Yu, Shaonan Zhang, Shane Smith , et al. · 2011

Development of noninvasive techniques to discover new biomarkers in the live brain is important to further understand the underlying metabolic pathways of significance for processes such as anesthesia-induced apoptosis and cognitive dysfun…

Automated control of anesthesia ten years later: futuristic novelty or present day reality Open

Peter S. A. Glass · 2010

Contents Open

Lee A. Fleisher, Peter S. A. Glass, Deborah C. Richman · 2010

Age-Associated Differences in Activation of Akt/GSK-3 Signaling Pathways and Inhibition of Mitochondrial Permeability Transition Pore Opening in the Rat Heart Open

Jieping Zhu, Mario J. Rebecchi, Ming Jen Tan, Peter S. A. Glass, Peter R. Brink , et al. · 2010

Pretreatment with isoflurane decreased myocardial infarction size in young rats (3-5 months) but not in old rats (20-24 months). To understand the mechanisms underlying the failure to protect the old myocardium, differences in phosphorylat…

Half-time or Half-life Open

Peter S. A. Glass, David S. Warner · 2010

Elimination half-life is the pharmacokinetic parameter used most commonly to describe duration of pharmacologic action, including that expected of intravenous anesthetic drugs administered by continuous infusion.Little consideration has be…

Age-associated Changes in Cardiac Gene Expression after Preconditioning Open

Lixin Liu, Jiang Zhu, Peter S. A. Glass, Peter R. Brink, Ira J. Rampil , et al. · 2009

Background Cardiac protection afforded by ischemic preconditioning (IPC) and anesthetic preconditioning (APC) are significantly reduced in the senescent myocardium. The authors hypothesized that age would differentially modulate gene expre…

The Effect of Intravenous Lidocaine on Brain Activation During Non-Noxious and Acute Noxious Stimulation of the Forepaw: A Functional Magnetic Resonance Imaging Study in the Rat Open

Zhongchi Luo, Yu Mei, Shane Smith, Mary F. Kritzer, Congwu Du , et al. · 2008

The analgesic action of systemic lidocaine in acute pain is not reflected in a straightforward interruption of pain-induced fMRI brain activation as has been observed with opioids. The enhancement of cortical fMRI responses to acute pain b…

It's the Colloid, Not the Esophageal Doppler Monitor Open

Tong J. Gan, Kerri M. Robertson, Eugene Moretti, Peter S. A. Glass · 2003

In Reply:—Thank you for allowing us the opportunity to respond to the letter by Horowitz and Kumar. In our study, 1we investigated whether goal-directed intraoperative plasma volume expansion guided by the esophageal Doppler monitor would …

Goal-directed Intraoperative Fluid Administration Reduces Length of Hospital Stay after Major Surgery Open

Tong J. Gan, Andrew J Soppitt, Mohamed Maroof, Habib El-Moalem, Kerri M. Robertson , et al. · 2002

Background Intraoperative hypovolemia is common and is a potential cause of organ dysfunction, increased postoperative morbidity, length of hospital stay, and death. The objective of this prospective, randomized study was to assess the eff…

Automated Anesthesia Open

Peter S. A. Glass, Ira J. Rampil · 2001

Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, New York.IN this issue of Anesthesiology, Struys et al. 1provide a challenge to us as anesthesiologists. Can automated closed-loop anesthesia improve p…

Assessment of Depth of Anesthesia and Postoperative Respiratory Recovery after Remifentanil-versus Alfentanil-based Total Intravenous Anesthesia in Patients Undergoing Ear–Nose–Throat Surgery Open

Rainer Wuesten, Hugo Van Aken, Peter S. A. Glass, Hartmut Buerkle · 2001

Background The authors investigated whether total intravenous anesthesia (TIVA) with precalculated equipotent infusion schemes for remifentanil and alfentanil would ensure appropriate analgesia and that remifentanil would result in better …

Changes in the Auditory Evoked Potentials and the Bispectral Index following Propofol or Propofol and Alfentanil Open

Irène A. Iselin-Chaves, H El Moalem, Tong J. Gan, Brian Ginsberg, Peter S. A. Glass · 2000

Background Midlatency auditory evoked potentials (MLAEP) show graded changes with increasing doses of hypnotics but little change with opioids. The effect of their combination on the MLAEP was evaluated. Also, the bispectral index (BIS) wa…

Cost-effectiveness of Prophylactic Antiemetic Therapy with Ondansetron, Droperidol, or Placebo Open

Robert P. Hill, David A. Lubarsky, Yi‐Ju Li, Jennifer T. Fortney, Mary R. Creed , et al. · 2000

Background In an era of growing economic constraints on healthcare delivery, anesthesiologists are increasingly expected to understand cost analysis and evaluate clinical practices. Postoperative nausea and vomiting (PONV) are distressing …

Dosing study of remifentanil and propofol for tracheal intubation without the use of muscle relaxants Open

R. Alexander, Adeyemi J. Olufolabi, John V. Booth, Habib El-Moalem, Peter S. A. Glass · 1999

Sixty ASA I and II patients, premedicated with midazolam, were administered propofol 2 mg.kg −1 and remifentanil 3 μg.kg −1 (group R3), remifentanil 4 μg.kg −1 (group R4) and remifentanil 5 μg.kg −1 (group R5). Laryngoscopy and intubation …

