Peter Sander
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View article: Simulated use of the Water Circuit Disinfection Device on a Mycobacterium chimaera-contaminated LivaNova 3T Heater Cooler Device – results of mycobacterial and bacterial surveillance
Simulated use of the Water Circuit Disinfection Device on a Mycobacterium chimaera-contaminated LivaNova 3T Heater Cooler Device – results of mycobacterial and bacterial surveillance Open
The installation of WCDD on a contaminated LivaNova 3T HCD was not associated with significant changes in mycobacterial contamination.
View article: c-Myc Inhibits Macrophage Antimycobacterial Response in <i>Mycobacterium tuberculosis</i> Infection
c-Myc Inhibits Macrophage Antimycobacterial Response in <i>Mycobacterium tuberculosis</i> Infection Open
Background Mycobacterium tuberculosis (MTB) remains a major cause of global mortality, yet natural immunity prevents disease in more than 90% of exposed individuals. Interferon gamma (IFN-γ) is a critical regulator of innate immunity and e…
AveloMask, a novel breath aerosol collection kit for airborne <i>Mycobacterium tuberculosis</i> : a proof-of-principle assessment Open
Tuberculosis (TB) remains the world’s deadliest infectious disease, with many active cases missed due to challenges in sputum collection. Exhaled breath aerosols (XBA), a major route of Mycobacterium tuberculosis (MTB) transmission, offer …
Selective inhibition of <i>Mycobacterium tuberculosis</i> GpsI unveils a novel strategy to target the RNA metabolism Open
Polyribonucleotide nucleotidyl-transferases (PNPases) play a critical role in the degradation of mRNA. The mycobacterial PNPase, guanosine penta-phosphate synthase I (GpsI), is an essential enzyme in Mycobacterium tuberculosis (Mtb), colla…
Dichalcogenide Fidaxomicin Derivatives to Probe Thiol-Mediated Uptake into Bacteria Open
The natural product fidaxomicin (Fdx) is a narrow-spectrum antibiotic clinically prescribed for the treatment of Clostrodioides difficile infections. However, limited cellular uptake reduces its therapeutic potential, particularly against …
AveloMask, a novel breath aerosol collection kit for airborne<i>Mycobacterium tuberculosis</i>: a proof-of-principle assessment Open
Background Tuberculosis (TB) remains the world’s deadliest infectious disease, with sputum-based diagnostics failing to detect many active cases, often due to difficulty in specimen collection. Breath aerosols, a major route of Mycobacteri…
View article: c-Myc inhibits macrophage antimycobacterial response in <i>Mycobacterium tuberculosis</i> infection
c-Myc inhibits macrophage antimycobacterial response in <i>Mycobacterium tuberculosis</i> infection Open
Mycobacterium tuberculosis (MTB) is a major global cause of mortality worldwide, responsible for over a million deaths annually. Despite this burden, natural immunity prevents disease in more than 90% of exposed individuals. Previous studi…
Switching Residues: A Platform for the Synthesis of Fidaxomicin Antibiotics Open
Peripheral modification is often the main approach to optimize natural products for improved biological activity or desired physicochemical properties. This procedure inevitably increases molecular weight, often accompanied by undesired in…
Durlobactam to boost the clinical utility of standard of care β-lactams against <i>Mycobacterium abscessus</i> lung disease Open
β-Lactams present several desirable pharmacodynamic features leading to the rapid eradication of many bacterial pathogens. Imipenem (IPM) and cefoxitin (FOX) are injectable β-lactams recommended during the intensive treatment phase of pulm…
View article: Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in<i>Mycobacterium</i>abscessus
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in<i>Mycobacterium</i>abscessus Open
Mycobacterium abscessus ( Mab ), a nontuberculous mycobacterial (NTM) species, is an emerging pathogen with high intrinsic drug resistance. Current standard-of-care therapy results in poor outcomes, demonstrating the urgent need to develop…
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species (ChemBioChem 24/2023)** Open
The narrow-spectrum antibiotic fidaxomicin is active against a small number of Gram-positive bacteria. New antibiotics were synthesized through modification the two phenolic hydroxy groups of fidaxomicin. The authors studied how switching …
Dataset for "Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species" Open
ZIP File: Characterisation data (such as e.g. NMR, IR, MS spectra) NMR raw data, .mnova files ChemDraw drawings (.cdx files) PDF file: Supporting information for Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic …
Dataset for "Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species" Open
ZIP File: Characterisation data (such as e.g. NMR, IR, MS spectra) NMR raw data, .mnova files ChemDraw drawings (.cdx files) PDF file: Supporting information for Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic …
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species** Open
Fidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides difficile and other Gram‐positive bacteria such as Mycobacterium tuberculosis . Only a few Fdx derivatives have been synthesized and examined for…
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species Open
Fidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides difficile and other Gram-positive bacteria such as Mycobacterium tuberculosis. Only few Fdx derivatives have been synthesized and examined for th…
Development of a Project Objective and Requirement System (PORS) for major infrastructure projects to align the interests of all the stakeholders Open
Major infrastructure projects often exceed estimated costs and schedule. Therefore, they do not achieve the desired quality. The difference in objective interests of the project participants is a major problem. Based on the difficult contr…
The aminoglycoside-modifying enzyme Eis2 represents a new potential<i>in vivo</i>target for reducing antimicrobial drug resistance in<i>Mycobacterium abscessus</i>complex Open
This study identified innovative therapeutic targets to reinforce existing current antibiotic treatments against M. abscessus complex, exploiting a murine preclinical model of respiratory infection and 727 publicly available genomes from c…
<i>In Vitro</i> Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus Open
Bedaquiline and clofazimine are increasingly used to treat infections with Mycobacterium abscessus . We determined distributions of MICs by broth microdilution for bedaquiline and clofazimine for 61 M. abscessus clinical isolates using dif…
Photochemically-Mediated Inflammation and Cross-Presentation of Mycobacterium bovis BCG Proteins Stimulates Strong CD4 and CD8 T-Cell Responses in Mice Open
Conventional vaccines are very efficient in the prevention of bacterial infections caused by extracellular pathogens due to effective stimulation of pathogen-specific antibodies. In contrast, considering that intracellular surveillance by …
Apramycin Overcomes the Inherent Lack of Antimicrobial Bactericidal Activity in Mycobacterium abscessus Open
Antibiotic therapy of infections caused by the emerging pathogen Mycobacterium abscessus is challenging due to the organism’s inherent resistance to clinically available antimicrobials. The low bactericidal potency of currently available t…
Mycobacterium tuberculosis Phosphoribosyltransferase Promotes Bacterial Survival in Macrophages by Inducing Histone Hypermethylation in Autophagy-Related Genes Open
Mycobacterium tuberculosis (Mtb) inhibits autophagy to promote its survival in host cells. However, the molecular mechanisms by which Mtb inhibits autophagy are poorly understood. Here, we report a previously unknown mechanism in which Mtb…
Drug Susceptibility Distributions of Mycobacterium chimaera and Other Nontuberculous Mycobacteria Open
Recent outbreaks of cardiac surgery-associated Mycobacterium chimaera infections have highlighted the importance of species differentiation within the Mycobacterium avium complex and pointed to a lack of antibiotic susceptibility data for …
Rifabutin Is Inactivated by Mycobacterium abscessus Arr Open
Mycobacterium abscessus exhibits arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactiv…
Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation Open
The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good to excellent activity against Gram-positive bacteria and was approved for the treatment of Clostridium difficile infections (CDI). Among the…