Peter Sahlström
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View article: POS0004 PRO-INFLAMMATORY ANTI-MODIFIED PROTEIN AUTOANTIBODIES DERIVED FROM BONE MARROW, SYNOVIAL, AND LUNG B CELLS PREFERENTIALLY TARGET MALONDIALDEHYDE-ACETALDEHYDE CROSS-LINKED MOLECULAR STRUCTURES
POS0004 PRO-INFLAMMATORY ANTI-MODIFIED PROTEIN AUTOANTIBODIES DERIVED FROM BONE MARROW, SYNOVIAL, AND LUNG B CELLS PREFERENTIALLY TARGET MALONDIALDEHYDE-ACETALDEHYDE CROSS-LINKED MOLECULAR STRUCTURES Open
Background Autoantibodies to malondialdehyde (MDA) proteins constitute a subset of anti-modified protein autoantibodies (AMPA) in rheumatoid arthritis (RA), which is not directly overlapping with citrulline reactivity. We have previously s…
View article: Molecular signature of methotrexate response among rheumatoid arthritis patients
Molecular signature of methotrexate response among rheumatoid arthritis patients Open
Background Methotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but failure of satisfying treatment response occurs in a significant proportion of patients. Here we present a longitudinal multi-omics study aimed at…
View article: Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis
Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis Open
Rheumatoid Arthritis (RA) is a prevalent autoimmune disease characterized by inflammation of peripheral joints. Patients can be subdivided by the presence or absence of Rheumatoid Factor and anti-citrullinated protein antibodies (ACPA) in …
View article: Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis
Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis Open
Objectives Advances in immunotherapy by blocking TNF have remarkably improved treatment outcomes for Rheumatoid arthritis (RA) patients. Although treatment specifically targets TNF, the downstream mechanisms of immune suppression are not c…
View article: Early Prediction of Clinical Response to Anti-TNF Treatment using Multi-omics and Machine Learning in Rheumatoid Arthritis
Early Prediction of Clinical Response to Anti-TNF Treatment using Multi-omics and Machine Learning in Rheumatoid Arthritis Open
ObjectivesAdvances in immunotherapy by blocking TNF have remarkably improved treatment outcomes for rheumatoid arthritis patients. Although treatment specifically targets TNF, the downstream mechanisms of immune suppression are not complet…
View article: Molecular Biomarkers of Anti-TNF Response in Patients with Rheumatoid Arthritis
Molecular Biomarkers of Anti-TNF Response in Patients with Rheumatoid Arthritis Open
Background Advances in immunotherapy by blocking TNF have remarkably improved treatment outcomes for rheumatoid arthritis (RA) patients. Although treatment specifically targets TNF-α, the downstream mechanisms of immune suppression are not…
View article: Different Hierarchies of Anti–Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis
Different Hierarchies of Anti–Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis Open
Objective Anti–citrullinated protein antibodies (ACPAs) are a hallmark of seropositive rheumatoid arthritis (RA). Yet, the precise disease‐relevant autoantigens that are targeted by ACPAs remains a matter of debate. This study utilized pat…
View article: Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interacti…
View article: A Refined Protocol for Identifying Citrulline-specific Monoclonal Antibodies from Single Human B Cells from Rheumatoid Arthritis Patient Material
A Refined Protocol for Identifying Citrulline-specific Monoclonal Antibodies from Single Human B Cells from Rheumatoid Arthritis Patient Material Open
We describe here a detailed, refined protocol for the generation of citrulline-specific monoclonal antibodies from single human B cells from rheumatoid arthritis (RA) patients. This protocol provides a detailed guide of the procedure start…
View article: Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis Open
Objective Antibodies against posttranslationally modified proteins are a hallmark of rheumatoid arthritis ( RA ), but the emergence and pathogenicity of these autoantibodies are still incompletely understood. The aim of this study was to a…