Determination of the Potency of Remifentanil Compared with Alfentanil Using Ventilatory Depression as the Measure of Opioid Effect Open

Peter S. A. Glass, Irène A. Iselin-Chaves, David K. Goodman, Elizabeth R. DeLong, David Hermann · 1999

Background Remifentanil is a new opioid with properties similar to other mu-specific agonists. To establish its pharmacologic profile relative to other known opioids, it is important to determine its potency. This study investigated the re…

Women Emerge from General Anesthesia with Propofol/Alfentanil/Nitrous Oxide Faster than Men Open

Tong J. Gan, Peter S. A. Glass, Jeff C Sigl, Peter S. Sebel, F. C. Payne , et al. · 1999

Background Recovery from general anesthesia is governed by pharmacodynamic and pharmacokinetic factors. Gender has not previously been recognized as a factor influencing the time to emergence from general anesthesia. Methods This multicent…

Targeting Effect Compartment or Central Compartment Concentration of Propofol Open

Howard G. Wakeling, John B. Zimmerman, Scott Howell, Peter S. A. Glass · 1999

Background An effect compartment has been postulated, and the ke0 has been quantified for several intravenous anesthetic drugs using electroencephalography (EEG) as the measure of effect. The authors wanted to validate that loss of respons…

Intravenous Infusion Techniques: how to do it and why we should do it Open

Peter S. A. Glass · 1998

Anesthetic Drug Interactions Open

Peter S. A. Glass · 1998

Opioid-sparing Effects of a Low-dose Infusion of Naloxone in Patient-administered Morphine Sulfate Open

Tong J. Gan, Brian Ginsberg, Peter S. A. Glass, Jennifer T. Fortney, Rajiv Jhaveri , et al. · 1997

Background A naloxone infusion is effective in reducing epidural and intrathecal opioid-related side effects. The use of naloxone infusion concomitant with intravenous morphine patient-controlled analgesia (PCA) has not been evaluated, pro…

Bispectral Index Monitoring Allows Faster Emergence and Improved Recovery from Propofol, Alfentanil, and Nitrous Oxide Anesthesia Open

Tong J. Gan, Peter S. A. Glass, Alastair Windsor, F. C. Payne, Carl E. Rosow , et al. · 1997

Background The bispectral index (BIS), a parameter derived from the electroencephalograph (EEG), has been shown to correlate with increasing sedation and loss of consciousness. This study determined whether addition of BIS monitoring to st…

Determination of Plasma Concentrations of Propofol Associated with 50% Reduction in Postoperative Nausea Open

T.J. Gan, Peter S. A. Glass, Scott Howell, Andrew T. Canada, Alan Grant , et al. · 1997

Background Subhypnotic doses of propofol possess direct antiemetic properties. The authors sought to determine the plasma concentration of propofol needed to effectively manage postoperative nausea and vomiting. Methods Patients aged 18-70…

Pharmacokinetics Anesthesiologists, and Pharmacodynamics of Remifentanil in Persons with Renal Failure Compared with Healthy Volunteers Open

Frank Hoke, D. Shlugman, Mark Dershwitz, Piotr Michałowski, Sherry Malthouse-Dufore , et al. · 1997

Background Remifentanil is an opioid analgesic for use in anesthesia. An ester linkage renders it susceptible to rapid metabolism by blood and tissue esterases. Thus it was hypothesized that remifentanil elimination would be independent of…

The Successful Implementation of Pharmaceutical Practice Guidelines Open

David A. Lubarsky, Peter S. A. Glass, Brian Ginsberg, Guy L. de Dear, Mark E. Dentz , et al. · 1997

Background Although approximately 2,000 medical practice guidelines have been proposed, few have been successfully implemented and sustained. We hypothesized that we could develop and institute practice guidelines to promote more appropria…

Bispectral Analysis Measures Sedation and Memory Effects of Propofol, Midazolam, Isoflurane, and Alfentanil in Healthy Volunteers Open

Peter S. A. Glass, M. Bloom, Lee A. Kearse, Carl E. Rosow, Peter S. Sebel , et al. · 1997

Background The bispectral index (BIS), a value derived from the electroencephalograph (EEG), has been proposed as a measure of anesthetic effect. To establish its utility for this purpose, it is important to determine the relation among BI…

Pharmacokinetic Model-driven Infusion of Fentanyl in Children Open

Brian Ginsberg, Scott Howell, Peter S. A. Glass, Judith O. Margolis, Allison Kinder Ross , et al. · 1996

Background This study determined the accuracy of previously defined adult fentanyl pharmacokinetics in children having surgery; from this population, the pharmacokinetics of fentanyl were characterized in children when administered via a c…

Double-blind, Randomized Comparison of Ondansetron and Intraoperative Propofol to Prevent Postoperative Nausea And Vomiting Open

Tong J. Gan, Brian Ginsberg, Alan Grant, Peter S. A. Glass · 1996

Background Breast surgery is associated with a high incidence of postoperative nausea and vomiting. Propofol and prophylactic administration of ondansetron are associated with a lower incidence of postoperative nausea and vomiting. To date…

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